PPE57
rv3425
PPE family protein PPE57
M. tuberculosis · H37Rv
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H37Rv Coordinates: 3842419 – 3842949
Vulnerability Index (VI):
M. smegmatis homologs MSMEG0619
M. abscessus homologs
 +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon TSS Legend ? Ju, 2024 (4) Cortes, 2013 (5) Shell, 2015 (3) (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 (4) PMID: 38418874 (5) PMID: 24268774 Rv3421c Rv3422c alr Rv3424c PPE57 PPE58 Rv3427c Rv3428c
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>rv3425_PPE57_dna
CCGGTGGTCAACGCTATTTGAGCCCCCCGCTTCCGACCCGGTGTCGAATAGGGATGAGGCCGCTCCTCCGCCAGCACATGAGGCAGTATCACCAGATCAGCTTTCCGGCCATAGAGCATCGTCACCGGGTTAGGCATGGTTTAGGCAGCGCTTAGCTGAGAACGCCGAGGCGTGTCGGCTCGCCGAGGCCCAAAACAGCACAACCTTGCACTGATCTAGCTGAAGACCAAACCGGCACAGCAGACATTGCCATACGCGACAACAGCCGTCATCAACCGAAAGGAGCAAAGAACAAACAGATGCATCCAATGATACCAGCGGAGTATATCTCCAACATAATATATGAAGGCCCGGGCGCTGACTCATTGTTTTTCGCCTCCGGGCAATTGCGAGAATTGGCTTACTCAGTTGAAACGACGGCTGAGTCGCTCGAGGACGAGCTCGACGAGCTGGATGAGAACTGGAAAGGTAGTTCGTCGGACTTGTTGGCCGACGCGGTTGAGCGGTATCTCCAATGGCTGTCTAAACACTCCAGTCAGCTTAAGCATGCCGCCTGGGTGATCAACGGCCTCGCGAACGCCTATAACGACACACGTCGGAAGGTGGTACCCCCGGAGGAGATCGCCGCCAACCGCGAGGAGAGGCGCAGGCTGATCGCGAGCAACGTGGCCGGGGTAAACACTCCAGCAATCGCAGACCTCGATGCACAATACGACCAGTACCGGGCCCGCAATGTCGCTGTAATGAACGCCTATGTAAGTTGGACCCGATCTGCGCTATCGGATCTGCCCCGGTGGCGGGAACCGCCGCAGATCTACAGGGGCGGGTAG

Protein Sequence 

>Rv3425_PPE57_protein
MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLEDELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVPPEEIAANREERRRLIASNVAGVNTPAIADLDAQYDQYRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]

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