1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	V	T	V	G	V	I	C	A	I	P	Q	E	L	A	Y	L	R	G	V	L	V	D	A	K	R	Q	Q	V	A	Q	I	L	F	D	S	G	Q	L	D	A	H	R	V	V	L	A	A	A	G	M	G	K	V	N	T	G	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?																							?	?	?																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	T	L	L	A	D	R	F	G	C	R	T	I	V	F	T	G	V	A	G	G	L	D	P	E	L	C	I	G	D	I	V	I	A	D	R	V	V	Q	H	D	F	G	L	L	T	D	E	R	L	R	P	Y	Q	P	G	H	I	P	F
Secondary structure
SS confidence
Disorder																																																		?	?	?	?					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	E	P	T	E	R	L	G	Y	P	V	D	P	A	V	I	D	R	V	K	H	R	L	D	G	F	T	L	A	P	L	S	T	A	A	G	G	G	G	R	Q	P	R	I	Y	Y	G	T	I	L	T	G	D	Q	Y	L	H	C	E	R
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	R	N	R	L	H	H	E	L	G	G	M	A	V	E	M	E	G	G	A	V	A	Q	I	C	A	S	F	D	I	P	W	L	V	I	R	A	L	S	D	L	A	G	A	D	S	G	V	D	F	N	R	F	V	G	E	V	A	A	S
Secondary structure
SS confidence
Disorder																																														?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.
Sequence		S	A	R	V	L	L	R	L	L	P	V	L	T	A	C
Secondary structure
SS confidence
Disorder											?		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 35%) Beta strand ( 27%)

Rank Aligned region

PDB 6ayt chain D Region: 2 - 252 Aligned: 229 Modelled: 237 Confidence: 100.0% Identity: 29% PDB header:hydrolase, transferase Chain: D: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of campylobacter jejuni 5'-methylthioadenosine/s-2 adenosyl homocysteine nucleosidase (mtan) complexed with3 pyrazinylthio-dadme-immucillin-a Phyre2 PDB 4jwt chain A Region: 2 - 254 Aligned: 231 Modelled: 237 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:methylthioadenosine nucleosidase; PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from sulfurimonas denitrificans dsm3 1251 (target nysgrc-029304 ) Phyre2 PDB 1zos chain E Region: 3 - 252 Aligned: 228 Modelled: 236 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: E: PDB Molecule:5'-methylthioadenosine / s-adenosylhomocysteine PDBTitle: structure of 5'-methylthionadenosine/s-adenosylhomocysteine2 nucleosidase from s. pneumoniae with a transition-state inhibitor mt-3 imma Phyre2 PDB 4kn5 chain A Region: 2 - 250 Aligned: 228 Modelled: 247 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:methylthioadenosine nucleosidase; PDBTitle: crystal structure of a putative methylthioadenosine nucleosidase from2 weissella paramesenteroides atcc 33313 (target nysgrc-029342 ) Phyre2 PDB 5dk6 chain A Region: 4 - 254 Aligned: 231 Modelled: 251 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of a 5'-methylthioadenosine/s-adenosylhomocysteine2 (mta/sah) nucleosidase (mtan) from colwellia psychrerythraea 34h3 (cps_4743, target psi-029300) in complex with adenine at 2.27 a4 resolution Phyre2 PDB 6po4 chain A Region: 2 - 254 Aligned: 231 Modelled: 231 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: 2.1 angstrom resolution crystal structure of 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase (mtnn) from haemophilus influenzae3 pittii. Phyre2 PDB 3dp9 chain A Region: 4 - 252 Aligned: 228 Modelled: 249 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:mta/sah nucleosidase; PDBTitle: crystal structure of vibrio cholerae 5'-methylthioadenosine/s-adenosyl2 homocysteine nucleosidase (mtan) complexed with butylthio-dadme-3 immucillin a Phyre2 PDB 3eei chain A Region: 1 - 252 Aligned: 230 Modelled: 248 