1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	P	T	G	T	S	A	T	T	T	R	P	W	T	P	R	I	A	T	Q	L	S	V	L	A	C	A	A	F	I	Y	V	T	A	E	I	L	P	V	G	A	L	S	A	I	A	R	N	L	R	V	S	V	V	L	V	G	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	S	W	Y	A	L	V	A	A	V	T	T	V	P	L	V	R	W	T	A	H	W	P	R	R	R	A	L	V	V	S	L	V	C	L	T	V	S	Q	L	V	S	A	L	A	P	N	F	A	V	L	A	A	G	R	V	L	C	A
Secondary structure
SS confidence
Disorder																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	T	H	G	L	L	W	A	V	I	A	P	I	A	T	R	L	V	P	P	S	H	A	G	R	A	T	T	S	I	Y	I	G	T	S	L	A	L	V	V	G	S	P	L	T	A	A	M	S	L	M	W	G	W	R	L	A	A	V	C
Secondary structure
SS confidence
Disorder																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	T	G	A	A	A	A	V	A	L	A	A	R	L	A	L	P	E	M	V	L	R	A	D	Q	L	E	H	V	G	R	R	A	R	H	H	R	N	P	R	L	V	K	V	S	V	L	T	M	I	A	V	T	G	H	F	V	S	Y	T
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?	?	?	?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	I	V	V	I	I	R	D	V	V	G	V	R	G	P	N	L	A	W	L	L	A	A	Y	G	V	A	G	L	V	S	V	P	L	V	A	R	P	L	D	R	W	P	K	G	A	V	I	V	G	M	T	G	L	T	A	A	F	T	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	T	A	L	A	F	G	E	R	H	T	A	A	T	A	L	L	G	T	G	A	I	V	L	W	G	A	L	A	T	A	V	S	P	M	L	Q	S	A	A	M	R	S	G	G	D	D	P	D	G	A	S	G	L	Y	V	T	A	F	Q
Secondary structure
SS confidence
Disorder								?	?	?	?																																	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.
Sequence		I	G	I	M	A	G	A	L	L	G	G	L	L	Y	E	R	S	L	A	M	M	L	T	A	S	A	G	L	M	G	V	A	L	F	G	M	T	V	S	Q	H	L	F	E	N	P	T	L	S	P	G	D	G
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 65%) (View membrane topology prediction)

Rank Aligned region

PDB 6e9o chain A Region: 14 - 406 Aligned: 392 Modelled: 393 Confidence: 100.0% Identity: 11% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 4zp0 chain A Region: 16 - 402 Aligned: 387 Modelled: 387 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 2gfp chain A Region: 23 - 394 Aligned: 368 Modelled: 372 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 1pw4 chain A Region: 2 - 412 Aligned: 408 Modelled: 411 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 3wdo chain A Region: 12 - 407 Aligned: 391 Modelled: 396 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4lds chain B Region: 23 - 405 Aligned: 383 Modelled: 383 Confidence: 100.0% Identity: 14% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 6g9x chain B Region: 20 - 407 Aligned: 367 Modelled: 375 Confidence: 100.0% Identity: 16% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 4cl5 chain B Region: 10 - 409 Aligned: 400 Modelled: 400 Confidence: 100.0% Identity: 9% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 4aps chain B Region: 20 - 398 Aligned: 379 Modelled: 379 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 6exs chain A Region: 6 - 405 Aligned: 400 Modelled: 400 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 4iu8 chain A Region: 6 - 401 Aligned: 396 Modelled: 395 Confidence: 100.0% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter (selenomethionine2 derivative) Phyre2 PDB 4iu9 chain A Region: 3 - 401 Aligned: 390 Modelled: 399 Confidence: 100.0% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:nitrite extrusion protein 2; PDBTitle: crystal structure of a membrane transporter Phyre2 PDB 4iky chain A Region: 9 - 408 Aligned: 400 Modelled: 400 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 3o7p chain A Region: 17 - 404 Aligned: 383 Modelled: 388 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 4j05 chain A Region: 21 - 412 Aligned: 390 Modelled: 390 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 4w6v chain A Region: 5 - 405 Aligned: 398 Modelled: 401 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 6h7d chain A Region: 16 - 412 Aligned: 395 Modelled: 397 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 6gs7 chain A Region: 18 - 405 Aligned: 388 Modelled: 388 Confidence: 100.0% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4q65 chain A Region: 20 - 404 Aligned: 383 Modelled: 385 Confidence: 100.0% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:dipeptide permease d; PDBTitle: structure of the e. coli peptide transporter ybgh Phyre2 PDB 1pv7 chain B Region: 19 - 406 Aligned: 388 Modelled: 388 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:lactose permease; PDBTitle: crystal structure of lactose permease with tdg Phyre2 1 c6e9oA_ 2 c4zp0A_ 3 c2gfpA_ 4 d1pw4a_ 5 c3wdoA_ 6 c4ldsB_ 7 c6g9xB_ 8 c4cl5B_ 9 c4apsB_ 10 c6exsA_ 11 c4iu8A_ 12 c4iu9A_ 13 c4ikyA_ 14 c3o7pA_ 15 c4j05A_ 16 c4w6vA_ 17 c6h7dA_ 18 c6gs7A_ 19 c4q65A_ 20 c1pv7B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35