1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	T	F	E	S	V	A	D	L	A	A	A	A	G	E	K	V	G	Q	S	D	W	V	T	I	T	Q	E	E	V	N	L	F	A	D	A	T	G	D	H	Q	W	I	H	V	D	P	E	R	A	A	A	G	P	F	G	T	T	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	H	G	F	M	T	L	A	L	L	P	R	L	Q	H	Q	M	Y	T	V	K	G	V	K	L	A	I	N	Y	G	L	N	K	V	R	F	P	A	P	V	P	V	G	S	R	V	R	A	T	S	S	L	V	G	V	E	D	L	G	N
Secondary structure
SS confidence
Disorder																																																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Sequence		G	T	V	Q	A	T	V	S	T	T	V	E	V	E	G	S	A	K	P	A	C	V	A	E	S	I	V	R	Y	V	A
Secondary structure
SS confidence
Disorder																												?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 26%) Beta strand ( 40%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 2c2i chain A domain 1 Region: 2 - 150 Aligned: 149 Modelled: 149 Confidence: 100.0% Identity: 99% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 4e3e chain A Region: 2 - 149 Aligned: 143 Modelled: 146 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc domain protein dehydratase; PDBTitle: crystal structure of putative maoc domain protein dehydratase from2 chloroflexus aurantiacus j-10-fl Phyre2 PDB 2bi0 chain A domain 1 Region: 5 - 148 Aligned: 138 Modelled: 141 Confidence: 100.0% Identity: 14% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 2bi0 chain A Region: 5 - 149 Aligned: 139 Modelled: 141 Confidence: 100.0% Identity: 14% PDB header:hypothetical protein Chain: A: PDB Molecule:hypothetical protein rv0216; PDBTitle: rv0216, a conserved hypothetical protein from mycobacterium2 tuberculosis that is essential for bacterial survival3 during infection, has a double hotdogfold Phyre2 PDB 4ffu chain A Region: 5 - 149 Aligned: 138 Modelled: 145 Confidence: 100.0% Identity: 26% PDB header:oxidoreductase Chain: A: PDB Molecule:oxidase; PDBTitle: crystal structure of putative maoc-like (monoamine oxidase-like)2 protein, similar to nodn from sinorhizo bium meliloti 1021 Phyre2 PDB 1q6w chain A Region: 2 - 149 Aligned: 144 Modelled: 148 Confidence: 100.0% Identity: 24% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 3exz chain A Region: 5 - 149 Aligned: 139 Modelled: 143 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:maoc-like dehydratase; PDBTitle: crystal structure of the maoc-like dehydratase from rhodospirillum2 rubrum. northeast structural genomics consortium target rrr103a. Phyre2 PDB 2b3n chain A domain 1 Region: 2 - 148 Aligned: 130 Modelled: 138 Confidence: 99.9% Identity: 22% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 5cpg chain A Region: 5 - 149 Aligned: 132 Modelled: 143 Confidence: 99.9% Identity: 24% PDB header:lyase Chain: A: PDB Molecule:(r)-specific enoyl-coa hydratase; PDBTitle: r-hydratase phaj1 from pseudomonas aeruginosa in the unliganded form Phyre2 PDB 1iq6 chain A Region: 8 - 149 Aligned: 130 Modelled: 142 Confidence: 99.9% Identity: 28% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 4w7b chain G Region: 7 - 149 Aligned: 142 Modelled: 143 Confidence: 99.9% Identity: 17% PDB header:lyase Chain: G: PDB Molecule:hydratase chsh1; PDBTitle: crystal structure of the chsh1:chsh2: complex from mycobacterium2 tuberculosis Phyre2 PDB 2bi0 chain A domain 2 Region: 2 - 151 Aligned: 136 Modelled: 150 Confidence: 99.9% Identity: 18% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 PDB 5zy8 chain A Region: 13 - 147 Aligned: 128 Modelled: 135 Confidence: 99.9% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:upf0336 protein rv0637; PDBTitle: crystal structure of c terminal truncated hadbc (3r-hydroxyacyl-acp2 dehydratase) complex from mycobacterium tuberculosis Phyre2 PDB 4rlt chain A Region: 13 - 149 Aligned: 135 Modelled: 137 Confidence: 99.9% Identity: 11% PDB header:lyase/lyase inhibitor Chain: A: PDB Molecule:(3r)-hydroxyacyl-acp dehydratase subunit hada; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium tuberculosis complexed with fisetin Phyre2 PDB 4rv2 chain A Region: 13 - 147 Aligned: 130 Modelled: 135 Confidence: 99.9% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:upf0336 protein msmeg_1340/msmei_1302; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium smegmatis Phyre2 PDB 4w7b chain D Region: 13 - 147 Aligned: 122 Modelled: 135 Confidence: 99.9% Identity: 16% PDB header:lyase Chain: D: PDB Molecule:hydratase chsh2; PDBTitle: crystal structure of the chsh1:chsh2: complex from mycobacterium2 tuberculosis Phyre2 PDB 4v12 chain A Region: 8 - 149 Aligned: 140 Modelled: 142 Confidence: 99.9% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:maoc like domain protein; PDBTitle: crystal structure of the msmeg_6754 dehydratase from mycobacterium2 smegmatis Phyre2 PDB 4rv2 chain B Region: 3 - 148 Aligned: 138 Modelled: 146 Confidence: 99.9% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:maoc family protein; PDBTitle: crystal structure of (3r)-hydroxyacyl-acp dehydratase hadab hetero-2 dimer from mycobacterium smegmatis Phyre2 PDB 3ir3 chain B Region: 14 - 148 Aligned: 112 Modelled: 135 Confidence: 99.9% Identity: 25% PDB header:lyase Chain: B: PDB Molecule:3-hydroxyacyl-thioester dehydratase 2; PDBTitle: crystal structure of human 3-hydroxyacyl-thioester dehydratase 22 (htd2) Phyre2 PDB 1s9c chain A domain 1 Region: 14 - 146 Aligned: 120 Modelled: 133 Confidence: 99.8% Identity: 19% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: MaoC-like Phyre2 1 d2c2ia1 2 c4e3eA_ 3 d2bi0a1 4 c2bi0A_ 5 c4ffuA_ 6 d1q6wa_ 7 c3exzA_ 8 d2b3na1 9 c5cpgA_ 10 d1iq6a_ 11 c4w7bG_ 12 d2bi0a2 13 c5zy8A_ 14 c4rltA_ 15 c4rv2A_ 16 c4w7bD_ 17 c4v12A_ 18 c4rv2B_ 19 c3ir3B_ 20 d1s9ca1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165