1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	V	H	S	S	I	D	Q	H	P	D	L	L	A	L	R	A	S	F	D	R	A	A	E	S	T	I	A	H	F	T	F	G	L	A	L	L	A	G	L	Y	V	A	A	S	P	W	I	V	G	F	S	A	T	R	G	L	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?														?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	C	D	L	I	V	G	I	A	V	A	Y	L	A	Y	G	F	A	S	A	L	D	R	T	H	G	M	T	W	T	L	P	V	L	G	V	W	V	I	F	S	P	W	V	L	P	G	V	A	V	T	A	G	M	M	W	S	H	I	I
Secondary structure
SS confidence
Disorder																				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.
Sequence		A	G	A	V	V	A	V	L	G	F	Y	F	G	M	R	T	R	A	A	A	N	Q	G
Secondary structure
SS confidence
Disorder																?	?			?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 82%) Beta strand ( 0%) TM helix ( 52%) (View membrane topology prediction)

Rank Aligned region

PDB 1qgi chain A Region: 3 - 24 Aligned: 22 Modelled: 22 Confidence: 26.0% Identity: 41% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Chitosanase Phyre2 PDB 3klt chain B Region: 14 - 32 Aligned: 19 Modelled: 19 Confidence: 18.8% Identity: 16% PDB header:structural protein Chain: B: PDB Molecule:vimentin; PDBTitle: crystal structure of a vimentin fragment Phyre2 PDB 2yy0 chain D Region: 14 - 27 Aligned: 14 Modelled: 14 Confidence: 18.0% Identity: 14% PDB header:transcription Chain: D: PDB Molecule:c-myc-binding protein; PDBTitle: crystal structure of ms0802, c-myc-1 binding protein domain2 from homo sapiens Phyre2 PDB 6iu3 chain A Region: 29 - 108 Aligned: 79 Modelled: 80 Confidence: 16.5% Identity: 11% PDB header:metal transport Chain: A: PDB Molecule:vit1; PDBTitle: crystal structure of iron transporter vit1 with zinc ions Phyre2 PDB 2ks1 chain B Region: 108 - 137 Aligned: 30 Modelled: 30 Confidence: 12.6% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:epidermal growth factor receptor; PDBTitle: heterodimeric association of transmembrane domains of erbb1 and erbb22 receptors enabling kinase activation Phyre2 PDB 2imh chain A domain 1 Region: 8 - 34 Aligned: 27 Modelled: 27 Confidence: 12.5% Identity: 33% Fold: Ntn hydrolase-like Superfamily: N-terminal nucleophile aminohydrolases (Ntn hydrolases) Family: SPO2555-like Phyre2 PDB 4b1y chain M Region: 8 - 20 Aligned: 13 Modelled: 13 Confidence: 9.7% Identity: 31% PDB header:structural protein Chain: M: PDB Molecule:phosphatase and actin regulator 1; PDBTitle: structure of the phactr1 rpel-3 bound to g-actin Phyre2 PDB 2kmu chain A Region: 4 - 23 Aligned: 20 Modelled: 20 Confidence: 9.3% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:atp-dependent dna helicase q4; PDBTitle: recql4 amino-terminal domain Phyre2 PDB 4ph6 chain A Region: 4 - 26 Aligned: 23 Modelled: 23 Confidence: 9.2% Identity: 9% PDB header:lyase Chain: A: PDB Molecule:3-dehydroquinate dehydratase; PDBTitle: structure of 3-dehydroquinate dehydratase from enterococcus faecalis Phyre2 PDB 2imr chain A domain 1 Region: 9 - 28 Aligned: 18 Modelled: 20 Confidence: 9.1% Identity: 44% Fold: Composite domain of metallo-dependent hydrolases Superfamily: Composite domain of metallo-dependent hydrolases Family: DR0824-like Phyre2 PDB 5kbh chain B Region: 10 - 20 Aligned: 11 Modelled: 11 Confidence: 8.4% Identity: 27% PDB header:transcription Chain: B: PDB Molecule:mopr; PDBTitle: crystal structure of the aromatic sensor domain of mopr in complex2 with 3-chloro-phenol Phyre2 PDB 3js3 chain C Region: 4 - 26 Aligned: 23 Modelled: 23 Confidence: 8.3% Identity: 13% PDB header:lyase Chain: C: PDB Molecule:3-dehydroquinate dehydratase; PDBTitle: crystal structure of type i 3-dehydroquinate dehydratase (arod) from2 clostridium difficile with covalent reaction intermediate Phyre2 PDB 2yr1 chain B Region: 4 - 26 Aligned: 23 Modelled: 23 Confidence: 7.4% Identity: 22% PDB header:lyase Chain: B: PDB Molecule:3-dehydroquinate dehydratase; PDBTitle: crystal structure of 3-dehydroquinate dehydratase from geobacillus2 kaustophilus hta426 Phyre2 PDB 6b4g chain G Region: 66 - 111 Aligned: 45 Modelled: 46 Confidence: 7.2% Identity: 16% PDB header:transport protein Chain: G: PDB Molecule:nucleoporin gle1; PDBTitle: crystal structure of chaetomium thermophilum gle1 ctd-nup42 gbm2 complex Phyre2 PDB 3l2i chain B Region: 4 - 26 Aligned: 23 Modelled: 23 Confidence: 7.2% Identity: 9% PDB header:lyase Chain: B: PDB Molecule:3-dehydroquinate dehydratase; PDBTitle: 1.85 angstrom crystal structure of the 3-dehydroquinate dehydratase2 (arod) from salmonella typhimurium lt2. Phyre2 PDB 2mmu chain A Region: 32 - 85 Aligned: 48 Modelled: 54 Confidence: 7.1% Identity: 19% PDB header:cell cycle Chain: A: PDB Molecule:cell division protein crga; PDBTitle: structure of crga, a cell division structural and regulatory protein2 from mycobacterium tuberculosis, in lipid bilayers Phyre2 PDB 3odm chain E Region: 1 - 13 Aligned: 13 Modelled: 13 Confidence: 7.1% Identity: 46% PDB header:lyase Chain: E: PDB Molecule:phosphoenolpyruvate carboxylase; PDBTitle: archaeal-type phosphoenolpyruvate carboxylase Phyre2 PDB 1sfl chain A Region: 4 - 26 Aligned: 23 Modelled: 23 Confidence: 6.9% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: Class I aldolase Phyre2 PDB 3sjr chain B Region: 9 - 42 Aligned: 34 Modelled: 34 Confidence: 6.6% Identity: 29% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of conserved unkown function protein cv_1783 from2 chromobacterium violaceum atcc 12472 Phyre2 PDB 2vv5 chain A domain 3 Region: 18 - 80 Aligned: 55 Modelled: 63 Confidence: 6.5% Identity: 20% Fold: Mechanosensitive channel protein MscS (YggB), transmembrane region Superfamily: Mechanosensitive channel protein MscS (YggB), transmembrane region Family: Mechanosensitive channel protein MscS (YggB), transmembrane region Phyre2 1 d1qgia_ 2 c3kltB_ 3 c2yy0D_ 4 c6iu3A_ 5 c2ks1B_ 6 d2imha1 7 c4b1yM_ 8 c2kmuA_ 9 c4ph6A_ 10 d2imra1 11 c5kbhB_ 12 c3js3C_ 13 c2yr1B_ 14 c6b4gG_ 15 c3l2iB_ 16 c2mmuA_ 17 c3odmE_ 18 d1sfla_ 19 c3sjrB_ 20 d2vv5a3 21 22 23