1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	D	L	S	I	S	Q	V	S	A	R	P	G	R	I	G	I	R	A	R	Q	M	F	D	G	Y	R	F	Q	R	G	P	V	L	V	V	V	E	D	G	R	I	S	A	V	D	F	A	G	S	A	C	P	D	M	N	L	V	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	G	E	S	T	L	L	P	G	L	V	D	A	H	A	H	L	C	W	D	P	D	G	R	P	E	D	L	A	G	D	P	H	A	V	L	V	G	R	A	R	R	H	A	A	A	A	L	R	S	G	I	T	T	I	R	D	L	G	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	D	Y	A	A	L	A	L	R	E	E	Y	R	Q	K	T	T	V	G	P	E	L	V	V	S	G	P	P	L	T	R	S	G	G	H	C	W	F	L	G	G	V	A	D	S	V	E	E	L	V	D	A	V	Q	E	R	A	A	R	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	D	W	I	K	V	M	A	T	G	G	F	V	T	T	A	S	D	P	W	Q	P	Q	Y	G	S	G	Q	L	A	A	V	V	A	A	A	E	Q	V	G	L	P	V	T	A	H	A	H	A	T	A	G	I	A	A	A	V	A	A	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	D	G	I	E	H	C	T	F	L	S	E	G	S	A	A	A	S	P	D	V	V	E	A	I	V	A	Q	G	V	W	C	G	M	T	I	P	R	V	Y	P	E	M	P	E	N	L	V	A	V	V	Q	D	G	W	R	N	I	R	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	I	D	A	G	A	R	V	A	L	S	T	D	A	G	V	A	P	G	R	R	H	D	V	L	P	D	D	L	V	Y	L	S	R	H	G	F	T	S	T	E	V	L	T	G	A	T	A	A	A	A	A	S	C	G	L	G	H	R	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.
Sequence		G	R	I	A	P	G	Y	D	A	D	L	L	A	V	A	A	G	V	D	H	D	P	A	G	L	C	D	V	K	A	V	W	R	S	G	T	Q	V	P	L	Q	A	S	A	V	G	Y	N	T	P	S
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 36%) Beta strand ( 19%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 4wgx chain D Region: 13 - 406 Aligned: 392 Modelled: 394 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: D: PDB Molecule:molinate hydrolase; PDBTitle: crystal structure of molinate hydrolase Phyre2 PDB 3be7 chain B Region: 14 - 401 Aligned: 374 Modelled: 387 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:zn-dependent arginine carboxypeptidase; PDBTitle: crystal structure of zn-dependent arginine carboxypeptidase Phyre2 PDB 3gnh chain A Region: 16 - 399 Aligned: 373 Modelled: 384 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:l-lysine, l-arginine carboxypeptidase cc2672; PDBTitle: crystal structure of l-lysine, l-arginine carboxypeptidase cc2672 from2 caulobacter crescentus cb15 complexed with n-methyl phosphonate3 derivative of l-arginine. Phyre2 PDB 4c65 chain A Region: 11 - 402 Aligned: 378 Modelled: 392 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:ochratoxinase; PDBTitle: crystal structure of a. niger ochratoxinase Phyre2 PDB 4whb chain C Region: 14 - 405 Aligned: 390 Modelled: 392 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: C: PDB Molecule:phenylurea hydrolase b; PDBTitle: crystal structure of phenylurea hydrolase b Phyre2 PDB 2qs8 chain A Region: 14 - 401 Aligned: 377 Modelled: 385 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:xaa-pro dipeptidase; PDBTitle: crystal structure of a xaa-pro dipeptidase with bound methionine in2 the active site Phyre2 PDB 2r8c chain B Region: 14 - 401 Aligned: 371 Modelled: 385 Confidence: 100.0% Identity: 30% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative amidohydrolase; PDBTitle: crystal structure of uncharacterized protein eaj56179 Phyre2 PDB 3feq chain B Region: 14 - 401 Aligned: 373 Modelled: 388 Confidence: 100.0% Identity: 27% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative amidohydrolase; PDBTitle: crystal structure of uncharacterized protein eah89906 Phyre2 PDB 4v1x chain A Region: 14 - 408 Aligned: 382 Modelled: 386 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:atrazine chlorohydrolase; PDBTitle: the structure of the hexameric atrazine chlorohydrolase, atza Phyre2 PDB 2p9b chain A Region: 13 - 408 Aligned: 377 Modelled: 380 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:possible prolidase; PDBTitle: crystal structure of putative prolidase from2 bifidobacterium longum Phyre2 PDB 4dyk chain B Region: 13 - 408 Aligned: 368 Modelled: 374 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an adenosine deaminase from pseudomonas2 aeruginosa pao1 (target nysgrc-200449) with bound zn Phyre2 PDB 2paj chain A Region: 15 - 408 Aligned: 373 Modelled: 380 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:putative cytosine/guanine deaminase; PDBTitle: crystal structure of an amidohydrolase from an environmental sample of2 sargasso sea Phyre2 PDB 4dzh chain A Region: 12 - 409 Aligned: 370 Modelled: 376 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an adenosine deaminase from xanthomonas2 campestris (target nysgrc-200456) with bound zn Phyre2 PDB 3hpa chain B Region: 14 - 408 Aligned: 367 Modelled: 368 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:amidohydrolase; PDBTitle: crystal structure of an amidohydrolase gi:44264246 from an2 evironmental sample of sargasso sea Phyre2 PDB 3lsb chain A Region: 15 - 408 Aligned: 381 Modelled: 385 Confidence: 100.0% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:triazine hydrolase; PDBTitle: crystal structure of the mutant e241q of atrazine chlorohydrolase trzn2 from arthrobacter aurescens tc1 complexed with zinc and ametrin Phyre2 PDB 3lnp chain A Region: 14 - 409 Aligned: 373 Modelled: 382 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase family protein olei01672_1_465; PDBTitle: crystal structure of amidohydrolase family protein olei01672_1_4652 from oleispira antarctica Phyre2 PDB 2q09 chain A Region: 14 - 399 Aligned: 367 Modelled: 382 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of imidazolonepropionase from environmental sample2 with bound inhibitor 3-(2,5-dioxo-imidazolidin-4-yl)-propionic acid Phyre2 PDB 3nqb chain B Region: 8 - 411 Aligned: 351 Modelled: 388 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:adenine deaminase 2; PDBTitle: crystal structure of adenine deaminase from agrobacterium tumefaciens2 (str. c 58) Phyre2 PDB 2gok chain A Region: 14 - 398 Aligned: 366 Modelled: 385 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: crystal structure of the imidazolonepropionase from agrobacterium2 tumefaciens at 1.87 a resolution Phyre2 PDB 2bb0 chain A Region: 12 - 401 Aligned: 368 Modelled: 389 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:imidazolonepropionase; PDBTitle: structure of imidazolonepropionase from bacillus subtilis Phyre2 1 c4wgxD_ 2 c3be7B_ 3 c3gnhA_ 4 c4c65A_ 5 c4whbC_ 6 c2qs8A_ 7 c2r8cB_ 8 c3feqB_ 9 c4v1xA_ 10 c2p9bA_ 11 c4dykB_ 12 c2pajA_ 13 c4dzhA_ 14 c3hpaB_ 15 c3lsbA_ 16 c3lnpA_ 17 c2q09A_ 18 c3nqbB_ 19 c2gokA_ 20 c2bb0A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226