1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	D	I	A	T	R	F	K	N	S	Y	G	S	G	P	L	H	L	L	A	M	V	S	G	F	A	L	L	G	Y	I	V	A	T	A	R	P	S	A	L	W	N	Q	A	T	W	W	Q	S	I	A	V	W	F	V	A	A	V	V
Secondary structure
SS confidence
Disorder		?	?	?								?																							?	?	?		?	?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	H	D	L	L	L	Y	P	L	Y	A	L	A	D	R	I	L	A	R	L	V	G	R	R	D	V	S	A	P	R	R	R	P	E	L	P	V	R	N	Y	I	R	I	P	A	L	A	A	G	L	T	L	L	V	F	L	P	G	I	I
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	Q	G	A	P	T	Y	L	D	A	T	G	Q	T	Q	E	P	F	L	G	R	W	L	L	L	T	A	V	A	F	G	I	S	A	A	A	Y	A	I	R	L	V	V	A	H	V	R	R	R	R	A	G	C	S	R	V	D	A	I	D
Secondary structure
SS confidence
Disorder						?			?		?	?		?		?	?																												?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?
Disorder confidence
		.	.
Sequence		E	E
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 35%) (View membrane topology prediction)

Rank Aligned region

PDB 6gcs chain J Region: 108 - 129 Aligned: 20 Modelled: 22 Confidence: 24.9% Identity: 35% PDB header:oxidoreductase Chain: J: PDB Molecule:nujm subunit; PDBTitle: cryo-em structure of respiratory complex i from yarrowia lipolytica Phyre2 PDB 3wmm chain P Region: 49 - 65 Aligned: 17 Modelled: 17 Confidence: 17.8% Identity: 47% PDB header:photosynthesis Chain: P: PDB Molecule:lh1 beta polypeptide; PDBTitle: crystal structure of the lh1-rc complex from thermochromatium tepidum2 in c2 form Phyre2 PDB 4dzo chain A Region: 103 - 115 Aligned: 13 Modelled: 13 Confidence: 16.0% Identity: 54% PDB header:cell cycle Chain: A: PDB Molecule:mitotic spindle assembly checkpoint protein mad1; PDBTitle: structure of human mad1 c-terminal domain reveals its involvement in2 kinetochore targeting Phyre2 PDB 4rta chain B Region: 95 - 144 Aligned: 34 Modelled: 34 Confidence: 14.1% Identity: 47% PDB header:protein binding Chain: B: PDB Molecule:protein dpy-30 homolog; PDBTitle: cystal structure of the dpy30 for mll/set1 compass h3k4 trimethylation Phyre2 PDB 5m1h chain A Region: 4 - 20 Aligned: 17 Modelled: 17 Confidence: 11.6% Identity: 41% PDB header:viral protein Chain: A: PDB Molecule:gag protein; PDBTitle: structure of a spumaretrovirus gag central domain reveals an ancient2 retroviral capsid Phyre2 PDB 6hcy chain A Region: 64 - 164 Aligned: 98 Modelled: 101 Confidence: 10.0% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:metalloreductase steap4; PDBTitle: human steap4 bound to nadp, fad, heme and fe(iii)-nta. Phyre2 PDB 2eqf chain A Region: 8 - 16 Aligned: 9 Modelled: 9 Confidence: 9.8% Identity: 78% PDB header:hydrolase Chain: A: PDB Molecule:tumor necrosis factor, alpha-induced protein 3; PDBTitle: solution structure of the 7th a20-type zinc finger domain2 from human tumor necrosis factor, alpha-induced protein3 Phyre2 PDB 5d2m chain G Region: 90 - 101 Aligned: 12 Modelled: 12 Confidence: 7.5% Identity: 42% PDB header:ligase,protein binding Chain: G: PDB Molecule:zinc finger protein 451; PDBTitle: complex between human sumo2-rangap1, ubc9 and znf451 Phyre2 PDB 6j8l chain B Region: 134 - 143 Aligned: 10 Modelled: 10 Confidence: 7.4% Identity: 50% PDB header:immune system Chain: B: PDB Molecule:avh240; PDBTitle: phytophthora sojae effector psavh240 inhibits a host aspartic protease2 secretion to promote infection Phyre2 PDB 6bo5 chain D Region: 1 - 22 Aligned: 22 Modelled: 22 Confidence: 6.2% Identity: 23% PDB header:membrane protein Chain: D: PDB Molecule:transient receptor potential cation channel subfamily v PDBTitle: trpv2 ion channel in partially closed state Phyre2 1 c6gcsj_ 2 c3wmmP_ 3 c4dzoA_ 4 c4rtaB_ 5 c5m1hA_ 6 c6hcyA_ 7 c2eqfA_ 8 c5d2mG_ 9 c6j8lB_ 10 c6bo5D_