1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	R	F	A	A	C	G	A	I	G	L	G	A	A	L	L	I	A	A	L	L	L	S	T	Y	T	T	S	R	I	A	E	I	P	L	D	I	D	A	T	L	I	S	D	G	T	G	T	A	L	D	S	A	S	L	A	T	E	H
Secondary structure
SS confidence
Disorder		?	?	?	?																																																				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	V	V	N	Q	D	V	P	L	V	S	Q	Q	Q	V	T	V	E	S	P	A	N	A	D	V	V	T	L	Q	V	G	S	S	L	R	R	T	D	K	Q	K	D	S	G	L	L	L	A	I	V	D	T	V	T	L	N	R	K	T	A
Secondary structure
SS confidence
Disorder			?	?	?	?												?		?	?																	?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	A	V	S	D	D	T	H	T	G	G	A	V	Q	K	P	R	G	L	N	D	E	N	P	P	T	A	I	P	L	R	H	D	G	L	S	Y	R	F	P	F	H	T	E	K	K	T	Y	P	Y	F	D	P	I	A	Q	K	A	F	D
Secondary structure
SS confidence
Disorder											?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	N	Y	E	G	E	E	D	V	N	G	L	T	T	Y	R	F	T	Q	N	V	G	Y	T	P	E	G	K	L	V	A	P	L	K	Y	P	S	L	Y	A	G	D	E	D	G	K	V	T	T	S	A	A	M	W	G	L	P	G	D	P
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	E	Q	I	T	M	T	R	Y	Y	A	A	Q	R	T	F	W	V	D	P	V	S	G	T	I	V	K	E	T	E	R	A	N	H	Y	F	A	R	D	P	L	K	P	E	V	T	F	A	D	Y	Q	V	T	S	T	E	E	T	V	E
Secondary structure
SS confidence
Disorder		?																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	Q	V	N	A	A	R	D	E	R	D	R	L	A	L	W	S	R	V	L	P	I	T	F	T	A	A	G	L	V	A	L	V	G	G	G	L	F	A	S	F	S	L	R	T	E	G	A	L	M	A	A	S	G	D	R	D	D	H	D
Secondary structure
SS confidence
Disorder																																								?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Y	R	R	G	G	F	E	E	P	V	P	G	A	E	A	E	T	E	K	L	P	T	Q	R	P	D	F	P	R	E	P	S	G	S	D	P	P	R	L	G	S	A	Q	P	P	P	P	P	D	A	G	H	P	D	P	G	P	P	E	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?			?	?	?	?	?		?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.
Sequence		R
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 37%) Alpha helix ( 19%) Beta strand ( 25%) TM helix ( 10%) (View membrane topology prediction)

Rank Aligned region

PDB 4qa8 chain A Region: 153 - 293 Aligned: 108 Modelled: 109 Confidence: 97.1% Identity: 16% PDB header:lipid transport Chain: A: PDB Molecule:putative lipoprotein lprf; PDBTitle: crystal structure of lprf from mycobacterium bovis Phyre2 PDB 3mha chain B Region: 154 - 249 Aligned: 71 Modelled: 71 Confidence: 95.6% Identity: 21% PDB header:lipid binding protein Chain: B: PDB Molecule:lipoprotein lprg; PDBTitle: crystal structure of lprg from mycobacterium tuberculosis bound to pim Phyre2 PDB 4f7b chain A Region: 160 - 198 Aligned: 39 Modelled: 39 Confidence: 94.8% Identity: 21% PDB header:cell adhesion Chain: A: PDB Molecule:lysosome membrane protein 2; PDBTitle: structure of the lysosomal domain of limp-2 Phyre2 PDB 2byo chain A domain 1 Region: 175 - 265 Aligned: 64 Modelled: 64 Confidence: 94.3% Identity: 23% Fold: LolA-like prokaryotic lipoproteins and lipoprotein localization factors Superfamily: Prokaryotic lipoproteins and lipoprotein localization factors Family: LppX-like Phyre2 PDB 5lgd chain A Region: 158 - 198 Aligned: 41 Modelled: 41 Confidence: 93.9% Identity: 27% PDB header:cell adhesion Chain: A: PDB Molecule:platelet glycoprotein 4; PDBTitle: the cidra domain from mcvar1 pfemp1 bound to cd36 Phyre2 PDB 2v43 chain A Region: 175 - 269 Aligned: 50 Modelled: 50 Confidence: 90.3% Identity: 20% PDB header:regulator Chain: A: PDB Molecule:sigma-e factor regulatory protein rseb; PDBTitle: crystal structure of rseb: a sensor for periplasmic stress2 response in e. coli Phyre2 PDB 3bk5 chain A Region: 182 - 269 Aligned: 45 Modelled: 46 Confidence: 90.0% Identity: 31% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative outer membrane lipoprotein-sorting protein; PDBTitle: crystal structure of putative outer membrane lipoprotein-sorting2 protein domain from vibrio parahaemolyticus Phyre2 PDB 3buu chain B Region: 181 - 269 Aligned: 46 Modelled: 47 Confidence: 89.8% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized lola superfamily protein ne2245; PDBTitle: crystal structure of lola superfamily protein ne2245 from2 nitrosomonas europaea Phyre2 PDB 4z48 chain B Region: 181 - 269 Aligned: 46 Modelled: 46 Confidence: 86.7% Identity: 22% PDB header:structural biology, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a duf1329 family protein (despig_00262) from2 desulfovibrio piger atcc 29098 at 1.75 a resolution Phyre2 PDB 2in5 chain A domain 1 Region: 250 - 289 Aligned: 36 Modelled: 40 Confidence: 76.1% Identity: 28% Fold: YmcC-like Superfamily: YmcC-like Family: YmcC-like Phyre2 PDB 6et5 chain B Region: 8 - 32 Aligned: 25 Modelled: 25 Confidence: 59.3% Identity: 24% PDB header:photosynthesis Chain: B: PDB Molecule: PDBTitle: reaction centre light harvesting complex 1 from blc. virids Phyre2 PDB 1xrd chain A Region: 8 - 23 Aligned: 16 Modelled: 16 Confidence: 57.6% Identity: 38% PDB header:membrane protein Chain: A: PDB Molecule:light-harvesting protein b-880, alpha chain; PDBTitle: light-harvesting complex 1 alfa subunit from wild-type2 rhodospirillum rubrum Phyre2 PDB 1xrd chain A domain 1 Region: 8 - 23 Aligned: 16 Modelled: 16 Confidence: 57.6% Identity: 38% Fold: Light-harvesting complex subunits Superfamily: Light-harvesting complex subunits Family: Light-harvesting complex subunits Phyre2 PDB 3wmm chain Y Region: 8 - 23 Aligned: 16 Modelled: 16 Confidence: 57.6% Identity: 19% PDB header:photosynthesis Chain: Y: PDB Molecule:lh1 alpha polypeptide; PDBTitle: crystal structure of the lh1-rc complex from thermochromatium tepidum2 in c2 form Phyre2 PDB 2knc chain B Region: 320 - 338 Aligned: 19 Modelled: 19 Confidence: 52.6% Identity: 21% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2klu chain A Region: 322 - 351 Aligned: 30 Modelled: 30 Confidence: 43.4% Identity: 13% PDB header:immune system, membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd4; PDBTitle: nmr structure of the transmembrane and cytoplasmic domains2 of human cd4 Phyre2 PDB 2n2a chain A Region: 321 - 344 Aligned: 24 Modelled: 24 Confidence: 41.8% Identity: 25% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: spatial structure of her2/erbb2 dimeric transmembrane domain in the2 presence of cytoplasmic juxtamembrane domains Phyre2 PDB 6cfw chain E Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 37.4% Identity: 25% PDB header:membrane protein Chain: E: PDB Molecule:mbh subunit; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 6f0k chain A Region: 3 - 41 Aligned: 39 Modelled: 39 Confidence: 28.0% Identity: 18% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c family protein; PDBTitle: alternative complex iii Phyre2 PDB 5yan chain E Region: 352 - 369 Aligned: 18 Modelled: 18 Confidence: 27.8% Identity: 28% PDB header:structural protein Chain: E: PDB Molecule:collagen; PDBTitle: deconstructing the salt-bridge network of a computationally designed2 collagen heterotrimer Phyre2 1 c4qa8A_ 2 c3mhaB_ 3 c4f7bA_ 4 d2byoa1 5 c5lgdA_ 6 c2v43A_ 7 c3bk5A_ 8 c3buuB_ 9 c4z48B_ 10 d2in5a1 11 c6et5b_ 12 c1xrdA_ 13 d1xrda1 14 c3wmmY_ 15 c2kncB_ 16 c2kluA_ 17 c2n2aA_ 18 c6cfwE_ 19 c6f0kA_ 20 c5yanE_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99