1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	V	R	E	L	P	G	A	W	N	F	R	D	V	A	D	T	A	T	A	L	R	P	G	R	L	F	R	S	S	E	L	S	R	L	D	D	A	G	R	A	T	L	R	R	L	G	I	T	D	V	A	D	L	R	S	S	R	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	R	R	G	P	G	R	V	P	D	G	I	D	V	H	L	L	P	F	P	D	L	A	D	D	D	A	D	D	S	A	P	H	E	T	A	F	K	R	L	L	T	N	D	G	S	N	G	E	S	G	E	S	S	Q	S	I	N	D
Secondary structure
SS confidence
Disorder			?	?	?																				?	?	?	?	?	?	?	?	?												?	?	?	?	?	?	?	?						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	T	R	Y	M	T	D	E	Y	R	Q	F	P	T	R	N	G	A	Q	R	A	L	H	R	V	V	T	L	L	A	A	G	R	P	V	L	T	H	C	F	A	G	K	D	R	T	G	F	V	V	A	L	V	L	E	A	V	G	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	R	D	V	I	V	A	D	Y	L	R	S	N	D	S	V	P	Q	L	R	A	R	I	S	E	M	I	Q	Q	R	F	D	T	E	L	A	P	E	V	V	T	F	T	K	A	R	L	S	D	G	V	L	G	V	R	A	E	Y	L	A
Secondary structure
SS confidence
Disorder																														?	?	?	?										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.
Sequence		A	A	R	Q	T	I	D	E	T	Y	G	S	L	G	G	Y	L	R	D	A	G	I	S	Q	A	T	V	N	R	M	R	G	V	L	L	G
Secondary structure
SS confidence
Disorder																																				?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 58%) Beta strand ( 6%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 2oz5 chain A Region: 4 - 276 Aligned: 265 Modelled: 273 Confidence: 100.0% Identity: 95% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:phosphotyrosine protein phosphatase ptpb; PDBTitle: crystal structure of mycobacterium tuberculosis protein tyrosine2 phosphatase ptpb in complex with the specific inhibitor omts Phyre2 PDB 1ywf chain A domain 1 Region: 4 - 275 Aligned: 241 Modelled: 241 Confidence: 100.0% Identity: 100% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Mycobacterial PtpB-like Phyre2 PDB 1xri chain A Region: 10 - 203 Aligned: 137 Modelled: 148 Confidence: 99.9% Identity: 24% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 6byf chain I Region: 10 - 191 Aligned: 121 Modelled: 126 Confidence: 99.8% Identity: 22% PDB header:transferase Chain: I: PDB Molecule:tyrosine-protein phosphatase siw14; PDBTitle: crystal structure of the core catalytic domain of pp-ip phosphatase2 siw14 from s. cerevisiae in complex with citrate Phyre2 PDB 2m3v chain A Region: 4 - 210 Aligned: 142 Modelled: 153 Confidence: 99.7% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: solution structure of tyrosine phosphatase related to biofilm2 formation a (tpba) from pseudomonas aeruginosa Phyre2 PDB 2f46 chain A Region: 27 - 205 Aligned: 123 Modelled: 127 Confidence: 99.6% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a putative phosphatase (nma1982) from neisseria2 meningitidis z2491 at 1.41 a resolution Phyre2 PDB 3gxg chain A Region: 5 - 251 Aligned: 146 Modelled: 159 Confidence: 99.3% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:putative phosphatase (duf442); PDBTitle: crystal structure of putative phosphatase (duf442) (yp_001181608.1)2 from shewanella putrefaciens cn-32 at 1.60 a resolution Phyre2 PDB 2img chain A Region: 22 - 187 Aligned: 112 Modelled: 118 Confidence: 99.3% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 23; PDBTitle: crystal structure of dual specificity protein phosphatase2 23 from homo sapiens in complex with ligand malate ion Phyre2 PDB 1fpz chain A Region: 38 - 187 Aligned: 102 Modelled: 102 Confidence: 99.2% Identity: 22% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 2i6o chain A Region: 22 - 187 Aligned: 113 Modelled: 115 Confidence: 99.2% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:sulfolobus solfataricus protein tyrosine PDBTitle: crystal structure of the complex of the archaeal sulfolobus2 ptp-fold phosphatase with phosphopeptides n-g-(p)y-k-n Phyre2 PDB 4r30 chain C Region: 27 - 251 Aligned: 142 Modelled: 148 Confidence: 99.1% Identity: 26% PDB header:hydrolase Chain: C: PDB Molecule:laforin; PDBTitle: structure of human laforin dual specificity phosphatase domain Phyre2 PDB 1yz4 chain A Region: 13 - 209 Aligned: 138 Modelled: 150 Confidence: 99.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase-like 15 isoform a; PDBTitle: crystal structure of dusp15 Phyre2 PDB 2g6z chain B Region: 19 - 209 Aligned: 133 Modelled: 138 Confidence: 99.1% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:dual specificity protein phosphatase 5; PDBTitle: crystal structure of human dusp5 Phyre2 PDB 1fpz chain F Region: 28 - 187 Aligned: 112 Modelled: 112 Confidence: 99.1% Identity: 21% PDB header:hydrolase Chain: F: PDB Molecule:cyclin-dependent kinase inhibitor 3; PDBTitle: crystal structure analysis of kinase associated phosphatase (kap) with2 a substitution of the catalytic site cysteine (cys140) to a serine Phyre2 PDB 1wrm chain A Region: 15 - 209 Aligned: 136 Modelled: 141 Confidence: 99.0% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase 22; PDBTitle: crystal structure of jsp-1 Phyre2 PDB 1mkp chain A Region: 18 - 209 Aligned: 136 Modelled: 145 Confidence: 99.0% Identity: 15% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 2r0b chain A Region: 20 - 209 Aligned: 139 Modelled: 143 Confidence: 99.0% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:serine/threonine/tyrosine-interacting protein; PDBTitle: crystal structure of human tyrosine phosphatase-like2 serine/threonine/tyrosine-interacting protein Phyre2 PDB 2e0t chain A Region: 20 - 187 Aligned: 117 Modelled: 122 Confidence: 99.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity phosphatase 26; PDBTitle: crystal structure of catalytic domain of dual specificity phosphatase2 26, ms0830 from homo sapiens Phyre2 PDB 1m3g chain A Region: 17 - 187 Aligned: 114 Modelled: 124 Confidence: 99.0% Identity: 23% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 2oud chain A Region: 20 - 209 Aligned: 134 Modelled: 143 Confidence: 99.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:dual specificity protein phosphatase 10; PDBTitle: crystal structure of the catalytic domain of human mkp5 Phyre2 1 c2oz5A_ 2 d1ywfa1 3 d1xria_ 4 c6byfI_ 5 c2m3vA_ 6 c2f46A_ 7 c3gxgA_ 8 c2imgA_ 9 d1fpza_ 10 c2i6oA_ 11 c4r30C_ 12 c1yz4A_ 13 c2g6zB_ 14 c1fpzF_ 15 c1wrmA_ 16 d1mkpa_ 17 c2r0bA_ 18 c2e0tA_ 19 d1m3ga_ 20 c2oudA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185