1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	T	P	G	K	L	N	K	A	R	V	P	P	Y	K	T	A	G	L	G	L	V	L	V	F	A	L	V	V	A	L	V	Y	L	Q	F	R	G	E	F	T	P	K	T	Q	L	T	M	L	S	A	R	A	G	L	V	M	D	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?																								?	?	?															?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	S	K	V	T	Y	N	G	V	E	I	G	R	V	D	T	I	S	E	V	T	R	D	G	E	S	A	A	K	F	I	L	D	V	D	P	R	Y	I	H	L	I	P	A	N	V	N	A	D	I	K	A	T	T	V	F	G	G	K	Y
Secondary structure
SS confidence
Disorder																					?	?	?	?														?	?	?	?	?												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	S	L	T	T	P	K	N	P	T	K	R	R	I	T	P	K	D	V	I	D	V	R	S	V	T	T	E	I	N	T	L	F	Q	T	L	T	S	I	A	E	K	V	D	P	V	K	L	N	L	T	L	S	A	A	A	E	A	L	T
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?														?	?																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	L	G	D	K	F	G	E	S	I	V	N	A	N	T	V	L	D	D	L	N	S	R	M	P	Q	S	R	H	D	I	Q	Q	L	A	A	L	G	D	V	Y	A	D	A	A	P	D	L	F	D	F	L	D	S	S	V	T	T	A	R
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	I	N	A	Q	Q	A	E	L	D	S	A	L	L	A	A	A	G	F	G	N	T	T	A	D	V	F	D	R	G	G	P	Y	L	Q	R	G	V	A	D	L	V	P	T	A	T	L	L	D	T	Y	S	P	E	L	F	C	T	I	R
Secondary structure
SS confidence
Disorder						?																																														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	F	Y	D	A	D	P	L	A	K	A	A	S	G	G	G	N	G	Y	S	L	R	T	N	S	E	I	L	S	G	I	G	I	S	L	L	S	P	L	A	L	A	T	N	G	A	A	I	G	I	G	L	V	A	G	L	I	A	P	P
Secondary structure
SS confidence
Disorder													?																		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		L	A	V	A	A	N	L	A	G	A	L	P	G	I	V	G	G	A	P	N	P	Y	T	Y	P	E	N	L	P	R	V	N	A	R	G	G	P	G	G	A	P	G	C	W	Q	P	I	T	R	D	L	W	P	A	P	Y	L	V	M	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?		?		?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.
Sequence		T	G	A	S	L	A	P	Y	N	H	M	E	V	G	S	P	Y	A	V	E	Y	V	W	G	R	Q	V	G	D	N	T	I	N	P
Secondary structure
SS confidence
Disorder						?				?	?	?	?																?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 35%) Alpha helix ( 41%) Beta strand ( 13%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 19 - 154 Aligned: 133 Modelled: 136 Confidence: 99.9% Identity: 21% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 42 - 146 Aligned: 100 Modelled: 105 Confidence: 99.7% Identity: 21% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain D Region: 41 - 164 Aligned: 112 Modelled: 124 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain C Region: 41 - 164 Aligned: 112 Modelled: 124 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain F Region: 41 - 164 Aligned: 112 Modelled: 124 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain E Region: 41 - 164 Aligned: 112 Modelled: 124 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 41 - 164 Aligned: 112 Modelled: 124 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain B Region: 41 - 164 Aligned: 112 Modelled: 124 Confidence: 99.5% Identity: 19% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 3g67 chain A Region: 149 - 312 Aligned: 162 Modelled: 164 Confidence: 82.0% Identity: 9% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima Phyre2 PDB 1qu7 chain A Region: 149 - 302 Aligned: 150 Modelled: 154 Confidence: 81.8% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 2j5u chain B Region: 67 - 102 Aligned: 36 Modelled: 36 Confidence: 68.3% Identity: 14% PDB header:cell shape regulation Chain: B: PDB Molecule:mrec protein; PDBTitle: mrec lysteria monocytogenes Phyre2 PDB 5jxp chain A Region: 376 - 440 Aligned: 65 Modelled: 65 Confidence: 62.6% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:asp/glu-specific dipeptidyl-peptidase; PDBTitle: crystal structure of porphyromonas endodontalis dpp11 in alternate2 conformation Phyre2 PDB 1szi chain A Region: 166 - 293 Aligned: 111 Modelled: 111 Confidence: 62.5% Identity: 16% Fold: Four-helical up-and-down bundle Superfamily: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain Family: Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain Phyre2 PDB 2qf4 chain A Region: 67 - 102 Aligned: 36 Modelled: 36 Confidence: 58.3% Identity: 17% PDB header:structural protein Chain: A: PDB Molecule:cell shape determining protein mrec; PDBTitle: high resolution structure of the major periplasmic domain from the2 cell shape-determining filament mrec (orthorhombic form) Phyre2 PDB 4abx chain B Region: 146 - 277 Aligned: 129 Modelled: 132 Confidence: 55.9% Identity: 13% PDB header:dna binding protein Chain: B: PDB Molecule:dna repair protein recn; PDBTitle: crystal structure of deinococcus radiodurans recn coiled-2 coil domain Phyre2 PDB 3lnr chain A Region: 166 - 291 Aligned: 126 Modelled: 126 Confidence: 52.4% Identity: 10% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 5xbj chain A Region: 166 - 281 Aligned: 116 Modelled: 116 Confidence: 50.7% Identity: 13% PDB header:biosynthetic protein Chain: A: PDB Molecule:flagellar hook-associated protein flgk; PDBTitle: the structure of the flagellar hook junction protein hap1 (flgk) from2 campylobacter jejuni Phyre2 PDB 6e6a chain B Region: 152 - 312 Aligned: 156 Modelled: 161 Confidence: 50.1% Identity: 15% PDB header:protein binding Chain: B: PDB Molecule:inclusion membrane protein a; PDBTitle: triclinic crystal form of inca g144a point mutant Phyre2 PDB 3q5x chain A Region: 156 - 290 Aligned: 111 Modelled: 111 Confidence: 49.7% Identity: 12% PDB header:cell cycle Chain: A: PDB Molecule:protein cut8; PDBTitle: structure of proteasome tether Phyre2 PDB 3cwg chain A Region: 149 - 281 Aligned: 133 Modelled: 133 Confidence: 48.0% Identity: 12% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnD_ 4 c5uvnC_ 5 c5uvnF_ 6 c5uvnE_ 7 c5uvnA_ 8 c5uvnB_ 9 c3g67A_ 10 c1qu7A_ 11 c2j5uB_ 12 c5jxpA_ 13 d1szia_ 14 c2qf4A_ 15 c4abxB_ 16 c3lnrA_ 17 c5xbjA_ 18 c6e6aB_ 19 c3q5xA_ 20 c3cwgA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99