1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	S	V	L	A	R	M	R	V	M	R	H	R	A	W	Q	G	L	V	L	L	V	L	A	L	L	L	S	S	C	G	W	R	G	I	S	N	V	A	I	P	G	G	P	G	T	G	P	G	S	Y	T	I	Y	V	Q	M	P	D
Secondary structure
SS confidence
Disorder		?	?	?	?																																				?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	L	A	I	N	G	N	S	R	V	M	V	A	D	V	W	V	G	S	I	R	A	I	K	L	K	N	W	V	A	T	L	T	L	S	L	K	K	D	V	T	L	P	K	N	A	T	A	K	I	G	Q	T	S	L	L	G	S	Q	H
Secondary structure
SS confidence
Disorder			?		?	?	?	?																			?												?				?											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	E	L	A	A	P	P	D	P	S	P	V	P	L	K	D	G	D	T	I	P	L	K	R	S	S	A	Y	P	T	T	E	Q	T	L	A	S	I	A	T	L	L	R	G	G	G	L	V	N	L	E	G	I	Q	Q	E	I	N	A	I
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?	?		?	?				?		?	?	?	?	?	?	?														?		?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	T	G	R	A	D	Q	I	R	A	F	L	G	K	L	D	T	F	T	D	E	L	N	Q	Q	R	D	D	I	T	R	A	I	D	S	T	N	R	L	L	A	Y	V	G	G	R	S	E	V	L	N	R	V	L	T	D	L	P	P	L
Secondary structure
SS confidence
Disorder			?	?	?	?																			?	?																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	K	H	F	A	D	K	Q	E	L	L	I	N	A	S	D	A	V	G	R	L	S	Q	S	A	D	Q	Y	L	S	A	A	R	G	D	L	H	Q	D	L	Q	A	L	Q	C	P	L	K	E	L	R	R	A	A	P	Y	L	V	G	A
Secondary structure
SS confidence
Disorder																																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	K	L	I	L	T	Q	P	F	D	V	D	T	V	P	Q	L	V	R	G	D	Y	M	N	L	S	L	T	L	D	L	T	Y	S	A	I	D	N	A	F	L	T	G	T	G	F	S	G	A	L	R	A	L	E	Q	S	F	G	R	D
Secondary structure
SS confidence
Disorder											?	?		?	?	?	?																					?	?	?			?	?				?	?	?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390
Sequence		P	E	T	M	I	P	D	I	R	Y	T	P	N	P	N	D	A	P	G	G	P	L	V	E	R	G	N	R	Q	C
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?					?	?	?				?					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 48%) Beta strand ( 15%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 21 - 156 Aligned: 132 Modelled: 136 Confidence: 99.9% Identity: 20% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 49 - 146 Aligned: 97 Modelled: 98 Confidence: 99.9% Identity: 26% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain D Region: 48 - 166 Aligned: 105 Modelled: 119 Confidence: 99.5% Identity: 12% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain F Region: 48 - 166 Aligned: 105 Modelled: 119 Confidence: 99.5% Identity: 12% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain C Region: 48 - 166 Aligned: 105 Modelled: 119 Confidence: 99.5% Identity: 12% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 48 - 166 Aligned: 105 Modelled: 119 Confidence: 99.5% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain E Region: 48 - 166 Aligned: 105 Modelled: 119 Confidence: 99.5% Identity: 12% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain B Region: 48 - 166 Aligned: 105 Modelled: 119 Confidence: 99.5% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 1qu7 chain A Region: 151 - 304 Aligned: 150 Modelled: 154 Confidence: 89.7% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 2wpq chain A Region: 188 - 287 Aligned: 99 Modelled: 100 Confidence: 88.4% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:trimeric autotransporter adhesin fragment; PDBTitle: salmonella enterica sada 479-519 fused to gcn4 adaptors (sadak3, in-2 register fusion) Phyre2 PDB 3zx6 chain A Region: 179 - 304 Aligned: 122 Modelled: 126 Confidence: 84.0% Identity: 14% PDB header:signaling Chain: A: PDB Molecule:hamp, methyl-accepting chemotaxis protein i; PDBTitle: structure of hamp(af1503)-tsr fusion - hamp (a291v) mutant Phyre2 PDB 2j5u chain B Region: 55 - 115 Aligned: 55 Modelled: 61 Confidence: 82.4% Identity: 13% PDB header:cell shape regulation Chain: B: PDB Molecule:mrec protein; PDBTitle: mrec lysteria monocytogenes Phyre2 PDB 5u0p chain U Region: 181 - 294 Aligned: 110 Modelled: 114 Confidence: 82.3% Identity: 11% PDB header:transcription Chain: U: PDB Molecule:mediator complex subunit 21; PDBTitle: cryo-em structure of the transcriptional mediator Phyre2 PDB 2qf4 chain A Region: 44 - 140 Aligned: 93 Modelled: 97 Confidence: 81.5% Identity: 13% PDB header:structural protein Chain: A: PDB Molecule:cell shape determining protein mrec; PDBTitle: high resolution structure of the major periplasmic domain from the2 cell shape-determining filament mrec (orthorhombic form) Phyre2 PDB 3lnr chain A Region: 167 - 301 Aligned: 135 Modelled: 135 Confidence: 78.9% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 3g67 chain A Region: 151 - 304 Aligned: 152 Modelled: 154 Confidence: 77.3% Identity: 12% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima Phyre2 PDB 3cwg chain A Region: 151 - 285 Aligned: 135 Modelled: 135 Confidence: 70.6% Identity: 9% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 PDB 1eq1 chain A Region: 151 - 300 Aligned: 141 Modelled: 147 Confidence: 68.4% Identity: 11% Fold: Apolipophorin-III Superfamily: Apolipophorin-III Family: Apolipophorin-III Phyre2 PDB 4rh7 chain A Region: 167 - 318 Aligned: 152 Modelled: 152 Confidence: 66.2% Identity: 7% PDB header:motor protein Chain: A: PDB Molecule:green fluorescent protein/cytoplasmic dynein 2 heavy chain PDBTitle: crystal structure of human cytoplasmic dynein 2 motor domain in2 complex with adp.vi Phyre2 PDB 2qih chain A Region: 174 - 299 Aligned: 122 Modelled: 126 Confidence: 66.0% Identity: 9% PDB header:cell adhesion Chain: A: PDB Molecule:protein uspa1; PDBTitle: crystal structure of 527-665 fragment of uspa1 protein from moraxella2 catarrhalis Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnD_ 4 c5uvnF_ 5 c5uvnC_ 6 c5uvnA_ 7 c5uvnE_ 8 c5uvnB_ 9 c1qu7A_ 10 c2wpqA_ 11 c3zx6A_ 12 c2j5uB_ 13 c5u0pU_ 14 c2qf4A_ 15 c3lnrA_ 16 c3g67A_ 17 c3cwgA_ 18 d1eq1a_ 19 c4rh7A_ 20 c2qihA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99