1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	H	L	V	T	A	P	D	M	L	A	T	A	A	A	H	V	D	E	I	A	S	T	L	R	A	A	N	A	A	A	A	G	P	T	C	N	L	L	A	A	A	G	D	E	V	S	A	A	T	A	A	L	F	S	A	Y	G	R
Secondary structure
SS confidence
Disorder		?	?	?			?	?																					?	?	?							?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	Y	Q	A	V	V	K	Q	A	A	A	F	H	S	E	F	T	R	T	L	E	A	A	G	N	A	Y	A	H	A	E	A	A	N	A	A	R	V	S	H	A	L	D	T	I	N	A	P	I	R	T	L	L	G	R	A	P	L	S	P
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	G	S	S	G	A	G	G	L	P	A	I	A	Q	L	A	A	E	S	P	I	T	A	L	I	M	G	G	T	N	N	P	L	P	D	P	E	Y	V	T	D	I	N	K	A	F	I	Q	T	L	F	P	G	A	V	S	Q	G	L	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?	?	?	?		?			?	?	?	?	?	?	?	?		?		?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	P	E	Q	F	W	P	V	T	P	D	L	G	N	L	T	F	N	Q	S	V	T	E	G	V	A	L	L	N	T	A	V	N	N	Q	L	A	L	D	N	K	V	V	A	F	G	Y	S	Q	S	A	T	I	I	N	N	Y	I	N	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	M	A	M	G	S	P	N	P	D	D	I	S	F	V	M	I	G	S	G	N	N	P	V	G	G	L	L	A	R	F	P	G	F	Y	I	P	F	L	D	V	P	F	N	G	A	T	P	A	N	S	P	Y	P	T	H	I	Y	T	A
Secondary structure
SS confidence
Disorder				?	?	?	?	?															?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	Y	D	G	I	A	H	A	P	Q	F	P	L	R	I	L	S	D	I	N	A	F	M	G	Y	F	Y	V	H	N	T	Y	P	E	L	M	A	T	Q	V	D	N	A	V	P	L	P	T	S	P	G	Y	T	G	N	T	Q	Y	Y	M
Secondary structure
SS confidence
Disorder																																					?					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		F	L	T	Q	D	L	P	L	L	Q	P	I	R	D	I	P	Y	A	G	P	P	I	A	D	L	F	Q	P	Q	L	R	V	L	V	D	L	G	Y	A	D	Y	G	P	G	G	N	Y	A	D	I	P	T	P	A	G	L	F	S	I	P
Secondary structure
SS confidence
Disorder																	?																											?	?	?	?									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		N	P	F	A	V	T	Y	Y	L	I	K	G	S	L	Q	A	P	Y	G	A	I	V	E	I	G	V	E	A	G	L	I	G	P	E	W	F	P	D	S	Y	P	W	V	P	S	I	N	P	G	L	N	F	Y	F	G	Q	P	Q	V	T
Secondary structure
SS confidence
Disorder				?	?	?	?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.
Sequence		L	L	S	L	M	S	G	G	L	G	N	I	L	H	L	I	P	P	P	V	F	T
Secondary structure
SS confidence
Disorder		?																	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 24%) Alpha helix ( 44%) Beta strand ( 6%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 5xfs chain A Region: 7 - 84 Aligned: 78 Modelled: 78 Confidence: 100.0% Identity: 47% PDB header:protein transport Chain: A: PDB Molecule:pe family protein pe8; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain A Region: 8 - 84 Aligned: 77 Modelled: 77 Confidence: 100.0% Identity: 29% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:pe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 2g38 chain A domain 1 Region: 8 - 84 Aligned: 77 Modelled: 77 Confidence: 100.0% Identity: 29% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PE Phyre2 PDB 3aja chain A Region: 142 - 336 Aligned: 195 Modelled: 195 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of msmeg_6394 Phyre2 PDB 1qoz chain A Region: 140 - 332 Aligned: 171 Modelled: 179 Confidence: 99.6% Identity: 20% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 1g66 chain A Region: 140 - 332 Aligned: 172 Modelled: 179 Confidence: 99.5% Identity: 18% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 2czq chain B Region: 134 - 332 Aligned: 175 Modelled: 199 Confidence: 99.5% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:cutinase-like protein; PDBTitle: a novel cutinase-like protein from cryptococcus sp. Phyre2 PDB 3hc7 chain A Region: 142 - 323 Aligned: 170 Modelled: 182 Confidence: 99.4% Identity: 18% PDB header:cell adhesion Chain: A: PDB Molecule:gene 12 protein; PDBTitle: crystal structure of lysin b from mycobacteriophage d29 Phyre2 PDB 1cex chain A Region: 142 - 332 Aligned: 151 Modelled: 160 Confidence: 99.2% Identity: 17% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Cutinase-like Phyre2 PDB 3dd5 chain F Region: 125 - 332 Aligned: 170 Modelled: 177 Confidence: 99.2% Identity: 16% PDB header:hydrolase Chain: F: PDB Molecule:cutinase; PDBTitle: glomerella cingulata e600-cutinase complex Phyre2 PDB 5x88 chain A Region: 142 - 307 Aligned: 140 Modelled: 148 Confidence: 99.1% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:cutinase; PDBTitle: a crystal structure of cutinases from malbranchea cinnamomea Phyre2 PDB 3gbs chain A Region: 140 - 334 Aligned: 156 Modelled: 177 Confidence: 99.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:cutinase 1; PDBTitle: crystal structure of aspergillus oryzae cutinase Phyre2 PDB 4psd chain A Region: 126 - 307 Aligned: 147 Modelled: 161 Confidence: 98.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:carbohydrate esterase family 5; PDBTitle: structure of trichoderma reesei cutinase native form. Phyre2 PDB 4oyl chain C Region: 134 - 307 Aligned: 149 Modelled: 156 Confidence: 98.9% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:cutinase; PDBTitle: humicola insolens cutinase in complex with mono-ethylphosphate Phyre2 PDB 5xfs chain B Region: 9 - 93 Aligned: 85 Modelled: 85 Confidence: 98.6% Identity: 21% PDB header:protein transport Chain: B: PDB Molecule:ppe family protein ppe15; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain B domain 1 Region: 9 - 96 Aligned: 88 Modelled: 88 Confidence: 98.6% Identity: 10% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PPE Phyre2 PDB 2g38 chain B Region: 9 - 96 Aligned: 88 Modelled: 88 Confidence: 98.6% Identity: 10% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:ppe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 4xy3 chain A Region: 9 - 93 Aligned: 79 Modelled: 85 Confidence: 98.3% Identity: 13% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 3icv chain A Region: 185 - 305 Aligned: 108 Modelled: 121 Confidence: 95.5% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:lipase b; PDBTitle: structural consequences of a circular permutation on lipase b from2 candida antartica Phyre2 PDB 5xav chain B Region: 162 - 255 Aligned: 93 Modelled: 94 Confidence: 94.7% Identity: 23% PDB header:biosynthetic protein Chain: B: PDB Molecule:intracellular polyhydroxyalkanoate synthase; PDBTitle: structure of phac from chromobacterium sp. usm2 Phyre2 1 c5xfsA_ 2 c2g38A_ 3 d2g38a1 4 c3ajaA_ 5 d1qoza_ 6 d1g66a_ 7 c2czqB_ 8 c3hc7A_ 9 d1cexa_ 10 c3dd5F_ 11 c5x88A_ 12 c3gbsA_ 13 c4psdA_ 14 c4oylC_ 15 c5xfsB_ 16 d2g38b1 17 c2g38B_ 18 c4xy3A_ 19 c3icvA_ 20 c5xavB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154