1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	L	A	I	P	S	G	I	D	L	S	H	I	D	A	D	A	R	P	Q	D	D	L	F	G	H	V	N	G	R	W	L	A	E	H	E	I	P	A	D	R	A	T	D	G	A	F	R	S	L	F	D	R	A	E	T	Q	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																														?		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	L	I	I	Q	A	S	Q	A	G	A	A	V	G	T	D	A	Q	R	I	G	D	L	Y	A	S	F	L	D	E	E	A	V	E	R	A	G	V	Q	P	L	H	D	E	L	A	T	I	D	S	A	A	D	A	T	E	L	A	A	A
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?																		?	?	?	?		?									?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	G	T	L	Q	R	A	G	V	G	G	G	I	G	V	Y	V	D	T	D	S	K	D	S	T	R	Y	L	V	H	F	T	Q	S	G	I	G	L	P	D	E	S	Y	Y	R	D	E	Q	H	A	A	V	L	A	A	Y	P	G	H	I
Secondary structure
SS confidence
Disorder																																			?	?	?								?	?				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	R	M	F	G	L	V	Y	G	G	E	S	R	D	H	A	K	T	A	D	R	I	V	A	L	E	T	K	L	A	D	A	H	W	D	V	V	K	R	R	D	A	D	L	G	Y	N	L	R	T	F	A	Q	L	Q	T	E	G	A	G
Secondary structure
SS confidence
Disorder																																		?		?				?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	D	W	V	S	W	V	T	A	L	G	S	A	P	D	A	M	T	E	L	V	V	R	Q	P	D	Y	L	V	T	F	A	S	L	W	A	S	V	N	V	E	D	W	K	C	W	A	R	W	R	L	I	R	A	R	A	P	W	L	T
Secondary structure
SS confidence
Disorder													?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		R	A	L	V	A	E	D	F	E	F	Y	G	R	T	L	T	G	A	Q	Q	L	R	D	R	W	K	R	G	V	S	L	V	E	N	L	M	G	D	A	V	G	K	L	Y	V	Q	R	H	F	P	P	D	A	K	S	R	I	D	T	L
Secondary structure
SS confidence
Disorder																	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	D	N	L	Q	E	A	Y	R	I	S	I	S	E	L	D	W	M	T	P	Q	T	R	Q	R	A	L	A	K	L	N	K	F	T	A	K	V	G	Y	P	I	K	W	R	D	Y	S	K	L	A	I	D	R	D	D	L	Y	G	N	V
Secondary structure
SS confidence
Disorder																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		Q	R	G	Y	A	V	N	H	D	R	E	L	A	K	L	F	G	P	V	D	R	D	E	W	F	M	T	P	Q	T	V	N	A	Y	Y	N	P	G	M	N	E	I	V	F	P	A	A	I	L	Q	P	P	F	F	D	P	Q	A	D	E
Secondary structure
SS confidence
Disorder																																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		A	A	N	Y	G	G	I	G	A	V	I	G	H	E	I	G	H	G	F	D	D	Q	G	A	K	Y	D	G	D	G	N	L	V	D	W	W	T	D	D	D	R	T	E	F	A	A	R	T	K	A	L	I	E	Q	Y	H	A	Y	T	P
Secondary structure
SS confidence
Disorder																													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		R	D	L	V	D	H	P	G	P	P	H	V	Q	G	A	F	T	I	G	E	N	I	G	D	L	G	G	L	S	I	A	L	L	A	Y	Q	L	S	L	N	G	N	P	A	P	V	I	D	G	L	T	G	M	Q	R	V	F	F	G	W
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?	?	?	?	?	?	?	?	?		?																						?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		A	Q	I	W	R	T	K	S	R	A	A	E	A	I	R	R	L	A	V	D	P	H	S	P	P	E	F	R	C	N	G	V	V	R	N	V	D	A	F	Y	Q	A	F	D	V	T	E	D	D	A	L	F	L	D	P	Q	R	R	V	R
Secondary structure
SS confidence
Disorder										?								?	?	?		?																												?	?	?		?	?					?	?
Disorder confidence
		.	.	.
