1

.

.

.

.

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.

.

.

10

.

.

.

.

.

.

.

.

.

20

.

.

.

.

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.

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30

.

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.

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40

.

.

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50

.

.

.

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.

.

.

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60

Sequence

L

L

A

R

H

F

G

A

G

R

K

A

H

S

R

A

V

A

T

L

K

A

D

I

Q

A

W

H

P

A

G

I

Q

T

P

K

P

R

C

E

S

D

V

F

A

R

I

G

H

T

S

H

P

S

T

R

K

S

R

V

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

Sequence

G

P

G

A

S

E

A

P

L

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 57%) Alpha helix ( 61%) Beta strand ( 0%)

Rank Aligned region

PDB 1es6 chain A domain 1 Region: 24 - 69 Aligned: 46 Modelled: 46 Confidence: 59.6% Identity: 37% Fold: EV matrix protein Superfamily: EV matrix protein Family: EV matrix protein Phyre2 PDB 1h2c chain A Region: 24 - 69 Aligned: 46 Modelled: 46 Confidence: 47.3% Identity: 37% Fold: EV matrix protein Superfamily: EV matrix protein Family: EV matrix protein Phyre2 PDB 1h2d chain A Region: 24 - 69 Aligned: 46 Modelled: 46 Confidence: 44.8% Identity: 37% PDB header:virus/viral protein Chain: A: PDB Molecule:matrix protein vp40; PDBTitle: ebola virus matrix protein vp40 n-terminal domain in complex with rna2 (low-resolution vp40[31-212] variant). Phyre2 PDB 1es6 chain A Region: 24 - 69 Aligned: 46 Modelled: 46 Confidence: 41.7% Identity: 37% PDB header:viral protein Chain: A: PDB Molecule:matrix protein vp40; PDBTitle: crystal structure of the matrix protein of ebola virus Phyre2 PDB 3tcq chain A Region: 24 - 69 Aligned: 46 Modelled: 46 Confidence: 41.0% Identity: 37% PDB header:viral protein Chain: A: PDB Molecule:matrix protein vp40; PDBTitle: crystal structure of matrix protein vp40 from ebola virus sudan Phyre2 PDB 5b0v chain A Region: 24 - 69 Aligned: 46 Modelled: 46 Confidence: 35.3% Identity: 30% PDB header:viral protein Chain: A: PDB Molecule:matrix protein vp40; PDBTitle: crystal structure of marburg virus vp40 dimer Phyre2 PDB 2oip chain E Region: 4 - 39 Aligned: 36 Modelled: 36 Confidence: 15.6% Identity: 36% PDB header:transferase, oxidoreductase Chain: E: PDB Molecule:chain a, crystal structure of dhfr; PDBTitle: crystal structure of the s290g active site mutant of ts-dhfr from2 cryptosporidium hominis Phyre2 PDB 3ujj chain P Region: 55 - 63 Aligned: 9 Modelled: 9 Confidence: 11.1% Identity: 89% PDB header:immune system Chain: P: PDB Molecule:gp120; PDBTitle: crystal structure of anti-hiv-1 v3 fab 4025 in complex with con a2 peptide Phyre2 PDB 3clb chain A Region: 4 - 39 Aligned: 36 Modelled: 36 Confidence: 9.9% Identity: 44% PDB header:oxidoreductase, transferase Chain: A: PDB Molecule:dhfr-ts; PDBTitle: structure of bifunctional tcdhfr-ts in complex with tmq Phyre2 PDB 3k2h chain A Region: 4 - 39 Aligned: 36 Modelled: 36 Confidence: 7.3% Identity: 31% PDB header:transferase Chain: A: PDB Molecule:dihydrofolate reductase/thymidylate synthase; PDBTitle: co-crystal structure of dihydrofolate reductase/thymidylate synthase2 from babesia bovis with dump, pemetrexed and nadp Phyre2 PDB 2nsf chain A domain 2 Region: 17 - 34 Aligned: 18 Modelled: 18 Confidence: 7.0% Identity: 39% Fold: SCP-like Superfamily: SCP-like Family: Micothiol-dependent maleylpyruvate isomerase C-terminal domain-like Phyre2 PDB 5aj3 chain N Region: 29 - 36 Aligned: 8 Modelled: 8 Confidence: 6.7% Identity: 88% PDB header:ribosome Chain: N: PDB Molecule:mitoribosomal protein us14m, mrps14; PDBTitle: structure of the small subunit of the mammalian mitoribosome Phyre2 PDB 1yuj chain A Region: 28 - 42 Aligned: 15 Modelled: 15 Confidence: 5.9% Identity: 40% Fold: beta-beta-alpha zinc fingers Superfamily: beta-beta-alpha zinc fingers Family: Classic zinc finger, C2H2 Phyre2 1 d1es6a1 2 d1h2ca_ 3 c1h2dA_ 4 c1es6A_ 5 c3tcqA_ 6 c5b0vA_ 7 c2oipE_ 8 c3ujjP_ 9 c3clbA_ 10 c3k2hA_ 11 d2nsfa2 12 c5aj3n_ 13 d1yuja_