1

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10

.

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20

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30

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40

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50

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.

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60

Sequence

V

A

V

S

V

A

A

Q

K

L

R

L

A

L

D

M

Y

E

V

G

E

Q

M

Q

R

M

R

L

G

R

E

R

P

N

A

D

V

V

E

I

E

A

A

I

D

A

W

R

M

T

R

P

G

A

E

E

G

D

S

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

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Sequence

G

P

T

S

T

R

F

T

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 44%) Alpha helix ( 51%) Beta strand ( 10%)

Rank Aligned region

PDB 5mz6 chain B Region: 24 - 62 Aligned: 38 Modelled: 39 Confidence: 19.6% Identity: 37% PDB header:cell cycle Chain: B: PDB Molecule:interactor of fizzy protein; PDBTitle: cryo-em structure of a separase-securin complex from caenorhabditis2 elegans at 3.8 a resolution Phyre2 PDB 2f9j chain P Region: 21 - 31 Aligned: 11 Modelled: 11 Confidence: 18.0% Identity: 55% PDB header:rna binding protein Chain: P: PDB Molecule:splicing factor 3b subunit 1; PDBTitle: 3.0 angstrom resolution structure of a y22m mutant of the spliceosomal2 protein p14 bound to a region of sf3b155 Phyre2 PDB 2dk8 chain A domain 1 Region: 33 - 44 Aligned: 12 Modelled: 12 Confidence: 16.8% Identity: 67% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: RPO3F domain-like Phyre2 PDB 3bmz chain A Region: 26 - 53 Aligned: 28 Modelled: 28 Confidence: 16.5% Identity: 32% PDB header:biosynthetic protein Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: violacein biosynthetic enzyme vioe Phyre2 PDB 3kev chain A Region: 27 - 49 Aligned: 22 Modelled: 23 Confidence: 14.4% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:galieria sulfuraria dcun1 domain-containing protein; PDBTitle: x-ray crystal structure of a dcun1 domain-containing protein from2 galdieria sulfuraria Phyre2 PDB 6gu1 chain B Region: 15 - 29 Aligned: 15 Modelled: 15 Confidence: 13.9% Identity: 47% PDB header:unknown function Chain: B: PDB Molecule:secreted rxlr effector peptide protein, putative; PDBTitle: sfi3 effector protein from the oomycete plant pathogen phytophthora2 infestans Phyre2 PDB 5ewn chain A Region: 45 - 68 Aligned: 24 Modelled: 24 Confidence: 13.0% Identity: 29% PDB header:viral protein Chain: A: PDB Molecule:structural protein; PDBTitle: crystal structure of the human astrovirus 1 capsid protein core domain2 at 2.6 a resolution Phyre2 PDB 3b1s chain C Region: 22 - 38 Aligned: 17 Modelled: 17 Confidence: 12.0% Identity: 35% PDB header:protein transport Chain: C: PDB Molecule:flagellar biosynthetic protein flhb; PDBTitle: crystal structure of the cytoplasmic domain of flhb from aquifex2 aeolicus Phyre2 PDB 2hg6 chain A domain 1 Region: 24 - 32 Aligned: 9 Modelled: 9 Confidence: 11.7% Identity: 67% Fold: PA1123-like Superfamily: PA1123-like Family: PA1123-like Phyre2 PDB 3b1s chain A Region: 22 - 38 Aligned: 17 Modelled: 17 Confidence: 11.4% Identity: 35% PDB header:protein transport Chain: A: PDB Molecule:flagellar biosynthetic protein flhb; PDBTitle: crystal structure of the cytoplasmic domain of flhb from aquifex2 aeolicus Phyre2 PDB 3b1s chain E Region: 22 - 38 Aligned: 17 Modelled: 17 Confidence: 10.9% Identity: 35% PDB header:protein transport Chain: E: PDB Molecule:flagellar biosynthetic protein flhb; PDBTitle: crystal structure of the cytoplasmic domain of flhb from aquifex2 aeolicus Phyre2 PDB 5v89 chain A Region: 27 - 49 Aligned: 22 Modelled: 23 Confidence: 10.8% Identity: 18% PDB header:ligase / protein binding Chain: A: PDB Molecule:dcn1-like protein 4; PDBTitle: structure of dcn4 pony domain bound to cul1 whb Phyre2 PDB 3bq3 chain A Region: 27 - 53 Aligned: 26 Modelled: 27 Confidence: 9.9% Identity: 19% PDB header:cell cycle, ligase Chain: A: PDB Molecule:defective in cullin neddylation protein 1; PDBTitle: crystal structure of s. cerevisiae dcn1 Phyre2 PDB 4gao chain A Region: 27 - 53 Aligned: 26 Modelled: 27 Confidence: 9.5% Identity: 19% PDB header:ligase/peptide Chain: A: PDB Molecule:dcn1-like protein 2; PDBTitle: dcnl complex with n-terminally acetylated nedd8 e2 peptide Phyre2 PDB 6g90 chain Q Region: 8 - 61 Aligned: 46 Modelled: 54 Confidence: 9.0% Identity: 24% PDB header:splicing Chain: Q: PDB Molecule:cold sensitive u2 snrna suppressor 1; PDBTitle: prespliceosome structure provides insight into spliceosome assembly2 and regulation (map a2) Phyre2 PDB 2z5h chain T Region: 30 - 56 Aligned: 27 Modelled: 27 Confidence: 8.1% Identity: 37% PDB header:contractile protein Chain: T: PDB Molecule:troponin t, fast skeletal muscle isoforms; PDBTitle: crystal structure of the head-to-tail junction of tropomyosin2 complexed with a fragment of tnt Phyre2 PDB 5gne chain A Region: 27 - 54 Aligned: 27 Modelled: 28 Confidence: 7.5% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:leucine aminopeptidase; PDBTitle: crystal structure of lapb from legionella pneumophila Phyre2 PDB 1s4k chain A Region: 17 - 32 Aligned: 16 Modelled: 16 Confidence: 7.1% Identity: 19% Fold: lambda repressor-like DNA-binding domains Superfamily: lambda repressor-like DNA-binding domains Family: YdiL-like Phyre2 PDB 3gli chain O Region: 44 - 58 Aligned: 15 Modelled: 15 Confidence: 6.6% Identity: 47% PDB header:transferase/dna Chain: O: PDB Molecule:dna polymerase iii subunit psi; PDBTitle: crystal structure of the e. coli clamp loader bound to primer-template2 dna and psi peptide Phyre2 PDB 2is9 chain A Region: 27 - 53 Aligned: 26 Modelled: 27 Confidence: 6.6% Identity: 19% PDB header:transcription Chain: A: PDB Molecule:defective in cullin neddylation protein 1; PDBTitle: structure of yeast dcn-1 Phyre2 1 c5mz6B_ 2 c2f9jP_ 3 d2dk8a1 4 c3bmzA_ 5 c3kevA_ 6 c6gu1B_ 7 c5ewnA_ 8 c3b1sC_ 9 d2hg6a1 10 c3b1sA_ 11 c3b1sE_ 12 c5v89A_ 13 c3bq3A_ 14 c4gaoA_ 15 c6g90Q_ 16 c2z5hT_ 17 c5gneA_ 18 d1s4ka_ 19 c3gliO_ 20 c2is9A_ 21 22 23 24 25 26 27 28