1

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10

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20

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30

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40

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.

Sequence

V

M

D

P

S

P

D

Y

D

V

S

D

E

I

E

F

F

F

R

Y

L

T

W

G

L

R

G

V

E

T

G

D

G

Y

P

P

P

A

Y

P

P

V

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 40%) Alpha helix ( 40%) Beta strand ( 0%)

Rank Aligned region

PDB 3j6r chain C Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 13.6% Identity: 53% PDB header:virus Chain: C: PDB Molecule:major capsid protein l1; PDBTitle: electron cryo-microscopy of human papillomavirus type 16 capsid Phyre2 PDB 3iyj chain E Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 12.8% Identity: 40% PDB header:virus Chain: E: PDB Molecule:major capsid protein l1; PDBTitle: bovine papillomavirus type 1 outer capsid Phyre2 PDB 1dzl chain A Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 12.1% Identity: 53% Fold: Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily: Group I dsDNA viruses Family: Papovaviridae-like VP Phyre2 PDB 1dzl chain A Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 12.1% Identity: 53% PDB header:virus Chain: A: PDB Molecule:late major capsid protein l1; PDBTitle: l1 protein of human papillomavirus 16 Phyre2 PDB 2r5i chain L Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 11.7% Identity: 53% PDB header:viral protein Chain: L: PDB Molecule:l1 protein; PDBTitle: pentamer structure of major capsid protein l1 of human papilloma virus2 type 18 Phyre2 PDB 2r5k chain E Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 10.5% Identity: 47% PDB header:viral protein Chain: E: PDB Molecule:major capsid protein l1; PDBTitle: pentamer structure of major capsid protein l1 of human papilloma virus2 type 11 Phyre2 PDB 6igd chain G Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 10.4% Identity: 47% PDB header:structural protein Chain: G: PDB Molecule:major capsid protein l1; PDBTitle: crystal structure of hpv58/33 chimeric l1 pentamer Phyre2 PDB 1w0b chain A Region: 10 - 27 Aligned: 18 Modelled: 18 Confidence: 9.2% Identity: 28% Fold: Spectrin repeat-like Superfamily: Alpha-hemoglobin stabilizing protein AHSP Family: Alpha-hemoglobin stabilizing protein AHSP Phyre2 PDB 5vgb chain B Region: 6 - 20 Aligned: 15 Modelled: 15 Confidence: 8.8% Identity: 47% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:anti-crispr protein (acriic1); PDBTitle: crystal structure of nmecas9 hnh domain bound to anti-crispr acriic1 Phyre2 PDB 1z8u chain A domain 1 Region: 10 - 27 Aligned: 18 Modelled: 18 Confidence: 8.6% Identity: 28% Fold: Spectrin repeat-like Superfamily: Alpha-hemoglobin stabilizing protein AHSP Family: Alpha-hemoglobin stabilizing protein AHSP Phyre2 PDB 4v00 chain B Region: 28 - 36 Aligned: 9 Modelled: 9 Confidence: 8.4% Identity: 44% PDB header:antimicrobial protein Chain: B: PDB Molecule:monotreme lactating protein; PDBTitle: structural and functional characterization of a novel monotreme-2 specific protein from the milk of the platypus Phyre2 PDB 1t4w chain A Region: 8 - 19 Aligned: 12 Modelled: 12 Confidence: 7.0% Identity: 33% Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily: p53-like transcription factors Family: p53 DNA-binding domain-like Phyre2 PDB 5m45 chain I Region: 34 - 42 Aligned: 9 Modelled: 9 Confidence: 6.8% Identity: 44% PDB header:ligase Chain: I: PDB Molecule:acetone carboxylase gamma subunit; PDBTitle: structure of acetone carboxylase purified from xanthobacter2 autotrophicus Phyre2 PDB 5l9w chain C Region: 34 - 42 Aligned: 9 Modelled: 9 Confidence: 6.1% Identity: 44% PDB header:ligase Chain: C: PDB Molecule:acetophenone carboxylase beta subunit; PDBTitle: crystal structure of the apc core complex Phyre2 PDB 3sqi chain A Region: 22 - 35 Aligned: 14 Modelled: 14 Confidence: 6.0% Identity: 36% PDB header:dna binding protein/dna Chain: A: PDB Molecule:klla0e03807p; PDBTitle: dna binding domain of ndc10 Phyre2 PDB 3t79 chain A Region: 22 - 35 Aligned: 14 Modelled: 14 Confidence: 6.0% Identity: 36% PDB header:dna binding protein/dna Chain: A: PDB Molecule:klla0e03807p; PDBTitle: ndc10: a platform for inner kinetochore assembly in budding yeast Phyre2 PDB 2d6f chain C domain 3 Region: 6 - 33 Aligned: 28 Modelled: 28 Confidence: 5.4% Identity: 21% Fold: Glutamine synthetase/guanido kinase Superfamily: Glutamine synthetase/guanido kinase Family: GatB/GatE catalytic domain-like Phyre2 1 c3j6rC_ 2 c3iyjE_ 3 d1dzla_ 4 c1dzlA_ 5 c2r5iL_ 6 c2r5kE_ 7 c6igdG_ 8 d1w0ba_ 9 c5vgbB_ 10 d1z8ua1 11 c4v00B_ 12 d1t4wa_ 13 c5m45I_ 14 c5l9wC_ 15 c3sqiA_ 16 c3t79A_ 17 d2d6fc3