1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	T	S	L	V	S	A	V	G	S	H	H	V	T	T	D	P	D	V	L	A	G	R	S	V	D	H	T	G	R	Y	R	G	R	A	S	A	L	V	R	P	G	S	A	E	E	V	A	E	V	L	R	V	C	R	D	A	G	A
Secondary structure
SS confidence
Disorder		?	?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	V	T	V	Q	G	G	R	T	S	L	V	A	G	T	V	P	E	H	D	D	V	L	L	S	T	E	R	L	C	V	V	S	D	V	D	T	V	E	R	R	I	E	I	G	A	G	V	T	L	A	A	V	Q	H	A	A	S	T	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	V	F	G	V	D	L	S	A	R	D	T	A	T	V	G	G	M	A	S	T	N	A	G	G	L	R	T	V	R	Y	G	N	M	G	E	Q	V	V	G	L	D	V	A	L	P	D	G	T	V	L	R	R	H	S	R	V	R	R
Secondary structure
SS confidence
Disorder														?																																								?			?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		D	N	T	G	Y	D	L	P	A	L	F	V	G	A	E	G	T	L	G	V	I	T	A	L	D	L	R	L	H	P	T	P	S	H	R	V	T	A	V	C	G	F	A	E	L	A	A	L	V	D	A	G	R	M	F	R	D	V	E	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	A	A	L	E	L	I	D	G	R	A	A	A	L	T	R	E	H	L	G	V	R	P	P	V	E	A	D	W	L	L	L	V	E	L	A	A	D	H	D	Q	T	D	R	L	A	D	L	L	G	G	A	R	M	C	G	E	P	A	V
Secondary structure
SS confidence
Disorder																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	V	D	A	A	A	Q	Q	R	L	W	R	T	R	E	S	L	A	E	V	L	G	V	Y	G	P	P	L	K	F	D	V	S	L	P	L	S	A	I	S	G	F	A	R	D	A	V	A	L	V	H	R	H	V	P	D	S	P	E	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	P	L	L	F	G	H	I	G	E	G	N	L	H	L	N	V	L	R	C	P	P	D	R	E	P	A	L	Y	A	K	M	M	G	L	I	A	E	C	G	G	N	V	S	S	E	H	G	V	G	S	R	K	R	A	Y	L	G	M	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.
Sequence		R	Q	A	N	D	V	A	A	M	R	R	V	K	A	A	L	D	P	T	G	Y	L	N	A	A	V	L	F	D
Secondary structure
SS confidence
Disorder																											?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 3%) Alpha helix ( 35%) Beta strand ( 25%) TM helix ( 7%) (View membrane topology prediction)

Rank Aligned region

PDB 3pm9 chain A Region: 1 - 448 Aligned: 445 Modelled: 445 Confidence: 100.0% Identity: 32% PDB header:oxidoreductase Chain: A: PDB Molecule:putative oxidoreductase; PDBTitle: crystal structure of a putative dehydrogenase (rpa1076) from2 rhodopseudomonas palustris cga009 at 2.57 a resolution Phyre2 PDB 4bc9 chain C Region: 2 - 448 Aligned: 444 Modelled: 447 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: C: PDB Molecule:alkyldihydroxyacetonephosphate synthase, peroxisomal; PDBTitle: mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct2 with cyanoethyl Phyre2 PDB 3bw7 chain A Region: 3 - 449 Aligned: 439 Modelled: 447 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:cytokinin dehydrogenase 1; PDBTitle: maize cytokinin oxidase/dehydrogenase complexed with the allenic2 cytokinin analog ha-1 Phyre2 PDB 5fxp chain A Region: 2 - 449 Aligned: 438 Modelled: 448 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:eugenol oxidase; PDBTitle: crystal structure of eugenol oxidase in complex with2 vanillin Phyre2 PDB 4oal chain B Region: 11 - 449 Aligned: 422 Modelled: 438 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: B: PDB Molecule:cytokinin dehydrogenase 4; PDBTitle: crystal structure of maize cytokinin oxidase/dehydrogenase 4 (zmcko4)2 in complex with phenylurea inhibitor cppu in alternative spacegroup Phyre2 PDB 1wve chain B Region: 2 - 447 Aligned: 444 Modelled: 446 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:4-cresol dehydrogenase [hydroxylating] PDBTitle: p-cresol methylhydroxylase: alteration of the structure of2 the flavoprotein subunit upon its binding to the3 cytochrome subunit Phyre2 PDB 4ml8 chain C Region: 1 - 449 Aligned: 437 Modelled: 447 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: C: PDB Molecule:cytokinin oxidase 2; PDBTitle: structure of maize