1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	P	G	D	W	S	V	F	A	W	H	A	A	N	L	P	T	M	P	E	A	E	D	I	G	N	E	A	A	G	G	R	F	G	V	S	I	R	S	A	G	Y	L	R	K	W	F	L	L	G	I	T	I	G	V	I	A	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	A	V	V	F	Y	L	A	L	K	Y	T	S	E	F	L	L	G	Y	L	A	D	Y	Q	I	P	T	P	V	G	E	G	G	H	R	G	S	T	G	F	A	R	P	W	A	I	P	L	V	T	T	G	G	A	V	L	S	A	L	I
Secondary structure
SS confidence
Disorder																							?	?			?	?	?	?	?	?	?	?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	A	K	L	A	P	E	A	T	G	H	G	T	D	E	A	I	E	S	V	H	G	D	P	R	A	I	R	G	R	A	V	L	V	K	M	V	A	S	A	L	T	I	G	S	G	G	S	G	G	R	E	G	P	T	A	Q	I	S	A
Secondary structure
SS confidence
Disorder											?												?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	F	C	S	L	L	T	R	R	L	N	L	S	N	E	D	G	R	T	A	V	A	L	G	I	G	A	G	I	G	A	I	F	A	A	P	L	G	G	A	A	L	G	A	S	I	P	Y	R	D	D	F	D	Y	R	N	L	L	P	G
Secondary structure
SS confidence
Disorder																																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	I	A	S	G	T	A	Y	A	V	L	G	A	F	L	G	F	D	P	L	F	G	Y	I	D	A	E	Y	R	F	E	K	A	W	P	L	L	W	F	V	V	I	G	L	I	A	A	A	V	G	Y	L	Y	A	R	V	F	H	A	S
Secondary structure
SS confidence
Disorder																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	A	I	T	R	R	L	P	G	G	P	V	L	K	P	A	I	G	G	L	L	V	G	L	L	G	L	P	I	P	Q	I	L	S	S	G	Y	G	W	A	Q	L	A	A	D	R	G	T	L	L	S	I	P	L	W	I	V	I	V	L
Secondary structure
SS confidence
Disorder																																																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		P	I	A	K	I	L	A	T	S	L	S	I	G	T	G	G	S	G	G	L	F	G	P	G	I	V	I	G	A	F	V	G	A	A	I	W	R	L	G	E	L	T	E	L	P	G	V	P	H	E	P	G	I	F	V	V	V	A	M	M
Secondary structure
SS confidence
Disorder																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		A	C	F	G	S	V	S	R	A	P	L	A	V	M	I	M	V	A	E	M	T	G	S	F	S	V	V	P	G	A	I	I	A	V	G	I	A	A	L	L	L	S	R	T	N	V	T	I	Y	E	T	Q	R	L	N	R	Q	T	A	E
Secondary structure
SS confidence
Disorder																																																								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.
Sequence		A	E	R	G	G	S	D	R	P	T	T	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 39%) (View membrane topology prediction)

Rank Aligned region

PDB 1ots chain A Region: 29 - 484 Aligned: 437 Modelled: 456 Confidence: 100.0% Identity: 23% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 2ht2 chain B Region: 27 - 482 Aligned: 434 Modelled: 456 Confidence: 100.0% Identity: 23% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 PDB 1kpl chain A Region: 46 - 484 Aligned: 420 Modelled: 435 Confidence: 100.0% Identity: 25% Fold: Clc chloride channel Superfamily: Clc chloride channel Family: Clc chloride channel Phyre2 PDB 3nd0 chain A Region: 46 - 488 Aligned: 418 Modelled: 443 Confidence: 100.0% Identity: 23% PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter Phyre2 PDB 6coy chain B Region: 46 - 477 Aligned: 412 Modelled: 420 Confidence: 100.0% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:chloride channel protein 1; PDBTitle: human clc-1 chloride ion channel, transmembrane domain Phyre2 PDB 6qvc chain B Region: 46 - 491 Aligned: 429 Modelled: 446 Confidence: 100.0% Identity: 18% PDB header:membrane protein Chain: B: PDB Molecule:chloride channel protein 1; PDBTitle: cryoem structure of the human clc-1 chloride channel, cbs state 1 Phyre2 PDB 5tr1 chain A Region: 42 - 492 Aligned: 424 Modelled: 451 Confidence: 100.0% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:chloride channel protein; PDBTitle: