1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	R	L	Q	A	P	V	A	V	T	P	P	L	P	T	R	R	N	A	E	L	L	L	L	C	F	A	A	V	I	T	F	A	A	L	L	V	V	Q	A	N	Q	D	Q	G	V	P	W	D	L	T	S	Y	G	L	A	F	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?																										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	L	F	G	S	A	H	L	A	I	R	R	F	A	P	Y	T	D	P	L	L	L	P	V	V	A	L	L	N	G	L	G	L	V	M	I	H	R	L	D	L	V	D	N	E	I	G	E	H	R	H	P	S	A	N	Q	Q	M	L	W
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	L	V	G	V	A	A	F	A	L	V	V	T	F	L	K	D	H	R	Q	L	A	R	Y	G	Y	I	C	G	L	A	G	L	V	F	L	A	V	P	A	L	L	P	A	A	L	S	E	Q	N	G	A	K	I	W	I	R	L	P	G
Secondary structure
SS confidence
Disorder																																											?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		F	S	I	Q	P	A	E	F	S	K	I	L	L	L	I	F	F	S	A	V	L	V	A	K	R	G	L	F	T	S	A	G	K	H	L	L	G	M	T	L	P	R	P	R	D	L	A	P	L	L	A	A	W	V	I	S	V	G	V	M
Secondary structure
SS confidence
Disorder																													?	?	?	?		?	?	?		?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	F	E	K	D	L	G	A	S	L	L	L	Y	T	S	F	L	V	V	V	Y	L	A	T	Q	R	F	S	W	V	V	I	G	L	T	L	F	A	A	G	T	L	V	A	Y	F	I	F	E	H	V	R	L	R	V	Q	T	W	L	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		P	F	A	D	P	D	G	T	G	Y	Q	I	V	Q	S	L	F	S	F	A	T	G	G	I	F	G	T	G	L	G	N	G	Q	P	D	T	V	P	A	A	S	T	D	F	I	I	A	A	F	G	E	E	L	G	L	V	G	L	T	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	L	M	L	Y	T	I	V	I	I	R	G	L	R	T	A	I	A	T	R	D	S	F	G	K	L	L	A	A	G	L	S	S	T	L	A	I	Q	L	F	I	V	V	G	G	V	T	R	L	I	P	L	T	G	L	T	T	P	W	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.
Sequence		S	Y	G	G	S	S	L	L	A	N	Y	I	L	L	A	I	L	A	R	I	S	H	G	A	R	R	P	L	R	T	R	P	R	N	K	S	P	I	T	A	A	G	T	E	V	I	E	R	V
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 69%) Beta strand ( 1%) TM helix ( 45%) (View membrane topology prediction)

Rank Aligned region

PDB 6bas chain A Region: 75 - 447 Aligned: 297 Modelled: 320 Confidence: 100.0% Identity: 30% PDB header:transferase Chain: A: PDB Molecule:peptidoglycan glycosyltransferase roda; PDBTitle: crystal structure of thermus thermophilus rod shape determining2 protein roda d255a mutant (q5six3_thet8) Phyre2 PDB 6ied chain A Region: 324 - 457 Aligned: 124 Modelled: 134 Confidence: 61.9% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:heme a synthase; PDBTitle: crystal structure of heme a synthase from bacillus subtilis Phyre2 PDB 2jo1 chain A Region: 423 - 463 Aligned: 41 Modelled: 41 Confidence: 47.1% Identity: 27% PDB header:hydrolase regulator Chain: A: PDB Molecule:phospholemman; PDBTitle: structure of the na,k-atpase regulatory protein fxyd1 in2 micelles Phyre2 PDB 4mt1 chain A Region: 341 - 465 Aligned: 109 Modelled: 109 Confidence: 36.7% Identity: 11% PDB header:membrane protein, tranport protein Chain: A: PDB Molecule:drug efflux protein; PDBTitle: crystal structure of the neisseria gonorrhoeae mtrd inner membrane2 multidrug efflux pump Phyre2 PDB 6csx chain A Region: 341 - 465 Aligned: 109 Modelled: 109 Confidence: 35.4% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:multidrug efflux pump subunit acrb; PDBTitle: single particles cryo-em structure of acrb d407a associated with lipid2 bilayer at 3.0 angstrom Phyre2 PDB 6dmo chain A Region: 342 - 465 Aligned: 116 Modelled: 124 Confidence: 30.7% Identity: 11% PDB header:protein binding Chain: A: PDB Molecule:protein patched homolog 1; PDBTitle: cryo-em structure of human ptch1 with three mutations2 l282q/t500f/p504l Phyre2 PDB 6ows chain B Region: 341 - 465 Aligned: 109 Modelled: 109 Confidence: 