1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	T	R	Y	K	P	E	S	G	F	V	A	R	S	G	G	P	D	R	K	R	P	H	D	W	I	V	W	H	F	T	H	A	D	N	L	P	G	I	I	T	A	G	R	L	L	A	D	S	A	V	T	P	T	T	E	V	A	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?						?	?	?	?	?	?	?	?	?	?																													?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	P	V	K	E	L	R	R	H	K	V	V	A	P	D	S	R	Y	P	A	S	M	A	S	D	H	V	P	F	Y	I	A	A	R	S	P	M	L	Y	V	V	C	K	G	H	S	G	Y	S	G	G	A	G	P	L	V	H	L	G	V
Secondary structure
SS confidence
Disorder								?					?	?	?		?	?	?																										?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	L	G	D	I	I	D	A	D	L	T	W	C	A	S	D	G	N	A	A	A	S	Y	T	K	F	S	R	Q	V	D	T	L	G	T	F	V	D	F	D	L	L	C	Q	R	Q	W	H	N	T	D	D	D	P	N	R	Q	S	R	R
Secondary structure
SS confidence
Disorder																																																?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230
Sequence		A	A	E	I	L	V	Y	G	H	V	P	F	E	L	V	S	Y	V	C	C	Y	N	T	E	T	M	T	R	V	R	T	L	L	D	P	V	G	G	V	R	K	Y	V	I	K	P	G	M	Y	Y
Secondary structure
SS confidence
Disorder																																															?	?	?		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 31%) Beta strand ( 24%)

Rank Aligned region

PDB 1wfx chain A Region: 18 - 138 Aligned: 79 Modelled: 80 Confidence: 95.8% Identity: 19% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: Tpt1/KptA Phyre2 PDB 6ede chain A Region: 18 - 138 Aligned: 79 Modelled: 84 Confidence: 95.7% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:probable rna 2'-phosphotransferase; PDBTitle: trna 2'-phosphotransferase Phyre2 PDB 1gs0 chain A domain 2 Region: 18 - 56 Aligned: 39 Modelled: 39 Confidence: 90.4% Identity: 23% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: Poly(ADP-ribose) polymerase, C-terminal domain Phyre2 PDB 2pax chain A Region: 20 - 56 Aligned: 37 Modelled: 37 Confidence: 87.8% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:poly(adp-ribose) polymerase; PDBTitle: the catalytic fragment of poly(adp-ribose) polymerase2 complexed with 4-amino-1,8-naphthalimide Phyre2 PDB 1gs0 chain B Region: 18 - 56 Aligned: 39 Modelled: 39 Confidence: 87.4% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:poly (adp-ribose) polymerase-2; PDBTitle: crystal structure of the catalytic fragment of murine poly2 (adp-ribose) polymerase-2 Phyre2 PDB 2rd6 chain A domain 2 Region: 27 - 56 Aligned: 30 Modelled: 30 Confidence: 84.5% Identity: 27% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: Poly(ADP-ribose) polymerase, C-terminal domain Phyre2 PDB 3c4h chain A Region: 20 - 48 Aligned: 29 Modelled: 29 Confidence: 81.5% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:poly(adp-ribose) polymerase 3; PDBTitle: human poly(adp-ribose) polymerase 3, catalytic fragment in complex2 with an inhibitor dr2313 Phyre2 PDB 4dqy chain F Region: 20 - 56 Aligned: 37 Modelled: 37 Confidence: 81.4% Identity: 22% PDB header:transferase/dna Chain: F: PDB Molecule:poly [adp-ribose] polymerase 1; PDBTitle: structure of human parp-1 bound to a dna double strand break Phyre2 PDB 1efy chain A domain 2 Region: 20 - 56 Aligned: 37 Modelled: 37 Confidence: 79.8% Identity: 22% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: Poly(ADP-ribose) polymerase, C-terminal domain Phyre2 PDB 2x5y chain A Region: 27 - 45 Aligned: 19 Modelled: 19 Confidence: 66.6% Identity: 11% PDB header:immune system Chain: A: PDB Molecule:zinc finger ccch-type antiviral protein 1; PDBTitle: human zc3hav1 (artd13), c-terminal domain Phyre2 PDB 3goy chain D Region: 23 - 45 Aligned: 23 Modelled: 23 Confidence: 62.8% Identity: 22% PDB header:transferase/transferase inhibitor Chain: D: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: crystal structure of human poly(adp-ribose) polymerase 14, catalytic2 fragment in complex with an inhibitor 3-aminobenzamide Phyre2 PDB 3blj chain A Region: 23 - 45 Aligned: 23 Modelled: 23 Confidence: 58.8% Identity: 26% PDB header:transferase Chain: A: PDB Molecule:poly(adp-ribose) polymerase 15; PDBTitle: crystal structure of human poly(adp-ribose) polymerase 15, catalytic2 fragment Phyre2 PDB 5ngo chain A Region: 27 - 45 Aligned: 19 Modelled: 19 Confidence: 58.3% Identity: 16% PDB header:plant protein Chain: A: PDB Molecule:inactive poly [adp-ribose] polymerase rcd1; PDBTitle: crystal structure of the parp domain of arabidopsis radical-induced2 cell death1 Phyre2 PDB 3hkv chain A Region: 27 - 48 Aligned: 22 Modelled: 22 Confidence: 55.2% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 10; PDBTitle: human poly(adp-ribose) polymerase 10, catalytic fragment in complex2 with an inhibitor 3-aminobenzamide Phyre2 PDB 2pqf chain F Region: 27 - 45 Aligned: 19 Modelled: 19 Confidence: 52.8% Identity: 21% PDB header:transferase Chain: F: PDB Molecule:poly [adp-ribose] polymerase 12; PDBTitle: human poly(adp-ribose) polymerase 12, catalytic fragment in complex2 with an inhibitor 3-aminobenzoic acid Phyre2 PDB 1s1i chain L Region: 5 - 82 Aligned: 78 Modelled: 78 Confidence: 46.8% Identity: 19% PDB header:ribosome Chain: L: PDB Molecule:60s ribosomal protein l15-a; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from yeast2 obtained by docking atomic models for rna and protein components into3 a 11.7 a cryo-em map. this file, 1s1i, contains 60s subunit. the 40s4 ribosomal subunit is in file 1s1h. Phyre2 PDB 3j39 chain N Region: 5 - 43 Aligned: 39 Modelled: 38 Confidence: 41.9% Identity: 31% PDB header:ribosome Chain: N: PDB Molecule:60s ribosomal protein l15; PDBTitle: structure of the d. melanogaster 60s ribosomal proteins Phyre2 PDB 2o0q chain A domain 1 Region: 26 - 125 Aligned: 65 Modelled: 65 Confidence: 35.6% Identity: 11% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: CC0527-like Phyre2 PDB 3zf7 chain Q Region: 5 - 43 Aligned: 39 Modelled: 39 Confidence: 31.0% Identity: 31% PDB header:ribosome Chain: Q: PDB Molecule:ribosomal protein l15; PDBTitle: high-resolution cryo-electron microscopy structure of the trypanosoma2 brucei ribosome Phyre2 PDB 3mhk chain A Region: 27 - 50 Aligned: 22 Modelled: 24 Confidence: 27.6% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:tankyrase-2; PDBTitle: human tankyrase 2 - catalytic parp domain in complex with 2-(2-2 pyridyl)-7,8-dihydro-5h-thiino[4,3-d]pyrimidin-4-ol Phyre2 1 d1wfxa_ 2 c6edeA_ 3 d1gs0a2 4 c2paxA_ 5 c1gs0B_ 6 d2rd6a2 7 c3c4hA_ 8 c4dqyF_ 9 d1efya2 10 c2x5yA_ 11 c3goyD_ 12 c3bljA_ 13 c5ngoA_ 14 c3hkvA_ 15 c2pqfF_ 16 c1s1iL_ 17 c3j39N_ 18 d2o0qa1 19 c3zf7Q_ 20 c3mhkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57