cytokinin oxidase/dehydrogenase 2 (zmcko2) Phyre2 PDB 1ahu chain B Region: 1 - 448 Aligned: 438 Modelled: 448 Confidence: 100.0% Identity: 15% PDB header:flavoenzyme Chain: B: PDB Molecule:vanillyl-alcohol oxidase; PDBTitle: structure of the octameric flavoenzyme vanillyl-alcohol2 oxidase in complex with p-cresol Phyre2 PDB 2exr chain A Region: 7 - 449 Aligned: 433 Modelled: 431 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: A: PDB Molecule:cytokinin dehydrogenase 7; PDBTitle: x-ray structure of cytokinin oxidase/dehydrogenase (ckx) from2 arabidopsis thaliana at5g21482 Phyre2 PDB 2uuv chain C Region: 1 - 444 Aligned: 394 Modelled: 411 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: C: PDB Molecule:alkyldihydroxyacetonephosphate synthase; PDBTitle: alkyldihydroxyacetonephosphate synthase in p1 Phyre2 PDB 6c80 chain B Region: 23 - 449 Aligned: 418 Modelled: 427 Confidence: 100.0% Identity: 18% PDB header:immune system Chain: B: PDB Molecule:cytokinin oxidase luckx1.1; PDBTitle: crystal structure of a flax cytokinin oxidase Phyre2 PDB 3vte chain A Region: 1 - 448 Aligned: 435 Modelled: 448 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: A: PDB Molecule:tetrahydrocannabinolic acid synthase; PDBTitle: crystal structure of tetrahydrocannabinolic acid synthase from2 cannabis sativa Phyre2 PDB 1f0x chain A Region: 1 - 446 Aligned: 427 Modelled: 431 Confidence: 100.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:d-lactate dehydrogenase; PDBTitle: crystal structure of d-lactate dehydrogenase, a peripheral membrane2 respiratory enzyme. Phyre2 PDB 2bvf chain A Region: 9 - 449 Aligned: 424 Modelled: 432 Confidence: 100.0% Identity: 16% PDB header:oxidase Chain: A: PDB Molecule:6-hydroxy-d-nicotine oxidase; PDBTitle: crystal structure of 6-hydoxy-d-nicotine oxidase from2 arthrobacter nicotinovorans. crystal form 3 (p1) Phyre2 PDB 4ud8 chain B Region: 2 - 447 Aligned: 435 Modelled: 446 Confidence: 100.0% Identity: 12% PDB header:oxidoreductase Chain: B: PDB Molecule:fad-binding and bbe domain-containing protein; PDBTitle: atbbe15 Phyre2 PDB 3tsj chain A Region: 2 - 445 Aligned: 426 Modelled: 432 Confidence: 100.0% Identity: 13% PDB header:allergen, oxidoreductase Chain: A: PDB Molecule:pollen allergen phl p 4; PDBTitle: crystal structure of phl p 4, a grass pollen allergen with glucose2 dehydrogenase activity Phyre2 PDB 3rja chain A Region: 1 - 448 Aligned: 431 Modelled: 447 Confidence: 100.0% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:carbohydrate oxidase; PDBTitle: crystal structure of carbohydrate oxidase from microdochium nivale in2 complex with substrate analogue Phyre2 PDB 3w8w chain A Region: 1 - 448 Aligned: 435 Modelled: 448 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase Chain: A: PDB Molecule:putative fad-dependent oxygenase encm; PDBTitle: the crystal structure of encm Phyre2 PDB 4fdo chain A Region: 26 - 444 Aligned: 399 Modelled: 415 Confidence: 100.0% Identity: 17% PDB header:oxidoreductase/oxidoreductase inhibitor Chain: A: PDB Molecule:oxidoreductase dpre1; PDBTitle: mycobacterium tuberculosis dpre1 in complex with ct319 Phyre2 PDB 6eo5 chain A Region: 1 - 446 Aligned: 428 Modelled: 446 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:ppbbe-like 1 d396n; PDBTitle: physcomitrella patens bbe-like 1 variant d396n Phyre2 1 c3pm9A_ 2 c4bc9C_ 3 c3bw7A_ 4 c5fxpA_ 5 c4oalB_ 6 c1wveB_ 7 c4ml8C_ 8 c1ahuB_ 9 c2exrA_ 10 c2uuvC_ 11 c6c80B_ 12 c3vteA_ 13 c1f0xA_ 14 c2bvfA_ 15 c4ud8B_ 16 c3tsjA_ 17 c3rjaA_ 18 c3w8wA_ 19 c4fdoA_ 20 c6eo5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150