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:5-methylthioadenosine nucleosidase/s-adenosylhomocysteine PDBTitle: crystal structure of 5'-methylthioadenosine/s-adenosylhomocysteine2 nucleosidase from neisseria meningitidis in complex with methylthio-3 immucillin-a Phyre2 PDB 3bl6 chain A Region: 2 - 252 Aligned: 229 Modelled: 237 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase/s- PDBTitle: crystal structure of staphylococcus aureus 5'-2 methylthioadenosine/s-adenosylhomocysteine nucleosidase in3 complex with formycin a Phyre2 PDB 4g41 chain A Region: 2 - 252 Aligned: 229 Modelled: 237 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:mta/sah nucleosidase; PDBTitle: crystal structure of s-adenosylhomocysteine nucleosidase from2 streptococcus pyogenes in complex with 5-methylthiotubericidin Phyre2 PDB 3nm5 chain B Region: 4 - 252 Aligned: 227 Modelled: 235 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:mta/sah nucleosidase; PDBTitle: helicobacter pylori mtan complexed with formycin a Phyre2 PDB 4jos chain A Region: 4 - 252 Aligned: 226 Modelled: 234 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from francisella philomiragia atcc3 25017 (target nysgrc-029335) Phyre2 PDB 4qez chain C Region: 4 - 254 Aligned: 225 Modelled: 225 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: C: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: crystal structure of 5'-methylthioadenosine/s-adenosylhomocysteine2 nucleosidase from bacillus anthracis Phyre2 PDB 4l0m chain A Region: 4 - 252 Aligned: 229 Modelled: 244 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:putative 5'-methylthioadenosine/s-adenosylhomocysteine PDBTitle: crystal structure of a putative 5'-methylthioadenosine/s-2 adenosylhomocysteine nucleosidase from borrelia burgdorferi b31 bound3 to adenine (target nysgrc-029268 ) Phyre2 PDB 6if8 chain D Region: 3 - 252 Aligned: 220 Modelled: 228 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: D: PDB Molecule:5'-methylthioadenosine/s-adenosylhomocysteine nucleosidase; PDBTitle: aeromonas hydrophila mtan-2 complexed with adenine Phyre2 PDB 1jys chain A Region: 3 - 252 Aligned: 224 Modelled: 236 Confidence: 100.0% Identity: 32% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 5b7p chain B Region: 2 - 253 Aligned: 233 Modelled: 252 Confidence: 100.0% Identity: 24% PDB header:hydrolase Chain: B: PDB Molecule:mta/sah nucleosidase; PDBTitle: structures and functional analysis of periplasmic 5-2 methylthioadenosine/s-adenosylhomocysteine nucleosidase from3 aeromonas hydrophila Phyre2 PDB 2h8g chain A Region: 1 - 254 Aligned: 220 Modelled: 221 Confidence: 100.0% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:5'-methylthioadenosine nucleosidase; PDBTitle: 5'-methylthioadenosine nucleosidase from arabidopsis2 thaliana Phyre2 PDB 3bsf chain B Region: 3 - 252 Aligned: 216 Modelled: 217 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:at4g34840; PDBTitle: crystal structure of the mta/sah nucleosidase Phyre2 PDB 1rxy chain A Region: 1 - 252 Aligned: 221 Modelled: 238 Confidence: 100.0% Identity: 16% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 1 c6aytD_ 2 c4jwtA_ 3 c1zosE_ 4 c4kn5A_ 5 c5dk6A_ 6 c6po4A_ 7 c3dp9A_ 8 c3eeiA_ 9 c3bl6A_ 10 c4g41A_ 11 c3nm5B_ 12 c4josA_ 13 c4qezC_ 14 c4l0mA_ 15 c6if8D_ 16 d1jysa_ 17 c5b7pB_ 18 c2h8gA_ 19 c3bsfB_ 20 d1rxya_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99