1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	I	F	G	R	W	S	A	R	Q	R	L	R	R	A	T	R	E	S	L	T	I	P	T	F	S	S	S	L	D	C	T	T	R	V	I	G	G	L	W	P	A	E	L	S	S	N	T	A	E	T	A	T	L	A	E	H	L	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?											?	?				?	?																						?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	D	L	H	R	I	V	G	S	A	N	D	E	L	M	V	I	W	R	A	G	M	A	D	S	T	R	R	A	E	E	D	R	V	I	D	R	A	R	A	S	A	M	R	R	V	E	S	A	M	R	E	L	R	Q	I	T	G	R	V
Secondary structure
SS confidence
Disorder																						?		?	?	?	?																													?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	V	E	I	P	R	M	R	G	A	G	G	S	D	L	D	T	T	R	L	M	P	A	V	T	V	V	Q	P	A	D	Q	A	C	T	D	W	P	V	A	A	A	E	D	D	E	A	R	L	Q	R	L	L	A	F	V	A	R	Q	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	R	L	N	W	A	V	G	V	H	A	D	G	T	T	V	L	V	T	D	V	A	H	G	W	I	P	P	G	I	A	L	P	E	G	V	R	L	L	A	P	A	R	R	A	G	R	A	P	E	L	V	G	I	T	T	C	C	K	T
Secondary structure
SS confidence
Disorder																																			?									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	T	P	G	D	S	L	R	R	A	V	D	S	T	A	P	T	S	S	V	Q	P	R	A	L	P	A	I	A	G	L	S	V	E	L	G	I	A	T	Q	R	H	D	G	L	P	K	I	V	H	A	M	A	T	A	A	G	N	G	A
Secondary structure
SS confidence
Disorder									?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?	?	?															?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	A	E	E	V	D	L	L	R	V	H	V	D	T	A	L	H	H	V	L	A	Q	Y	P	R	V	D	P	A	L	L	L	N	C	M	L	L	A	A	T	E	R	S	V	T	G	D	P	I	A	A	N	Y	H	F	A	W	F	R	E
Secondary structure
SS confidence
Disorder																																											?	?	?	?
Disorder confidence
		.	.	.	.	.
Sequence		L	D	S	R	R
Secondary structure
SS confidence
Disorder				?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 56%) Beta strand ( 2%)

Rank Aligned region

PDB 5imu chain A Region: 156 - 364 Aligned: 209 Modelled: 209 Confidence: 100.0% Identity: 34% PDB header:signaling protein Chain: A: PDB Molecule:tat (twin-arginine translocation) pathway signal sequence PDBTitle: a fragment of conserved hypothetical protein rv3899c (residues 184-2 410) from mycobacterium tuberculosis Phyre2 PDB 5gan chain C Region: 243 - 286 Aligned: 37 Modelled: 44 Confidence: 42.5% Identity: 24% PDB header:transcription Chain: C: PDB Molecule:pre-mrna-splicing factor snu114; PDBTitle: the overall structure of the yeast spliceosomal u4/u6.u5 tri-snrnp at2 3.7 angstrom Phyre2 PDB 3jb9 chain B Region: 243 - 286 Aligned: 37 Modelled: 44 Confidence: 37.3% Identity: 27% PDB header:rna binding protein/rna Chain: B: PDB Molecule:pre-mrna-splicing factor cwf10; PDBTitle: cryo-em structure of the yeast spliceosome at 3.6 angstrom resolution Phyre2 PDB 5mqf chain B Region: 243 - 286 Aligned: 37 Modelled: 37 Confidence: 35.5% Identity: 35% PDB header:splicing Chain: B: PDB Molecule:116 kda u5 small nuclear ribonucleoprotein component; PDBTitle: cryo-em structure of a human spliceosome activated for step 2 of2 splicing (c* complex) Phyre2 PDB 1afr chain A Region: 237 - 361 Aligned: 122 Modelled: 125 Confidence: 35.1% Identity: 20% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 6ckn chain A Region: 306 - 335 Aligned: 30 Modelled: 25 Confidence: 35.0% Identity: 20% PDB header:dna binding protein Chain: A: PDB Molecule:protein af-10; PDBTitle: crystal structure of an af10 fragment