30.6% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:efflux pump membrane transporter; PDBTitle: cryo-em structure of an acinetobacter baumannii multidrug efflux pump Phyre2 PDB 5ejd chain K Region: 414 - 433 Aligned: 20 Modelled: 20 Confidence: 30.6% Identity: 20% PDB header:biosynthetic protein Chain: K: PDB Molecule:tqaa; PDBTitle: the crystal structure of holo t3ct Phyre2 PDB 2knc chain B Region: 353 - 375 Aligned: 23 Modelled: 23 Confidence: 28.6% Identity: 26% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2v50 chain A Region: 341 - 465 Aligned: 109 Modelled: 109 Confidence: 26.9% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein mexb; PDBTitle: the missing part of the bacterial mexab-oprm system: structural2 determination of the multidrug exporter mexb Phyre2 PDB 2aze chain A domain 1 Region: 411 - 420 Aligned: 10 Modelled: 10 Confidence: 26.1% Identity: 20% Fold: E2F-DP heterodimerization region Superfamily: E2F-DP heterodimerization region Family: DP dimerization segment Phyre2 PDB 4pxh chain F Region: 406 - 436 Aligned: 30 Modelled: 31 Confidence: 22.1% Identity: 23% PDB header:oxidoreductase/protein binding Chain: F: PDB Molecule:peptide synthetase; PDBTitle: structure of p450sky (cyp163b3), a cytochrome p450 from skyllamycin2 biosynthesis in complex with a peptidyl carrier protein domain Phyre2 PDB 2mr7 chain A Region: 398 - 433 Aligned: 35 Modelled: 36 Confidence: 21.4% Identity: 23% PDB header:biosynthetic protein Chain: A: PDB Molecule:non-ribosomal peptide synthetase; PDBTitle: apo structure of the peptidyl carrier protein domain 7 of the2 teicoplanin producing non-ribosomal peptide synthetase Phyre2 PDB 6nbx chain G Region: 346 - 465 Aligned: 120 Modelled: 120 Confidence: 19.0% Identity: 17% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 5zk4 chain D Region: 414 - 436 Aligned: 23 Modelled: 23 Confidence: 18.0% Identity: 17% PDB header:transferase Chain: D: PDB Molecule:disa protein; PDBTitle: the structure of dszs acyltransferase with carrier protein Phyre2 PDB 2png chain A domain 1 Region: 403 - 430 Aligned: 28 Modelled: 28 Confidence: 17.9% Identity: 18% Fold: Acyl carrier protein-like Superfamily: ACP-like Family: Acyl-carrier protein (ACP) Phyre2 PDB 2gdw chain A domain 1 Region: 403 - 430 Aligned: 27 Modelled: 28 Confidence: 13.8% Identity: 26% Fold: Acyl carrier protein-like Superfamily: ACP-like Family: Peptidyl carrier domain Phyre2 PDB 1iwg chain A domain 8 Region: 378 - 467 Aligned: 90 Modelled: 90 Confidence: 13.4% Identity: 11% Fold: Multidrug efflux transporter AcrB transmembrane domain Superfamily: Multidrug efflux transporter AcrB transmembrane domain Family: Multidrug efflux transporter AcrB transmembrane domain Phyre2 PDB 4i4d chain A Region: 410 - 429 Aligned: 20 Modelled: 20 Confidence: 13.3% Identity: 25% PDB header:biosynthetic protein Chain: A: PDB Molecule:peptide synthetase nrps type ii-pcp; PDBTitle: structure of blmi, a type-ii acyl-carrier-protein from streptomyces2 verticillus involved in bleomycin biosynthesis Phyre2 PDB 2jp3 chain A Region: 423 - 459 Aligned: 37 Modelled: 37 Confidence: 11.5% Identity: 14% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 1 c6basA_ 2 c6iedA_ 3 c2jo1A_ 4 c4mt1A_ 5 c6csxA_ 6 c6dmoA_ 7 c6owsB_ 8 c5ejdK_ 9 c2kncB_ 10 c2v50A_ 11 d2azea1 12 c4pxhF_ 13 c2mr7A_ 14 c6nbxG_ 15 c5zk4D_ 16 d2pnga1 17 d2gdwa1 18 d1iwga8 19 c4i4dA_ 20 c2jp3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36