1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	V	V	V	E	K	T	P	T	T	L	P	Q	A	T	P	N	G	A	A	P	W	H	V	R	A	G	A	F	A	I	D	V	L	P	G	L	A	V	A	A	T	M	A	L	T	A	L	T	V	P	P	G	S	A	W	R	W	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		C	A	C	L	L	G	L	T	I	L	L	L	A	V	N	R	L	L	L	P	T	I	T	G	W	S	L	G	R	A	L	T	G	I	R	V	V	R	R	D	G	S	A	I	G	P	W	R	L	L	V	R	D	L	A	H	L	V	D	T
Secondary structure
SS confidence
Disorder																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	S	L	F	V	G	W	L	W	P	L	W	D	S	R	R	R	T	F	A	D	L	L	L	R	T	E	V	R	R	V	E	P	V	Q	R	P	A	V	I	R	R	L	T	A	A	V	A	L	A	A	A	G	A	C	A	S	A	T	A
Secondary structure
SS confidence
Disorder																																		?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	G	A	A	V	V	Y	V	N	E	W	Q	T	D	H	T	R	A	Q	L	A	T	R	G	P	K	L	V	V	D	V	L	S	Y	D	P	E	T	V	Q	R	D	F	E	R	A	R	S	L	A	T	D	R	Y	R	P	Q	L	S	I
Secondary structure
SS confidence
Disorder									?		?	?	?	?																																			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	Q	D	S	V	R	E	S	G	P	V	R	N	Q	Y	W	V	T	D	S	A	V	L	S	A	T	P	A	Q	A	T	M	L	L	F	M	Q	G	E	R	G	T	P	P	N	Q	R	Y	I	Q	S	T	V	R	A	I	F	Q	K	S
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?				?	?	?	?	?	?	?	?		?										?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Sequence		R	G	Q	W	R	L	D	D	L	A	V	V	M	K	P	R	Q	P	T	G	E	K
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 52%) Beta strand ( 16%) TM helix ( 25%) (View membrane topology prediction)

Rank Aligned region

PDB 5u9o chain D Region: 222 - 314 Aligned: 93 Modelled: 93 Confidence: 96.9% Identity: 10% PDB header:cell cycle Chain: D: PDB Molecule:plastid division protein cdp1, chloroplastic,plastid PDBTitle: cocrystal structure of the intermembrane space region of the plastid2 division proteins parc6 and pdv1 Phyre2 PDB 4i4k chain B Region: 192 - 309 Aligned: 118 Modelled: 118 Confidence: 96.7% Identity: 12% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein sgcj; PDBTitle: streptomyces globisporus c-1027 9-membered enediyne conserved protein2 sgce6 Phyre2 PDB 2ux0 chain A domain 1 Region: 189 - 306 Aligned: 118 Modelled: 118 Confidence: 96.7% Identity: 8% Fold: Cystatin-like Superfamily: NTF2-like Family: Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A Phyre2 PDB 3wz4 chain F Region: 197 - 267 Aligned: 71 Modelled: 71 Confidence: 96.6% Identity: 6% PDB header:unknown function Chain: F: PDB Molecule:doti; PDBTitle: structure of the periplasmic domain of doti (crystal form i) Phyre2 PDB 1hkx chain A Region: 189 - 306 Aligned: 118 Modelled: 118 Confidence: 96.5% Identity: 8% Fold: Cystatin-like Superfamily: NTF2-like Family: Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A Phyre2 PDB 5d9r chain A Region: 201 - 312 Aligned: 111 Modelled: 112 Confidence: 96.4% Identity: 14% PDB header:biosynthetic protein Chain: A: PDB Molecule:protein accumulation and replication of chloroplasts 6, PDBTitle: crystal structure of a conserved domain in the intermembrane space2 region of the plastid division protein arc6 Phyre2 PDB 5cnl chain A Region: 197 - 301 Aligned: 105 Modelled: 105 Confidence: 96.1% Identity: 12% PDB header:protein transport Chain: A: PDB Molecule:icml-like; PDBTitle: crystal structure of an icml-like