1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	T	Y	G	S	G	D	L	L	R	A	D	T	E	A	L	V	N	T	V	N	C	V	G	V	M	G	K	G	I	A	L	Q	F	K	R	R	Y	P	E	M	F	T	A	Y	E	K	A	C	K	R	G	E	V	T	I	G	K	M
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	V	V	D	T	G	Q	L	D	G	P	K	H	I	I	N	F	P	T	K	K	H	W	R	A	P	S	K	L	A	Y	I	D	A	G	L	I	D	L	I	R	V	I	R	E	L	N	I	A	S	V	A	V	P	P	L	G	V	G	N
Secondary structure
SS confidence
Disorder																						?		?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	G	L	D	W	E	D	V	E	Q	R	L	V	S	A	F	Q	Q	L	P	D	V	D	A	V	I	Y	P	P	S	G	G	S	R	A	I	E	G	V	E	G	L	R	M	T	W	G	R	A	V	I	L	E	A	M	R	R	Y	L	Q
Secondary structure
SS confidence
Disorder																																		?	?			?	?	?	?	?	?	?	?	?	?	?	?											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Q	R	R	A	M	E	P	W	E	D	P	A	G	I	S	H	L	E	I	Q	K	L	M	Y	F	A	N	E	A	D	P	D	L	A	L	D	F	T	P	G	R	Y	G	P	Y	S	E	R	V	R	H	L	L	Q	G	M	E	G	A	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	V	G	L	G	D	G	T	A	R	V	L	A	N	Q	P	I	S	L	T	T	K	G	T	D	A	I	T	D	Y	L	A	T	D	A	A	A	D	R	V	S	A	A	V	D	T	V	L	R	V	I	E	G	F	E	G	P	Y	G	V
Secondary structure
SS confidence
Disorder								?	?	?	?	?																						?	?	?	?	?																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.
Sequence		E	L	L	A	S	T	H	W	V	A	T	R	E	G	A	K	E	P	A	T	A	A	A	A	V	R	K	W	T	K	R	K	G	R	I	Y	S	D	D	R	I	G	V	A	L	D	R	I	L	M	T	A
Secondary structure
SS confidence
Disorder																?	?	?															?	?	?	?		?												?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 53%) Beta strand ( 13%)

Rank Aligned region

PDB 5m3i chain B Region: 1 - 150 Aligned: 150 Modelled: 150 Confidence: 100.0% Identity: 100% PDB header:antitoxin Chain: B: PDB Molecule:rnase iii inhibitor; PDBTitle: macrodomain of mycobacterium tuberculosis darg Phyre2 PDB 5m31 chain A Region: 1 - 149 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 56% PDB header:antitoxin Chain: A: PDB Molecule:appr-1-p processing domain protein; PDBTitle: macrodomain of thermus aquaticus darg Phyre2 PDB 5e3b chain A Region: 2 - 149 Aligned: 140 Modelled: 148 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:macrodomain protein; PDBTitle: structure of macrodomain protein from streptomyces coelicolor Phyre2 PDB 2eee chain A Region: 2 - 147 Aligned: 136 Modelled: 146 Confidence: 100.0% Identity: 24% PDB header:gene regulation Chain: A: PDB Molecule:uncharacterized protein c6orf130; PDBTitle: solution structure of the a1pp domain from human protein2 c6orf130 Phyre2 PDB 2fg1 chain A domain 1 Region: 2 - 148 Aligned: 142 Modelled: 147 Confidence: 100.0% Identity: 22% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 5iit chain C Region: 2 - 149 Aligned: 146 Modelled: 148 Confidence: 100.0% Identity: 18% PDB header:inositol phosphate binding protein Chain: C: PDB Molecule:vacuolar transporter chaperone 4,core histone macro-h2a.1; PDBTitle: structure of spx domain of the yeast inorganic polyphophate polymerase2 vtc4 crystallized by carrier-driven crystallization in fusion with3 the macro domain of human histone macroh2a1.1 Phyre2 PDB 2dx6 chain B Region: 2 - 151 Aligned: 145 Modelled: 150 Confidence: 100.0% Identity: 23% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein ttha0132; PDBTitle: crystal structure of conserved hypothetical protein, ttha0132 from2 thermus thermophilus hb8 Phyre2 PDB 3q71 chain A Region: 2 - 148 Aligned: 146 Modelled: 147 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8) - macro domain 2 in complex with adenosine-5-2 diphosphoribose Phyre2 PDB 3vfq chain A Region: 2 - 149 Aligned: 147 Modelled: 148 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8, bal2) - macro domains 1 and 2 in complex with2 adenosine-5-diphosphoribose Phyre2 PDB 1zr5 chain A domain 1 Region: 2 - 149 Aligned: 146 Modelled: 148 Confidence: 100.0% Identity: 16% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 1zr5 chain B Region: 2 - 149 Aligned: 146 Modelled: 147 Confidence: 100.0% Identity: 16% PDB header:gene regulation Chain: B: PDB Molecule:h2afy protein; PDBTitle: crystal structure of the macro-domain of human core histone variant2 macroh2a1.2 Phyre2 PDB 1spv chain A Region: 2 - 149 Aligned: 147 Modelled: 148 Confidence: 100.0% Identity: 17% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 1yd9 chain A domain 1 Region: 2 - 149 Aligned: 146 Modelled: 148 Confidence: 100.0% Identity: 17% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 2xd7 chain B Region: 2 - 148 Aligned: 145 Modelled: 147 Confidence: 100.0% Identity: 16% PDB header:dna binding protein Chain: B: PDB Molecule:core histone macro-h2a.2; PDBTitle: crystal structure of the macro domain of human core histone h2a Phyre2 PDB 5l9k chain B Region: 2 - 149 Aligned: 147 Modelled: 148 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:macrod-type macrodomain; PDBTitle: oceanobacillus iheyensis macrodomain with adpr Phyre2 PDB 3q6z chain A Region: 2 - 149 Aligned: 147 Modelled: 148 Confidence: 99.9% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:poly [adp-ribose] polymerase 14; PDBTitle: human parp14 (artd8)-macro domain 1 in complex with adenosine-5-2 diphosphoribose Phyre2 PDB 5iq5 chain A Region: 2 - 147 Aligned: 135 Modelled: 146 Confidence: 99.9% Identity: 24% PDB header:viral protein Chain: A: PDB Molecule:macro domain; PDBTitle: nmr solution structure of mayaro virus macro domain Phyre2 PDB 4iqy chain B Region: 2 - 149 Aligned: 145 Modelled: 148 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:o-acetyl-adp-ribose deacetylase macrod2; PDBTitle: crystal structure of the human protein-proximal adp-ribosyl-hydrolase2 macrod2 Phyre2 PDB 1vhu chain A Region: 2 - 149 Aligned: 148 Modelled: 148 Confidence: 99.9% Identity: 21% Fold: Macro domain-like Superfamily: Macro domain-like Family: Macro domain Phyre2 PDB 5ail chain A Region: 2 - 150 Aligned: 142 Modelled: 149 Confidence: 99.9% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:poly [adp-ribose] polymerase 9; PDBTitle: human parp9 2nd macrodomain Phyre2 1 c5m3iB_ 2 c5m31A_ 3 c5e3bA_ 4 c2eeeA_ 5 d2fg1a1 6 c5iitC_ 7 c2dx6B_ 8 c3q71A_ 9 c3vfqA_ 10 d1zr5a1 11 c1zr5B_ 12 d1spva_ 13 d1yd9a1 14 c2xd7B_ 15 c5l9kB_ 16 c3q6zA_ 17 c5iq5A_ 18 c4iqyB_ 19 d1vhua_ 20 c5ailA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102