1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	A	V	E	S	T	L	R	R	V	A	K	D	L	T	G	L	R	Q	R	W	A	L	V	G	G	F	A	V	S	A	R	S	E	P	R	F	T	R	D	V	D	I	V	V	A	V	A	N	D	D	A	A	E	S	L	V	R	Q
Secondary structure
SS confidence
Disorder		?	?	?	?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	T	Q	Q	Y	H	L	L	A	S	V	E	Q	D	A	A	R	R	L	A	A	V	R	L	G	A	T	A	D	T	A	A	N	V	V	V	D	L	L	F	A	S	C	G	I	E	P	E	I	A	E	A	A	E	E	I	E	I	L
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?																			?	?	?	?										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	D	L	V	A	P	V	A	T	T	A	H	L	I	A	M	K	L	L	A	R	D	D	D	R	R	P	Q	D	R	S	D	L	R	A	L	V	D	A	A	S	P	Q	D	I	Q	D	A	R	K	A	I	E	L	I	T	L	R	G	F
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?	?											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.
Sequence		H	R	D	R	D	L	A	A	E	W	T	R	L	A	A	K	W
Secondary structure
SS confidence
Disorder															?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 53%) Beta strand ( 16%)

Rank Aligned region

PDB 5uvd chain A Region: 2 - 183 Aligned: 182 Modelled: 182 Confidence: 99.8% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:nucleotidyltransferase-like protein; PDBTitle: crystal structure of an antigenic nucleotidyltransferase-like protein2 from paracoccidioides brasiliensis Phyre2 PDB 4e8i chain A Region: 5 - 158 Aligned: 149 Modelled: 154 Confidence: 99.7% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:lincosamide resistance protein; PDBTitle: crystal structure of lincosamide antibiotic adenylyltransferase lina,2 apo Phyre2 PDB 4wqk chain A Region: 5 - 174 Aligned: 155 Modelled: 155 Confidence: 99.5% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:2''-aminoglycoside nucleotidyltransferase; PDBTitle: crystal structure of aminoglycoside nucleotidylyltransferase ant(2")-2 ia, apo form Phyre2 PDB 4ok0 chain B Region: 1 - 173 Aligned: 164 Modelled: 173 Confidence: 99.5% Identity: 15% PDB header:transferase Chain: B: PDB Molecule:putative; PDBTitle: crystal structure of putative nucleotidyltransferase from h. pylori Phyre2 PDB 2fcl chain A domain 1 Region: 10 - 132 Aligned: 109 Modelled: 120 Confidence: 97.5% Identity: 16% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: TM1012-like Phyre2 PDB 3h37 chain B Region: 2 - 59 Aligned: 57 Modelled: 58 Confidence: 94.0% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:trna nucleotidyl transferase-related protein; PDBTitle: the structure of cca-adding enzyme apo form i Phyre2 PDB 1ou5 chain A domain 2 Region: 2 - 57 Aligned: 55 Modelled: 56 Confidence: 93.9% Identity: 11% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Poly A polymerase head domain-like Phyre2 PDB 1sz1 chain A Region: 2 - 116 Aligned: 106 Modelled: 113 Confidence: 93.7% Identity: 16% PDB header:transferase/rna Chain: A: PDB Molecule:trna nucleotidyltransferase; PDBTitle: mechanism of cca-adding enzymes specificity revealed by crystal2 structures of ternary complexes Phyre2 PDB 6q52 chain A Region: 2 - 56 Aligned: 54 Modelled: 55 Confidence: 93.4% Identity: 17% PDB header:rna binding protein Chain: A: PDB Molecule:cca-adding enzyme; PDBTitle: structure of a psychrophilic cca-adding enzyme in complex with cmpcpp2 at room temperature in chipx microfluidic device Phyre2 PDB 1miw chain A domain 2 Region: 3 - 56 Aligned: 52 Modelled: 53 Confidence: 93.3% Identity: 21% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Poly A polymerase head domain-like Phyre2 PDB 1miy chain B Region: 1 - 57 Aligned: 56 Modelled: 57 Confidence: 92.9% Identity: 20% PDB header:translation, transferase Chain: B: PDB Molecule:trna cca-adding enzyme; PDBTitle: crystal structure of bacillus stearothermophilus cca-adding enzyme in2 complex with ctp Phyre2 PDB 4x4w chain B Region: 8 - 60 Aligned: 52 Modelled: 53 Confidence: 92.8% Identity: 12% PDB header:rna binding protein Chain: B: PDB Molecule:cca trna nucleotidyltransferase 1, mitochondrial; PDBTitle: crystal structure of the full-length human mitochondrial cca-adding2 enzyme Phyre2 PDB 1vfg chain A domain 2 Region: 11 - 62 Aligned: 51 Modelled: 52 Confidence: 92.4% Identity: 25% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Poly A polymerase head domain-like Phyre2 PDB 1ou5 chain A Region: 8 - 57 Aligned: 49 Modelled: 50 Confidence: 89.3% Identity: 12% PDB header:translation, transferase Chain: A: PDB Molecule:trna cca-adding enzyme; PDBTitle: crystal structure of human cca-adding enzyme Phyre2 PDB 3wfr chain H Region: 1 - 62 Aligned: 62 Modelled: 62 Confidence: 89.3% Identity: 21% PDB header:transferase/rna Chain: H: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme complex 2 Phyre2 PDB 3wfp chain B Region: 1 - 66 Aligned: 66 Modelled: 66 Confidence: 88.1% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme (apo form 2) Phyre2 PDB 3wfr chain G Region: 1 - 62 Aligned: 62 Modelled: 62 Confidence: 86.2% Identity: 21% PDB header:transferase/rna Chain: G: PDB Molecule:poly a polymerase; PDBTitle: trna processing enzyme complex 2 Phyre2 PDB 1wot chain A Region: 2 - 84 Aligned: 80 Modelled: 83 Confidence: 85.1% Identity: 16% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Catalytic subunit of bi-partite nucleotidyltransferase Phyre2 PDB 1vfg chain B Region: 11 - 70 Aligned: 59 Modelled: 60 Confidence: 84.2% Identity: 22% PDB header:transferase/rna Chain: B: PDB Molecule:poly a polymerase; PDBTitle: crystal structure of trna nucleotidyltransferase complexed2 with a primer trna and an incoming atp analog Phyre2 PDB 1r89 chain A domain 2 Region: 2 - 116 Aligned: 107 Modelled: 108 Confidence: 83.2% Identity: 17% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Archaeal tRNA CCA-adding enzyme catalytic domain Phyre2 1 c5uvdA_ 2 c4e8iA_ 3 c4wqkA_ 4 c4ok0B_ 5 d2fcla1 6 c3h37B_ 7 d1ou5a2 8 c1sz1A_ 9 c6q52A_ 10 d1miwa2 11 c1miyB_ 12 c4x4wB_ 13 d1vfga2 14 c1ou5A_ 15 c3wfrH_ 16 c3wfpB_ 17 c3wfrG_ 18 d1wota_ 19 c1vfgB_ 20 d1r89a2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77