type iv secretion system protein2 (lpg0120) from legionella pneumophila subsp. pneumophila str.3 philadelphia 1 at 2.65 a resolution Phyre2 PDB 2r4i chain A domain 1 Region: 196 - 306 Aligned: 111 Modelled: 111 Confidence: 96.0% Identity: 9% Fold: Cystatin-like Superfamily: NTF2-like Family: CHU142-like Phyre2 PDB 3d9r chain A domain 1 Region: 194 - 308 Aligned: 113 Modelled: 115 Confidence: 96.0% Identity: 14% Fold: Cystatin-like Superfamily: NTF2-like Family: ECA1476-like Phyre2 PDB 3gzr chain A Region: 195 - 307 Aligned: 113 Modelled: 113 Confidence: 95.9% Identity: 12% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein with a ntf2-like fold; PDBTitle: crystal structure of an uncharacterized protein with a cystatin-like2 fold (cc_2572) from caulobacter vibrioides at 1.40 a resolution Phyre2 PDB 3a76 chain B Region: 196 - 311 Aligned: 116 Modelled: 116 Confidence: 95.5% Identity: 9% PDB header:lyase Chain: B: PDB Molecule:gamma-hexachlorocyclohexane dehydrochlorinase; PDBTitle: the crystal structure of lina Phyre2 PDB 3b8l chain A domain 1 Region: 235 - 320 Aligned: 85 Modelled: 86 Confidence: 95.4% Identity: 8% Fold: Cystatin-like Superfamily: NTF2-like Family: BaiE/LinA-like Phyre2 PDB 4ovm chain E Region: 198 - 307 Aligned: 110 Modelled: 110 Confidence: 95.4% Identity: 9% PDB header:unknown function Chain: E: PDB Molecule:uncharacterized protein sgcj; PDBTitle: crystal structure of sgcj protein from streptomyces carzinostaticus Phyre2 PDB 3eby chain A domain 1 Region: 199 - 320 Aligned: 121 Modelled: 122 Confidence: 95.3% Identity: 14% Fold: Cystatin-like Superfamily: NTF2-like Family: Ring hydroxylating beta subunit Phyre2 PDB 3wz3 chain A Region: 197 - 301 Aligned: 105 Modelled: 105 Confidence: 95.3% Identity: 6% PDB header:unknown function Chain: A: PDB Molecule:tram protein; PDBTitle: structure of a periplasmic fragment of tram Phyre2 PDB 3hx8 chain A Region: 194 - 307 Aligned: 111 Modelled: 113 Confidence: 94.6% Identity: 11% PDB header:isomerase Chain: A: PDB Molecule:putative ketosteroid isomerase; PDBTitle: crystal structure of putative ketosteroid isomerase (np_103587.1) from2 mesorhizobium loti at 1.45 a resolution Phyre2 PDB 3cu3 chain A domain 1 Region: 195 - 309 Aligned: 115 Modelled: 115 Confidence: 94.5% Identity: 10% Fold: Cystatin-like Superfamily: NTF2-like Family: BaiE/LinA-like Phyre2 PDB 2f86 chain B domain 1 Region: 190 - 306 Aligned: 117 Modelled: 117 Confidence: 93.8% Identity: 11% Fold: Cystatin-like Superfamily: NTF2-like Family: Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A Phyre2 PDB 2rfr chain A domain 1 Region: 262 - 308 Aligned: 47 Modelled: 47 Confidence: 93.7% Identity: 17% Fold: Cystatin-like Superfamily: NTF2-like Family: BaiE/LinA-like Phyre2 PDB 1idp chain A Region: 249 - 311 Aligned: 63 Modelled: 63 Confidence: 93.7% Identity: 11% Fold: Cystatin-like Superfamily: NTF2-like Family: Scytalone dehydratase Phyre2 1 c5u9oD_ 2 c4i4kB_ 3 d2ux0a1 4 c3wz4F_ 5 d1hkxa_ 6 c5d9rA_ 7 c5cnlA_ 8 d2r4ia1 9 d3d9ra1 10 c3gzrA_ 11 c3a76B_ 12 d3b8la1 13 c4ovmE_ 14 d3ebya1 15 c3wz3A_ 16 c3hx8A_ 17 d3cu3a1 18 d2f86b1 19 d2rfra1 20 d1idpa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99