1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	S	L	D	D	A	S	V	A	P	L	V	R	K	T	A	A	W	A	W	R	F	L	V	I	L	A	A	M	V	A	L	L	W	V	L	N	K	F	E	V	I	V	V	P	V	L	L	A	L	M	L	S	A	L	L	V	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	V	D	W	L	D	S	R	G	L	P	H	A	V	A	V	T	L	V	L	L	S	G	F	A	V	L	G	G	I	L	T	F	V	V	S	Q	F	I	A	G	L	P	H	L	V	T	E	V	E	R	S	I	D	S	A	R	R	W	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	E	G	P	A	H	L	R	G	E	Q	I	D	N	A	G	N	A	A	I	E	A	L	R	N	N	Q	A	K	L	T	S	G	A	L	S	T	A	A	T	I	T	E	L	V	T	A	A	V	L	V	L	F	T	L	I	F	F	L	Y
Secondary structure
SS confidence
Disorder				?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	G	R	S	I	W	Q	Y	V	T	K	A	F	P	A	S	V	R	D	R	V	R	A	A	G	R	A	G	Y	A	S	L	I	G	Y	A	R	A	T	F	L	V	A	L	T	D	A	A	G	V	G	A	G	L	A	V	M	G	V	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	A	L	P	L	A	S	L	V	F	F	G	A	F	I	P	L	I	G	A	V	V	A	G	F	L	A	V	V	V	A	L	L	A	K	G	I	G	Y	A	L	I	T	V	G	L	L	I	A	V	N	Q	L	E	A	H	L	L	Q	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	V	M	G	R	A	V	S	I	H	P	L	A	V	V	L	A	I	A	A	G	G	V	L	A	G	V	V	G	A	L	L	A	V	P	T	V	A	F	F	N	N	A	V	Q	V	L	L	G	G	N	P	F	A	D	V	A	D	V	S
Secondary structure
SS confidence
Disorder					?	?		?																																														?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		S	D	H	L	T	E	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 84%) Beta strand ( 0%) TM helix ( 51%) (View membrane topology prediction)

Rank Aligned region

PDB 3x0u chain B Region: 240 - 270 Aligned: 31 Modelled: 31 Confidence: 42.6% Identity: 19% PDB header:toxin Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of pirb Phyre2 PDB 3zlj chain C Region: 3 - 24 Aligned: 20 Modelled: 20 Confidence: 36.1% Identity: 35% PDB header:dna binding protein/dna Chain: C: PDB Molecule:dna mismatch repair protein muts; PDBTitle: crystal structure of full-length e.coli dna mismatch repair protein2 muts d835r mutant in complex with gt mismatched dna Phyre2 PDB 3zlj chain D Region: 3 - 24 Aligned: 20 Modelled: 22 Confidence: 35.5% Identity: 35% PDB header:dna binding protein/dna Chain: D: PDB Molecule:dna mismatch repair protein muts; PDBTitle: crystal structure of full-length e.coli dna mismatch repair protein2 muts d835r mutant in complex with gt mismatched dna Phyre2 PDB 1ppj chain C domain 2 Region: 201 - 267 Aligned: 67 Modelled: 67 Confidence: 14.6% Identity: 15% Fold: Heme-binding four-helical bundle Superfamily: Transmembrane di-heme cytochromes Family: Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 2knc chain A Region: 304 - 364 Aligned: 50 Modelled: 61 Confidence: 11.8% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1kkx chain A Region: 300 - 365 Aligned: 66 Modelled: 66 Confidence: 11.5% Identity: 12% Fold: DNA/RNA-binding 3-helical bundle Superfamily: ARID-like Family: ARID domain Phyre2 PDB 6caa chain A Region: 277 - 366 Aligned: 89 Modelled: 90 Confidence: 11.5% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:electrogenic sodium bicarbonate cotransporter 1; PDBTitle: cryoem structure of human slc4a4 sodium-coupled acid-base transporter2 nbce1 Phyre2 PDB 6cb6 chain A Region: 174 - 224 Aligned: 44 Modelled: 51 Confidence: 10.8% Identity: 18% PDB header:viral protein Chain: A: PDB Molecule:protein a6; PDBTitle: crystal structure of vaccinia virus a6 n-terminus (space group c2) Phyre2 PDB 6hwh chain R Region: 329 - 366 Aligned: 38 