1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	I	S	V	F	D	L	F	T	I	G	I	G	P	S	S	S	H	T	V	G	P	M	R	A	A	N	Q	F	V	V	A	L	R	R	R	G	H	L	D	D	L	E	A	M	R	V	D	L	F	G	S	L	A	A	T	G	A	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?				?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	G	T	M	S	A	I	L	L	G	L	E	G	C	Q	P	E	T	I	T	T	E	H	K	E	R	R	L	A	E	I	A	A	S	G	V	T	R	I	G	G	V	I	P	V	P	L	T	E	R	D	I	D	L	H	P	D	I	V	L
Secondary structure
SS confidence
Disorder																								?														?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	T	H	P	N	G	M	T	F	T	A	A	G	P	H	G	R	V	L	A	T	E	T	Y	F	S	V	G	G	G	F	I	V	T	E	Q	T	S	G	N	S	G	Q	H	P	C	S	V	A	L	P	Y	V	S	A	Q	E	L	L	D
Secondary structure
SS confidence
Disorder																																							?	?			?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	C	D	R	L	D	V	S	I	S	E	A	A	L	R	N	E	T	C	C	R	T	E	N	E	V	R	A	A	L	L	H	L	R	D	V	M	V	E	C	E	Q	R	S	I	A	R	E	G	L	L	P	G	G	L	R	V	R	R	R
Secondary structure
SS confidence
Disorder																				?	?	?	?																					?			?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	K	V	W	Y	D	R	L	N	A	E	D	P	T	R	K	P	E	F	A	E	D	W	V	N	L	V	A	L	A	V	N	E	E	N	A	S	G	G	R	V	V	T	A	P	T	N	G	A	A	G	I	V	P	A	V	L	H	Y	A
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		I	H	Y	T	S	A	G	A	G	D	P	D	D	V	T	V	R	F	L	L	T	A	G	A	I	G	S	L	F	K	E	R	A	S	I	S	G	A	E	V	G	C	Q	G	E	V	G	S	A	A	A	M	A	A	A	G	L	A	E	I
Secondary structure
SS confidence
Disorder										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	G	G	T	P	R	Q	V	E	N	A	A	E	I	A	M	E	H	S	L	G	L	T	C	D	P	I	A	G	L	V	Q	I	P	C	I	E	R	N	A	I	S	A	G	K	A	I	N	A	A	R	M	A	L	R	G	D	G	I	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Sequence		R	V	T	L	D	Q	V	I	D	T	M	R	A	T	G	A	D	M	H	T	K	Y	K	E	T	S	A	G	G	L	A	I	N	V	A	V	N	I	V	E	C
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 52%) Beta strand ( 8%)

Rank Aligned region

PDB 4rqo chain B Region: 2 - 461 Aligned: 443 Modelled: 460 Confidence: 100.0% Identity: 50% PDB header:lyase Chain: B: PDB Molecule:l-serine dehydratase; PDBTitle: crystal structure of l-serine dehydratase from legionella pneumophila Phyre2 PDB 2iaf chain A domain 1 Region: 17 - 159 Aligned: 138 Modelled: 143 Confidence: 100.0% Identity: 42% Fold: FwdE/GAPDH domain-like Superfamily: Serine metabolism enzymes domain Family: Serine dehydratase beta chain-like Phyre2 PDB 1ygy chain A Region: 23 - 159 Aligned: 114 Modelled: 115 Confidence: 99.7% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:d-3-phosphoglycerate dehydrogenase; PDBTitle: crystal structure of d-3-phosphoglycerate dehydrogenase from2 mycobacterium tuberculosis Phyre2 PDB 1ygy chain A domain 4 Region: 23 - 159 Aligned: 113 Modelled: 115 Confidence: 99.4% Identity: 20% Fold: FwdE/GAPDH domain-like Superfamily: Serine metabolism enzymes domain Family: SerA intervening domain-like Phyre2 PDB 1szq chain A Region: 289 - 417 Aligned: 121 Modelled: 129 Confidence: 97.6% Identity: 20% Fold: 2-methylcitrate dehydratase PrpD Superfamily: 2-methylcitrate dehydratase PrpD Family: 2-methylcitrate dehydratase PrpD Phyre2 PDB 2hp0 chain A Region: 189 - 425 Aligned: 216 Modelled: 237 Confidence: 97.1% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:ids-epimerase; PDBTitle: crystal structure of iminodisuccinate epimerase Phyre2 PDB 5mux chain B Region: 289 - 417 Aligned: 126 Modelled: 129 Confidence: 96.5% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:2-methylcitrate dehydratase; PDBTitle: crystal structure of 2-methylcitrate dehydratase (mmge) from bacillus2 subtilis. Phyre2 PDB 4zhj chain A Region: 12 - 76 Aligned: 63 Modelled: 65 Confidence: 48.9% Identity: 22% PDB header:metal binding protein Chain: A: PDB Molecule:mg-chelatase subunit chlh; PDBTitle: crystal structure of the catalytic subunit of magnesium chelatase Phyre2 PDB 2m2r chain A Region: 378 - 385 Aligned: 8 Modelled: 8 Confidence: 46.6% Identity: 75% PDB header:unknown function Chain: A: PDB Molecule:inhibitor cystine knot peptide mch-2; PDBTitle: solution structure of mch-2: a novel inhibitor cystine knot peptide2 from momordica charantia Phyre2 PDB 2w4e chain A Region: 121 - 157 Aligned: 37 Modelled: 37 Confidence: 45.6% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: structure of an n-terminally truncated nudix hydrolase2 dr2204 from deinococcus radiodurans Phyre2 PDB 3u4g chain A Region: 353 - 382 Aligned: 30 Modelled: 27 Confidence: 36.9% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:namn:dmb phosphoribosyltransferase; PDBTitle: the structure of cobt from pyrococcus horikoshii Phyre2 PDB 6b2z chain D Region: 424 - 444 Aligned: 21 Modelled: 21 Confidence: 35.5% Identity: 24% PDB header:membrane protein Chain: D: PDB Molecule:atp synthase subunit c, mitochondrial; PDBTitle: cryo-em structure of the dimeric fo region of yeast mitochondrial atp2 synthase Phyre2 PDB 3j9e chain D Region: 175 - 222 Aligned: 48 Modelled: 48 Confidence: 35.4% Identity: 21% PDB header:viral protein Chain: D: PDB Molecule:vp5; PDBTitle: atomic structure of a non-enveloped virus reveals ph sensors for a2 coordinated process of cell entry Phyre2 PDB 3s1s chain A Region: 364 - 389 Aligned: 26 Modelled: 26 Confidence: 30.5% Identity: 35% PDB header:hydrolase, transferase Chain: A: PDB Molecule:restriction endonuclease bpusi; PDBTitle: characterization and crystal structure of the type iig restriction2 endonuclease bpusi Phyre2 PDB 1ug2 chain A Region: 176 - 224 Aligned: 48 Modelled: 49 Confidence: 30.0% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Myb/SANT domain Phyre2 PDB 5oyn chain B Region: 283 - 396 Aligned: 93 Modelled: 100 Confidence: 27.4% Identity: 22% PDB header:lyase Chain: B: PDB Molecule:dehydratase, ilvd/edd family; PDBTitle: crystal structure of d-xylonate dehydratase in holo-form Phyre2 PDB 5cag chain A Region: 106 - 156 Aligned: 51 Modelled: 48 Confidence: 26.1% Identity: 27% PDB header:cell adhesion Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative adhesin (bacova_02677) from2 bacteroides ovatus atcc 8483 at 3.00 a resolution (psi community3 target, nakayama) Phyre2 PDB 1no5 chain A Region: 47 - 64 Aligned: 18 Modelled: 18 Confidence: 23.1% Identity: 28% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Catalytic subunit of bi-partite nucleotidyltransferase Phyre2 PDB 1rm6 chain C domain 1 Region: 294 - 319 Aligned: 26 Modelled: 26 Confidence: 22.8% Identity: 12% Fold: CO dehydrogenase ISP C-domain like Superfamily: CO dehydrogenase ISP C-domain like Family: CO dehydrogenase ISP C-domain like Phyre2 PDB 2i7p chain A domain 1 Region: 126 - 184 Aligned: 48 Modelled: 59 Confidence: 22.5% Identity: 25% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Fumble-like Phyre2 1 c4rqoB_ 2 d2iafa1 3 c1ygyA_ 4 d1ygya4 5 d1szqa_ 6 c2hp0A_ 7 c5muxB_ 8 c4zhjA_ 9 c2m2rA_ 10 c2w4eA_ 11 c3u4gA_ 12 c6b2zd_ 13 c3j9eD_ 14 c3s1sA_ 15 d1ug2a_ 16 c5oynB_ 17 c5cagA_ 18 d1no5a_ 19 d1rm6c1 20 d2i7pa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99