Sequence		I	W	N
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 60%) Beta strand ( 5%) TM helix ( 2%) (View membrane topology prediction)

Rank Aligned region

PDB 3zuk chain B Region: 4 - 663 Aligned: 657 Modelled: 660 Confidence: 100.0% Identity: 100% PDB header:hydrolase/inhibitor Chain: B: PDB Molecule:endopeptidase, peptidase family m13; PDBTitle: crystal structure of mycobacterium tuberculosis zinc metalloprotease2 zmp1 in complex with inhibitor Phyre2 PDB 1dmt chain A Region: 7 - 662 Aligned: 645 Modelled: 652 Confidence: 100.0% Identity: 32% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Neutral endopeptidase (neprilysin) Phyre2 PDB 3dwb chain A Region: 7 - 662 Aligned: 633 Modelled: 655 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:endothelin-converting enzyme 1; PDBTitle: structure of human ece-1 complexed with phosphoramidon Phyre2 PDB 4iuw chain A Region: 19 - 663 Aligned: 623 Modelled: 636 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:neutral endopeptidase; PDBTitle: crystal structure of pepo from lactobacillus rhamnosis hn001 (dr20) Phyre2 PDB 1bsw chain A Region: 483 - 531 Aligned: 46 Modelled: 49 Confidence: 83.2% Identity: 22% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1wni chain A Region: 483 - 533 Aligned: 48 Modelled: 51 Confidence: 82.1% Identity: 19% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3k7l chain A Region: 482 - 529 Aligned: 45 Modelled: 45 Confidence: 82.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:atragin; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 2dw1 chain B Region: 483 - 529 Aligned: 44 Modelled: 44 Confidence: 67.2% Identity: 16% PDB header:apoptosis, toxin Chain: B: PDB Molecule:catrocollastatin; PDBTitle: crystal structure of vap2 from crotalus atrox venom (form 2-2 crystal) Phyre2 PDB 1r55 chain A Region: 483 - 511 Aligned: 26 Modelled: 29 Confidence: 66.0% Identity: 42% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1atl chain A Region: 483 - 510 Aligned: 25 Modelled: 28 Confidence: 66.0% Identity: 32% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1yp1 chain A Region: 483 - 533 Aligned: 48 Modelled: 51 Confidence: 64.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:fii; PDBTitle: crystal structure of a non-hemorrhagic fibrin(ogen)olytic2 metalloproteinase from venom of agkistrodon acutus Phyre2 PDB 1nd1 chain A Region: 483 - 510 Aligned: 25 Modelled: 28 Confidence: 64.9% Identity: 28% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 1kuf chain A Region: 483 - 529 Aligned: 44 Modelled: 47 Confidence: 62.5% Identity: 20% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 4dd8 chain B Region: 483 - 511 Aligned: 26 Modelled: 29 Confidence: 59.3% Identity: 31% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:disintegrin and metalloproteinase domain-containing protein PDBTitle: adam-8 metalloproteinase domain with bound batimastat Phyre2 PDB 6be6 chain D Region: 478 - 511 Aligned: 31 Modelled: 34 Confidence: 57.9% Identity: 23% PDB header:membrane protein Chain: D: PDB Molecule:disintegrin and metalloproteinase domain-containing protein PDBTitle: adam10 extracellular domain Phyre2 PDB 4aig chain A Region: 483 - 510 Aligned: 25 Modelled: 28 Confidence: 57.3% Identity: 28% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: Reprolysin-like Phyre2 PDB 3cqb chain B Region: 426 - 498 Aligned: 63 Modelled: 73 Confidence: 55.9% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:probable protease htpx homolog; PDBTitle: crystal structure of heat shock protein htpx domain from vibrio2 parahaemolyticus rimd 2210633 Phyre2 PDB 2i47 chain A domain 1 Region: 484 - 511 Aligned: 25 Modelled: 28 Confidence: 55.8% Identity: 44% Fold: Zincin-like Superfamily: Metalloproteases ("zincins"), catalytic domain Family: TNF-alpha converting enzyme, TACE, catalytic domain Phyre2 PDB 3k7n chain A Region: 482 - 530 Aligned: 46 Modelled: 46 Confidence: 54.5% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:k-like; PDBTitle: structures of two elapid snake venom metalloproteases with2 distinct activities highlight the disulfide patterns in the3 d domain of adamalysin family proteins Phyre2 PDB 2e3x chain A Region: 483 - 529 Aligned: 44 Modelled: 44 Confidence: 54.0% Identity: 14% PDB header:hydrolase, blood clotting, toxin Chain: A: PDB Molecule:coagulation factor x-activating enzyme heavy chain; PDBTitle: crystal structure of russell's viper venom metalloproteinase Phyre2 1 c3zukB_ 2 d1dmta_ 3 c3dwbA_ 4 c4iuwA_ 5 d1bswa_ 6 d1wnia_ 7 c3k7lA_ 8 c2dw1B_ 9 d1r55a_ 10 d1atla_ 11 c1yp1A_ 12 d1nd1a_ 13 d1kufa_ 14 c4dd8B_ 15 c6be6D_ 16 d4aiga_ 17 c3cqbB_ 18 d2i47a1 19 c3k7nA_ 20 c2e3xA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99