1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	D	C	D	S	V	T	N	S	P	L	A	T	A	T	A	T	L	H	T	N	R	G	D	I	K	I	A	L	F	G	N	H	A	P	K	T	V	A	N	F	V	G	L	A	Q	G	T	K	D	Y	S	T	Q	N	A	S	G	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																																									?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	S	G	P	F	Y	D	G	A	V	F	H	R	V	I	Q	G	F	M	I	Q	G	G	D	P	T	G	T	G	R	G	G	P	G	Y	K	F	A	D	E	F	H	P	E	L	Q	F	D	K	P	Y	L	L	A	M	A	N	A	G	P
Secondary structure
SS confidence
Disorder		?																										?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	T	N	G	S	Q	F	F	I	T	V	G	K	T	P	H	L	N	R	R	H	T	I	F	G	E	V	I	D	A	E	S	Q	R	V	V	E	A	I	S	K	T	A	T	D	G	N	D	R	P	T	D	P	V	V	I	E	S	I	T
Secondary structure
SS confidence
Disorder																																										?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.
Sequence		I	S
Secondary structure
SS confidence
Disorder			?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 13%) Beta strand ( 29%)

Rank Aligned region

PDB 1w74 chain A Region: 12 - 182 Aligned: 171 Modelled: 171 Confidence: 100.0% Identity: 100% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2k7n chain A Region: 10 - 182 Aligned: 156 Modelled: 156 Confidence: 100.0% Identity: 48% PDB header:isomerase Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase-like 1; PDBTitle: solution structure of the ppil1 bound to a fragment of skip Phyre2 PDB 1ihg chain A Region: 2 - 181 Aligned: 172 Modelled: 180 Confidence: 100.0% Identity: 36% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin 40; PDBTitle: bovine cyclophilin 40, monoclinic form Phyre2 PDB 2hq6 chain A Region: 6 - 181 Aligned: 160 Modelled: 161 Confidence: 100.0% Identity: 44% PDB header:isomerase Chain: A: PDB Molecule:serologically defined colon cancer antigen 10; PDBTitle: structure of the cyclophilin_cecyp16-like domain of the serologically2 defined colon cancer antigen 10 from homo sapiens Phyre2 PDB 5jhe chain A Region: 14 - 181 Aligned: 162 Modelled: 166 Confidence: 100.0% Identity: 38% PDB header:chaperone Chain: A: PDB Molecule:peptidyl-prolyl cis-trans isomerase cyp7; PDBTitle: the crystal structure of the saccharomyces cerevisiae co-chaperone2 cpr7 Phyre2 PDB 4r3f chain A Region: 8 - 181 Aligned: 157 Modelled: 159 Confidence: 100.0% Identity: 46% PDB header:isomerase Chain: A: PDB Molecule:spliceosomal protein cwc27; PDBTitle: structure of the spliceosomal peptidyl-prolyl cis-trans isomerase2 cwc27 from chaetomium thermophilum Phyre2 PDB 2fu0 chain A domain 1 Region: 15 - 182 Aligned: 151 Modelled: 153 Confidence: 100.0% Identity: 45% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2a2n chain A domain 1 Region: 10 - 181 Aligned: 155 Modelled: 155 Confidence: 100.0% Identity: 50% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1ihg chain A domain 2 Region: 2 - 181 Aligned: 173 Modelled: 176 Confidence: 100.0% Identity: 33% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 3bo7 chain D Region: 12 - 181 Aligned: 153 Modelled: 153 Confidence: 100.0% Identity: 36% PDB header:isomerase/immunosuppressant Chain: D: PDB Molecule:peptidyl-prolyl cis-trans isomerase cyclophilin-type; PDBTitle: crystal structure of toxoplasma gondii peptidyl-prolyl cis-trans2 isomerase, 541.m00136 Phyre2 PDB 1z81 chain A domain 1 Region: 2 - 181 Aligned: 172 Modelled: 180 Confidence: 100.0% Identity: 35% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1z81 chain A Region: 2 - 181 Aligned: 172 Modelled: 180 Confidence: 100.0% Identity: 35% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin; PDBTitle: crystal structure of cyclophilin from plasmodium yoelii. Phyre2 PDB 1xwn chain A domain 1 Region: 9 - 182 Aligned: 157 Modelled: 157 Confidence: 100.0% Identity: 48% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 1zkc chain A domain 1 Region: 15 - 181 Aligned: 150 Modelled: 152 Confidence: 100.0% Identity: 45% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2rmc chain A Region: 9 - 181 Aligned: 159 Modelled: 161 Confidence: 100.0% Identity: 47% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2b71 chain A Region: 13 - 180 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 40% PDB header:isomerase Chain: A: PDB Molecule:cyclophilin-like protein; PDBTitle: plasmodium yoelii cyclophilin-like protein Phyre2 PDB 2b71 chain A domain 1 Region: 13 - 180 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 40% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2ok3 chain A domain 1 Region: 15 - 181 Aligned: 150 Modelled: 152 Confidence: 100.0% Identity: 49% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2esl chain A domain 1 Region: 10 - 181 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 47% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: Cyclophilin (peptidylprolyl isomerase) Phyre2 PDB 2he9 chain B Region: 14 - 181 Aligned: 162 Modelled: 168 Confidence: 100.0% Identity: 36% PDB header:isomerase Chain: B: PDB Molecule:nk-tumor recognition protein; PDBTitle: structure of the peptidylprolyl isomerase domain of the human nk-2 tumour recognition protein Phyre2 1 d1w74a_ 2 c2k7nA_ 3 c1ihgA_ 4 c2hq6A_ 5 c5jheA_ 6 c4r3fA_ 7 d2fu0a1 8 d2a2na1 9 d1ihga2 10 c3bo7D_ 11 d1z81a1 12 c1z81A_ 13 d1xwna1 14 d1zkca1 15 d2rmca_ 16 c2b71A_ 17 d2b71a1 18 d2ok3a1 19 d2esla1 20 c2he9B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64