Phyre2 PDB 5lj3 chain C Region: 243 - 286 Aligned: 37 Modelled: 44 Confidence: 32.1% Identity: 24% PDB header:splicing Chain: C: PDB Molecule:pre-mrna-splicing factor snu114; PDBTitle: structure of the core of the yeast spliceosome immediately after2 branching Phyre2 PDB 3en0 chain A Region: 164 - 200 Aligned: 34 Modelled: 37 Confidence: 24.5% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:cyanophycinase; PDBTitle: the structure of cyanophycinase Phyre2 PDB 1bol chain A Region: 35 - 42 Aligned: 8 Modelled: 8 Confidence: 23.8% Identity: 50% Fold: Ribonuclease Rh-like Superfamily: Ribonuclease Rh-like Family: Ribonuclease Rh-like Phyre2 PDB 3t0o chain A Region: 35 - 42 Aligned: 8 Modelled: 8 Confidence: 22.2% Identity: 63% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease t2; PDBTitle: crystal structure analysis of human rnase t2 Phyre2 PDB 1ioo chain A Region: 35 - 42 Aligned: 8 Modelled: 8 Confidence: 21.0% Identity: 63% Fold: Ribonuclease Rh-like Superfamily: Ribonuclease Rh-like Family: Ribonuclease Rh-like Phyre2 PDB 5z58 chain C Region: 243 - 285 Aligned: 36 Modelled: 43 Confidence: 20.3% Identity: 36% PDB header:splicing Chain: C: PDB Molecule:116 kda u5 small nuclear ribonucleoprotein component; PDBTitle: cryo-em structure of a human activated spliceosome (early bact) at 4.92 angstrom. Phyre2 PDB 1nch chain A Region: 202 - 216 Aligned: 15 Modelled: 15 Confidence: 19.7% Identity: 40% PDB header:cell adhesion protein Chain: A: PDB Molecule:n-cadherin; PDBTitle: structural basis of cell-cell adhesion by cadherins Phyre2 PDB 1iqq chain A Region: 35 - 51 Aligned: 17 Modelled: 17 Confidence: 19.6% Identity: 24% Fold: Ribonuclease Rh-like Superfamily: Ribonuclease Rh-like Family: Ribonuclease Rh-like Phyre2 PDB 2fc6 chain A domain 1 Region: 202 - 214 Aligned: 13 Modelled: 13 Confidence: 19.0% Identity: 46% Fold: CCCH zinc finger Superfamily: CCCH zinc finger Family: CCCH zinc finger Phyre2 PDB 1ucd chain A Region: 35 - 42 Aligned: 8 Modelled: 8 Confidence: 19.0% Identity: 63% Fold: Ribonuclease Rh-like Superfamily: Ribonuclease Rh-like Family: Ribonuclease Rh-like Phyre2 PDB 1sgl chain A Region: 35 - 42 Aligned: 8 Modelled: 8 Confidence: 18.5% Identity: 50% Fold: Ribonuclease Rh-like Superfamily: Ribonuclease Rh-like Family: Ribonuclease Rh-like Phyre2 PDB 1d0g chain R domain 3 Region: 31 - 35 Aligned: 5 Modelled: 5 Confidence: 17.6% Identity: 60% Fold: TNF receptor-like Superfamily: TNF receptor-like Family: TNF receptor-like Phyre2 PDB 1jy5 chain A Region: 29 - 42 Aligned: 14 Modelled: 14 Confidence: 17.5% Identity: 50% Fold: Ribonuclease Rh-like Superfamily: Ribonuclease Rh-like Family: Ribonuclease Rh-like Phyre2 PDB 2mv3 chain A Region: 336 - 361 Aligned: 26 Modelled: 26 Confidence: 16.6% Identity: 23% PDB header:nucleotide binding protein Chain: A: PDB Molecule:mitochondrial inner membrane i-aaa protease supercomplex PDBTitle: the n-domain of the aaa metalloproteinase yme1 from saccharomyces2 cerevisiae Phyre2 1 c5imuA_ 2 c5ganC_ 3 c3jb9B_ 4 c5mqfB_ 5 d1afra_ 6 c6cknA_ 7 c5lj3C_ 8 c3en0A_ 9 d1bola_ 10 c3t0oA_ 11 d1iooa_ 12 c5z58C_ 13 c1nchA_ 14 d1iqqa_ 15 d2fc6a1 16 d1ucda_ 17 d1sgla_ 18 d1d0gr3 19 d1jy5a_ 20 c2mv3A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99