Modelled: 38 Confidence: 10.2% Identity: 26% PDB header:electron transport Chain: R: PDB Molecule:msmeg_4693; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 1bcc chain C domain 3 Region: 201 - 266 Aligned: 66 Modelled: 66 Confidence: 9.1% Identity: 14% Fold: Heme-binding four-helical bundle Superfamily: Transmembrane di-heme cytochromes Family: Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) Phyre2 PDB 6adq chain I Region: 329 - 366 Aligned: 38 Modelled: 38 Confidence: 8.6% Identity: 26% PDB header:electron transport Chain: I: PDB Molecule:cytochrome c oxidase subunit ctaj; PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 3cwb chain C Region: 201 - 267 Aligned: 67 Modelled: 67 Confidence: 8.1% Identity: 13% PDB header:oxidoreductase Chain: C: PDB Molecule:cytochrome b; PDBTitle: chicken cytochrome bc1 complex inhibited by an iodinated analogue of2 the polyketide crocacin-d Phyre2 PDB 3j8b chain F Region: 304 - 315 Aligned: 12 Modelled: 12 Confidence: 7.9% Identity: 42% PDB header:translation Chain: F: PDB Molecule:eukaryotic translation initiation factor 3 subunit f; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s-hcv ires2 em map Phyre2 PDB 3j8c chain F Region: 304 - 315 Aligned: 12 Modelled: 12 Confidence: 7.9% Identity: 42% PDB header:translation Chain: F: PDB Molecule:eukaryotic translation initiation factor 3 subunit f; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s em map Phyre2 PDB 3j7k chain F Region: 304 - 315 Aligned: 12 Modelled: 12 Confidence: 7.9% Identity: 42% PDB header:translation Chain: F: PDB Molecule:eukaryotic translation initiation factor 3 subunit f; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s em map Phyre2 PDB 3j7j chain F Region: 304 - 315 Aligned: 12 Modelled: 12 Confidence: 7.9% Identity: 42% PDB header:translation Chain: F: PDB Molecule:eukaryotic translation initiation factor 3 subunit f; PDBTitle: model of the human eif3 pci-mpn octamer docked into the 43s-hcv ires2 em map Phyre2 PDB 5sv9 chain B Region: 171 - 251 Aligned: 79 Modelled: 81 Confidence: 7.3% Identity: 9% PDB header:transport protein Chain: B: PDB Molecule:bor1p boron transporter; PDBTitle: structure of the slc4 transporter bor1p in an inward-facing2 conformation Phyre2 PDB 6hu9 chain T Region: 320 - 338 Aligned: 19 Modelled: 19 Confidence: 7.3% Identity: 32% PDB header:oxidoreductase/electron transport Chain: T: PDB Molecule:cytochrome b-c1 complex subunit 9; PDBTitle: iii2-iv2 mitochondrial respiratory supercomplex from s. cerevisiae Phyre2 PDB 4j72 chain B Region: 45 - 89 Aligned: 45 Modelled: 45 Confidence: 7.1% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:phospho-n-acetylmuramoyl-pentapeptide-transferase; PDBTitle: crystal structure of polyprenyl-phosphate n-acetyl hexosamine 1-2 phosphate transferase Phyre2 PDB 2l8s chain A Region: 303 - 332 Aligned: 30 Modelled: 30 Confidence: 6.5% Identity: 23% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-1; PDBTitle: solution nmr structure of transmembrane and cytosolic regions of2 integrin alpha1 in detergent micelles Phyre2 1 c3x0uB_ 2 c3zljC_ 3 c3zljD_ 4 d1ppjc2 5 c2kncA_ 6 d1kkxa_ 7 c6caaA_ 8 c6cb6A_ 9 c6hwhR_ 10 d1bccc3 11 c6adqI_ 12 c3cwbC_ 13 c3j8bF_ 14 c3j8cF_ 15 c3j7kF_ 16 c3j7jF_ 17 c5sv9B_ 18 c6hu9t_ 19 c4j72B_ 20 c2l8sA_ 21 22 23 24 25 26 27 28 29