cryo-electron microscopy structure of a bovine clc-k chloride channel,2 alternate (class 2) conformation Phyre2 PDB 3org chain B Region: 43 - 488 Aligned: 401 Modelled: 416 Confidence: 100.0% Identity: 22% PDB header:transport protein Chain: B: PDB Molecule:cmclc; PDBTitle: crystal structure of a eukaryotic clc transporter Phyre2 PDB 6d0n chain A Region: 43 - 473 Aligned: 386 Modelled: 408 Confidence: 100.0% Identity: 23% PDB header:transport protein Chain: A: PDB Molecule:clc-type fluoride/proton antiporter; PDBTitle: crystal structure of a clc-type fluoride/proton antiporter, v319g2 mutant Phyre2 PDB 3qe7 chain A Region: 181 - 325 Aligned: 131 Modelled: 140 Confidence: 24.4% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:uracil permease; PDBTitle: crystal structure of uracil transporter--uraa Phyre2 PDB 2inp chain E Region: 2 - 37 Aligned: 33 Modelled: 36 Confidence: 15.9% Identity: 15% PDB header:oxidoreductase Chain: E: PDB Molecule:phenol hydroxylase component pho; PDBTitle: structure of the phenol hydroxylase-regulatory protein2 complex Phyre2 PDB 5xyi chain E Region: 18 - 48 Aligned: 29 Modelled: 31 Confidence: 12.2% Identity: 10% PDB header:ribosome Chain: E: PDB Molecule:40s ribosomal protein s4; PDBTitle: small subunit of trichomonas vaginalis ribosome Phyre2 PDB 3m9h chain B Region: 468 - 488 Aligned: 21 Modelled: 21 Confidence: 10.9% Identity: 38% PDB header:chaperone Chain: B: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain of the2 mycobacterium tuberculosis proteasomal atpase mpa Phyre2 PDB 3d9s chain B Region: 96 - 146 Aligned: 50 Modelled: 51 Confidence: 10.4% Identity: 18% PDB header:membrane protein Chain: B: PDB Molecule:aquaporin-5; PDBTitle: human aquaporin 5 (aqp5) - high resolution x-ray structure Phyre2 PDB 2kjf chain A Region: 157 - 185 Aligned: 29 Modelled: 29 Confidence: 9.4% Identity: 24% PDB header:antimicrobial protein Chain: A: PDB Molecule:carnocyclin-a; PDBTitle: the solution structure of the circular bacteriocin2 carnocyclin a (ccla) Phyre2 PDB 6m97 chain A Region: 47 - 69 Aligned: 23 Modelled: 23 Confidence: 9.2% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:chimera protein of high affinity copper uptake protein 1 PDBTitle: crystal structure of the high-affinity copper transporter ctr1 Phyre2 PDB 2knc chain A Region: 277 - 311 Aligned: 35 Modelled: 35 Confidence: 9.1% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 5ceh chain A Region: 6 - 15 Aligned: 10 Modelled: 10 Confidence: 8.1% Identity: 40% PDB header:oxidoreductase/inhibitor Chain: A: PDB Molecule:lysine-specific demethylase 5a; PDBTitle: structure of histone lysine demethylase kdm5a in complex with2 selective inhibitor Phyre2 PDB 1j4n chain A Region: 48 - 137 Aligned: 70 Modelled: 70 Confidence: 7.8% Identity: 19% Fold: Aquaporin-like Superfamily: Aquaporin-like Family: Aquaporin-like Phyre2 PDB 2mgy chain A Region: 271 - 329 Aligned: 57 Modelled: 59 Confidence: 7.8% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:translocator protein; PDBTitle: solution structure of the mitochondrial translocator protein (tspo) in2 complex with its high-affinity ligand pk11195 Phyre2 1 d1otsa_ 2 c2ht2B_ 3 d1kpla_ 4 c3nd0A_ 5 c6coyB_ 6 c6qvcB_ 7 c5tr1A_ 8 c3orgB_ 9 c6d0nA_ 10 c3qe7A_ 11 c2inpE_ 12 c5xyie_ 13 c3m9hB_ 14 c3d9sB_ 15 c2kjfA_ 16 c6m97A_ 17 c2kncA_ 18 c5cehA_ 19 d1j4na_ 20 c2mgyA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39