1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	H	P	C	A	T	D	P	E	L	W	F	G	Y	P	D	D	D	G	S	D	G	A	A	K	A	R	A	Y	E	R	S	A	T	Q	A	R	I	Q	C	L	R	R	C	P	L	L	Q	Q	R	R	C	A	Q	H	A	V	E	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	V	E	Y	G	V	W	A	G	I	K	L	P	G	G	Q	Y	R	K	R	E	Q	L	A	A	A	H	D	V	L	R	R	I	A	G	G	E	I	N	S	R	Q	L	P	D	N	A	A	L	L	A	R	N	E	G	L	E	V	T	P
Secondary structure
SS confidence
Disorder																?	?	?	?	?																		?	?	?	?		?	?		?		?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.
Sequence		V	P	G	V	V	V	H	L	P	I	A	Q	V	G	P	Q	P	A	A
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 31%) Alpha helix ( 58%) Beta strand ( 5%)

Rank Aligned region

PDB 5oay chain A Region: 7 - 70 Aligned: 52 Modelled: 64 Confidence: 98.0% Identity: 35% PDB header:signaling protein Chain: A: PDB Molecule:transcriptional regulator whib1; PDBTitle: m. tuberculosis [4fe-4s] protein whib1 is a four-helix bundle that2 forms a no-sensitive complex with sigmaa and regulates the major3 virulence factor esx-1 Phyre2 PDB 2k1o chain A Region: 87 - 100 Aligned: 14 Modelled: 14 Confidence: 50.8% Identity: 64% PDB header:gene regulation Chain: A: PDB Molecule:putative; PDBTitle: nmr structure of helicobacter pylori jhp0511 (hp0564). Phyre2 PDB 2l6t chain A Region: 2 - 16 Aligned: 15 Modelled: 15 Confidence: 26.7% Identity: 53% PDB header:antiviral protein Chain: A: PDB Molecule:vir-576; PDBTitle: efficacy of an hiv-1 entry inhibitor targeting the gp41 fusion peptide Phyre2 PDB 2l6s chain A Region: 2 - 16 Aligned: 15 Modelled: 15 Confidence: 26.7% Identity: 53% PDB header:antiviral protein Chain: A: PDB Molecule:vir-576; PDBTitle: efficacy of an hiv-1 entry inhibitor targeting the gp41 fusion peptide Phyre2 PDB 2jsj chain A Region: 69 - 77 Aligned: 9 Modelled: 9 Confidence: 15.4% Identity: 78% PDB header:hormone Chain: A: PDB Molecule:appetite-regulating hormone, obestatin; PDBTitle: obestatin in water solution Phyre2 PDB 5dmp chain A Region: 60 - 77 Aligned: 17 Modelled: 18 Confidence: 12.1% Identity: 41% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the archaeal nhej phosphoesterase from methanocella2 paludicola. Phyre2 PDB 1ei0 chain A Region: 27 - 45 Aligned: 19 Modelled: 19 Confidence: 11.6% Identity: 47% PDB header:cell cycle Chain: A: PDB Molecule:p8mtcp1; PDBTitle: nmr structure of the alpha-helical hairpin of p8mtcp1 Phyre2 PDB 1aop chain A domain 2 Region: 67 - 102 Aligned: 35 Modelled: 36 Confidence: 11.6% Identity: 14% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 6ba3 chain A Region: 70 - 79 Aligned: 10 Modelled: 10 Confidence: 11.3% Identity: 60% PDB header:toxin Chain: A: PDB Molecule:u21-hexatoxin-hi1a; PDBTitle: nmr structure of u21-hexatoxin-hi1a toxin from australian funnel-web2 spider hadronyche infensa Phyre2 PDB 1gpq chain A Region: 12 - 30 Aligned: 19 Modelled: 19 Confidence: 11.3% Identity: 26% Fold: Inhibitor of vertebrate lysozyme, Ivy Superfamily: Inhibitor of vertebrate lysozyme, Ivy Family: Inhibitor of vertebrate lysozyme, Ivy Phyre2 PDB 2jsh chain A Region: 69 - 77 Aligned: 9 Modelled: 9 Confidence: 10.6% Identity: 78% PDB header:hormone Chain: A: PDB Molecule:appetite-regulating hormone, obestatin; PDBTitle: obestatin nmr structure in sds/dpc micellar solution Phyre2 PDB 1zj8 chain A domain 1 Region: 67 - 98 Aligned: 31 Modelled: 32 Confidence: 10.5% Identity: 23% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 4ce0 chain A Region: 42 - 69 Aligned: 28 Modelled: 28 Confidence: 10.3% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:o-methyltransferase; PDBTitle: crystal structure of sah-bound spinosyn rhamnosyl 4'-o-2 methyltransferase spnh from saccharopolyspora spinosa Phyre2 PDB 3b0n chain A Region: 70 - 102 Aligned: 32 Modelled: 33 Confidence: 9.8% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:nitrite reductase; PDBTitle: q448k mutant of assimilatory nitrite reductase (nii3) from tobbaco2 leaf Phyre2 PDB 6c4v chain A Region: 61 - 109 Aligned: 49 Modelled: 49 Confidence: 9.3% Identity: 29% PDB header:transport protein Chain: A: PDB Molecule:polyketide synthase pks13; PDBTitle: 1.9 angstrom resolution crystal structure of acyl carrier protein2 domain (residues 1350-1461) of polyketide synthase pks13 from3 mycobacterium tuberculosis Phyre2 PDB 3p4h chain A Region: 60 - 77 Aligned: 17 Modelled: 18 Confidence: 9.0% Identity: 35% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent dna ligase, n-terminal domain protein; PDBTitle: structures of archaeal members of the ligd 3'-phosphoesterase dna2 repair enzyme superfamily Phyre2 PDB 5fwh chain A Region: 12 - 20 Aligned: 9 Modelled: 9 Confidence: 8.8% Identity: 56% PDB header:structural protein Chain: A: PDB Molecule:essc; PDBTitle: n-terminal fha domain from essc a component of the2 bacterial type vii secretion apparatus Phyre2 PDB 2wk1 chain A Region: 47 - 69 Aligned: 23 Modelled: 23 Confidence: 8.3% Identity: 39% PDB header:transferase Chain: A: PDB Molecule:novp; PDBTitle: structure of the o-methyltransferase novp Phyre2 PDB 2n6r chain A Region: 70 - 77 Aligned: 8 Modelled: 8 Confidence: 8.0% Identity: 50% PDB header:toxin Chain: A: PDB Molecule:u4-hexatoxin-hi1a; PDBTitle: nmr structure of spider toxin u4-hexatoxin-hi1a Phyre2 PDB 2pkg chain C domain 1 Region: 11 - 21 Aligned: 11 Modelled: 11 Confidence: 7.7% Identity: 36% Fold: T-antigen specific domain-like Superfamily: T-antigen specific domain-like Family: T-antigen specific domain-like Phyre2 1 c5oayA_ 2 c2k1oA_ 3 c2l6tA_ 4 c2l6sA_ 5 c2jsjA_ 6 c5dmpA_ 7 c1ei0A_ 8 d1aopa2 9 c6ba3A_ 10 d1gpqa_ 11 c2jshA_ 12 d1zj8a1 13 c4ce0A_ 14 c3b0nA_ 15 c6c4vA_ 16 c3p4hA_ 17 c5fwhA_ 18 c2wk1A_ 19 c2n6rA_ 20 d2pkgc1 21 22 23 24 25 26 27 28 29 30 31 32 33