1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	S	I	T	V	S	V	D	P	V	D	P	V	D	P	V	D	P	V	D	P	V	D	A	V	V	A	A	G	S	D	G	L	T	V	A	R	I	E	S	E	I	G	A	L	E	F	L	N	E	L	R	T	E	L	K	S	G	Q
Secondary structure
SS confidence
Disorder		?	?						?	?													?	?	?	?	?	?	?	?	?																												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	R	P	Q	P	V	R	E	R	K	I	P	K	P	G	G	L	G	K	V	R	R	L	G	I	P	T	V	A	D	R	V	V	Q	A	A	L	K	L	V	L	E	P	I	F	E	T	D	F	E	P	V	S	Y	G	F	R	P	A	R
Secondary structure
SS confidence
Disorder																?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	A	H	D	T	I	A	E	I	H	L	F	G	T	Q	E	Y	R	W	V	L	D	A	D	I	K	A	C	F	D	R	I	D	H	A	D	L	M	D	R	V	R	H	R	I	K	D	K	R	V	L	R	L	V	N	W	Q	R	I	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.
Sequence		H	R	W	N	W	T	D	V	R	R	W	L	T	D	P	T	G	R	W	H	P	I	S	A	D	G	I	T	L	F	N	P	A	A	V	P	I	R	R	Y	R	Y	R	G	N	T	I	P	T	P	W	T	Q	A	V
Secondary structure
SS confidence
Disorder					?										?	?	?		?																								?	?	?	?				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 51%) Beta strand ( 6%)

Rank Aligned region

PDB 6ar3 chain A Region: 10 - 220 Aligned: 202 Modelled: 211 Confidence: 100.0% Identity: 35% PDB header:rna binding protein/rna/dna Chain: A: PDB Molecule:gsi-iic rt; PDBTitle: structure of a thermostable group ii intron reverse transcriptase with2 template-primer and its functional and evolutionary implications3 (rt/duplex (se-met)) Phyre2 PDB 5g2x chain C Region: 17 - 220 Aligned: 192 Modelled: 204 Confidence: 100.0% Identity: 31% PDB header:transferase Chain: C: PDB Molecule:group ii intron-encoded protein ltra; PDBTitle: structure a of group ii intron complexed with its reverse2 transcriptase Phyre2 PDB 5hhl chain A Region: 11 - 220 Aligned: 201 Modelled: 205 Confidence: 100.0% Identity: 29% PDB header:rna binding protein Chain: A: PDB Molecule:retron-type reverse transcriptase; PDBTitle: reverse transcriptase domain of group ii intron maturase from2 eubacterium rectale in p21 space group Phyre2 PDB 3du6 chain A Region: 67 - 197 Aligned: 119 Modelled: 123 Confidence: 98.5% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:telomerase reverse transcriptase; PDBTitle: structure of the catalytic subunit of telomerase, tert Phyre2 PDB 6d6v chain A Region: 47 - 163 Aligned: 113 Modelled: 114 Confidence: 98.4% Identity: 18% PDB header:replication Chain: A: PDB Molecule:telomerase reverse transcriptase; PDBTitle: cryoem structure of tetrahymena telomerase with telomeric dna at 4.82 angstrom resolution Phyre2 PDB 1xr7 chain A Region: 3 - 167 Aligned: 160 Modelled: 165 Confidence: 95.6% Identity: 14% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 1u09 chain A Region: 4 - 197 Aligned: 192 Modelled: 194 Confidence: 94.7% Identity: 11% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 4nz0 chain F Region: 2 - 197 Aligned: 194 Modelled: 196 Confidence: 93.6% Identity: 14% PDB header:transferase Chain: F: PDB Molecule:genome polyprotein; PDBTitle: the emcv 3dpol structure at 2.8a resolution Phyre2 PDB 1xr6 chain A Region: 3 - 162 Aligned: 154 Modelled: 158 Confidence: 93.1% Identity: 15% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 1rth chain A Region: 7 - 152 Aligned: 111 Modelled: 129 Confidence: 89.2% Identity: 22% PDB header:nucleotidyltransferase Chain: A: PDB Molecule:hiv-1 reverse transcriptase; PDBTitle: high resolution structures of hiv-1 rt from four rt-2 inhibitor complexes Phyre2 PDB 1sh0 chain A Region: 8 - 197 Aligned: 185 Modelled: 190 Confidence: 85.7% Identity: 16% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 2zd1 chain B domain 1 Region: 20 - 152 Aligned: 106 Modelled: 116 Confidence: 84.7% Identity: 20% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Reverse transcriptase Phyre2 PDB 3n6m chain A Region: 3 - 197 Aligned: 191 Modelled: 195 Confidence: 81.4% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:rna-dependent rna polymerase; PDBTitle: crystal structure of ev71 rdrp in complex with gtp Phyre2 PDB 2uut chain A Region: 11 - 162 Aligned: 147 Modelled: 152 Confidence: 80.7% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:rna-directed rna polymerase; PDBTitle: the 2.4 angstrom resolution structure of the d346g mutant2 of the sapporo virus rdrp polymerase Phyre2 PDB 3nah chain C Region: 8 - 197 Aligned: 185 Modelled: 190 Confidence: 78.1% Identity: 16% PDB header:transferase Chain: C: PDB Molecule:rna dependent rna polymerase; PDBTitle: crystal structures and functional analysis of murine norovirus rna-2 dependent rna polymerase Phyre2 PDB 3kk1 chain B Region: 29 - 152 Aligned: 98 Modelled: 107 Confidence: 77.6% Identity: 19% PDB header:transferase/dna Chain: B: PDB Molecule:reverse transcriptase p51 subunit; PDBTitle: hiv-1 reverse transcriptase-dna complex with nuceotide inhibitor gs-2 9148-diphosphate bound in nucleotide site Phyre2 PDB 1khv chain A Region: 12 - 162 Aligned: 145 Modelled: 151 Confidence: 75.1% Identity: 14% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 1ra6 chain A Region: 18 - 162 Aligned: 137 Modelled: 145 Confidence: 70.2% Identity: 15% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 5ovn chain A Region: 44 - 153 Aligned: 81 Modelled: 92 Confidence: 65.4% Identity: 26% PDB header:viral protein Chain: A: PDB Molecule:pol protein; PDBTitle: crystal strucure of fiv reverse transcriptase Phyre2 PDB 2b43 chain D Region: 17 - 197 Aligned: 174 Modelled: 181 Confidence: 65.3% Identity: 16% PDB header:viral protein Chain: D: PDB Molecule:non-structural polyprotein; PDBTitle: crystal structure of the norwalk virus rna dependent rna polymerase2 from strain hu/nlv/dresden174/1997/ge Phyre2 1 c6ar3A_ 2 c5g2xC_ 3 c5hhlA_ 4 c3du6A_ 5 c6d6vA_ 6 d1xr7a_ 7 d1u09a_ 8 c4nz0F_ 9 d1xr6a_ 10 c1rthA_ 11 d1sh0a_ 12 d2zd1b1 13 c3n6mA_ 14 c2uutA_ 15 c3nahC_ 16 c3kk1B_ 17 d1khva_ 18 d1ra6a_ 19 c5ovnA_ 20 c2b43D_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75