1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	P	A	D	E	S	G	A	P	I	R	P	Q	T	P	H	R	H	T	V	L	V	T	N	G	Q	V	V	G	G	T	R	G	F	L	P	A	V	E	G	M	R	A	C	A	A	V	G	V	V	V	T	H	V	A	F	Q	T	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	S	S	G	V	G	G	R	L	F	G	R	F	D	L	A	V	A	V	F	F	A	V	S	G	F	L	L	W	R	G	H	A	A	A	A	R	D	L	R	S	H	P	R	T	G	P	Y	L	R	S	R	V	A	R	I	M	P	A	Y
Secondary structure
SS confidence
Disorder		?	?		?																																	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	A	V	V	V	I	L	S	L	L	P	D	A	D	H	A	S	L	T	V	W	L	A	N	L	T	L	T	Q	I	Y	V	P	L	T	L	T	G	G	L	T	Q	M	W	S	L	S	V	E	V	A	F	Y	A	A	L	P	V	L
Secondary structure
SS confidence
Disorder															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	L	L	G	R	R	I	P	V	G	A	R	V	P	A	I	A	A	L	A	A	L	S	W	A	W	G	W	L	P	L	D	A	G	S	G	I	N	P	L	T	W	P	P	A	F	F	S	W	F	A	A	G	M	L	L	A	E	W	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	S	P	V	G	L	P	H	R	W	A	R	R	R	V	A	M	A	V	T	A	L	L	G	Y	L	V	A	A	S	P	L	A	G	P	E	G	L	V	P	G	T	A	A	Q	F	A	V	K	T	A	M	G	S	L	V	A	F	A	L
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	A	P	L	V	L	D	R	P	D	T	S	H	R	L	L	G	S	P	A	M	V	T	L	G	R	W	S	Y	G	L	F	I	W	H	L	A	A	L	A	M	V	F	P	V	I	G	A	F	P	F	T	G	R	M	P	T	V	L	V
Secondary structure
SS confidence
Disorder								?																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.
Sequence		L	T	L	I	F	G	F	A	I	A	A	V	S	Y	A	L	V	E	S	P	C	R	E	A	L	R	R	W	E	R	R	N	E	P	I	S	V	G	E	L	Q	A	D	A	I	A	P
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 22%) Alpha helix ( 68%) Beta strand ( 0%) TM helix ( 29%) (View membrane topology prediction)

Rank Aligned region

PDB 4dji chain A Region: 242 - 407 Aligned: 166 Modelled: 166 Confidence: 50.3% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 6cfw chain I Region: 356 - 407 Aligned: 50 Modelled: 52 Confidence: 39.9% Identity: 14% PDB header:membrane protein Chain: I: PDB Molecule:mbh subunit; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 2knc chain A Region: 346 - 404 Aligned: 52 Modelled: 59 Confidence: 32.0% Identity: 17% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 6mjp chain F Region: 287 - 391 Aligned: 98 Modelled: 100 Confidence: 23.6% Identity: 12% PDB header:lipid transport Chain: F: PDB Molecule:fig000988: predicted permease; PDBTitle: lptb(e163q)fgc from vibrio cholerae Phyre2 PDB 1y6i chain A domain 2 Region: 33 - 54 Aligned: 22 Modelled: 22 Confidence: 22.0% Identity: 23% Fold: GUN4-like Superfamily: GUN4-like Family: GUN4-like Phyre2 PDB 2wwb chain B Region: 321 - 338 Aligned: 18 Modelled: 18 Confidence: 20.2% Identity: 11% PDB header:ribosome Chain: B: PDB Molecule:protein transport protein sec61 subunit gamma; PDBTitle: cryo-em structure of the mammalian sec61 complex bound to the actively2 translating wheat germ 80s ribosome Phyre2 PDB 1f8v chain A Region: 1 - 43 Aligned: 37 Modelled: 43 Confidence: 20.0% Identity: 22% PDB header:virus/rna Chain: A: PDB Molecule:mature capsid protein beta; PDBTitle: the structure of pariacoto virus reveals a dodecahedral cage of duplex2 rna Phyre2 PDB 2f9j chain P Region: 378 - 402 Aligned: 25 Modelled: 25 Confidence: 19.1% Identity: 32% PDB header:rna binding protein Chain: P: PDB Molecule:splicing factor 3b subunit 1; PDBTitle: 3.0 angstrom resolution structure of a y22m mutant of the spliceosomal2 protein p14 bound to a region of sf3b155 Phyre2 PDB 4gn0 chain D Region: 355 - 386 Aligned: 32 Modelled: 32 Confidence: 12.1% Identity: 9% PDB header:signaling protein Chain: D: PDB Molecule:hamp domain of af1503; PDBTitle: de novo phasing of a hamp-complex using an improved arcimboldo method Phyre2 PDB 2oar chain A domain 1 Region: 358 - 399 Aligned: 42 Modelled: 42 Confidence: 11.9% Identity: 26% Fold: Gated mechanosensitive channel Superfamily: Gated mechanosensitive channel Family: Gated mechanosensitive channel Phyre2 PDB 2oar chain A Region: 358 - 399 Aligned: 42 Modelled: 42 Confidence: 10.3% Identity: 26% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: mechanosensitive channel of large conductance (mscl) Phyre2 PDB 1rhz chain B Region: 321 - 338 Aligned: 18 Modelled: 18 Confidence: 8.5% Identity: 17% Fold: Single transmembrane helix Superfamily: Preprotein translocase SecE subunit Family: Preprotein translocase SecE subunit Phyre2 PDB 5jef chain A Region: 355 - 386 Aligned: 32 Modelled: 32 Confidence: 8.4% Identity: 9% PDB header:transferase Chain: A: PDB Molecule:nitrate/nitrite sensor protein narq; PDBTitle: fragment of nitrate/nitrite sensor histidine kinase narq (wt) in2 asymmetric holo state Phyre2 PDB 2k1a chain A Region: 354 - 394 Aligned: 34 Modelled: 41 Confidence: 7.1% Identity: 24% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: bicelle-embedded integrin alpha(iib) transmembrane segment Phyre2 PDB 3ayg chain A Region: 40 - 401 Aligned: 344 Modelled: 362 Confidence: 6.5% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:nitric oxide reductase; PDBTitle: crystal structure of nitric oxide reductase complex with hqno Phyre2 PDB 1z3x chain A domain 2 Region: 33 - 54 Aligned: 22 Modelled: 22 Confidence: 6.0% Identity: 27% Fold: GUN4-like Superfamily: GUN4-like Family: GUN4-like Phyre2 PDB 1w6k chain A domain 2 Region: 81 - 112 Aligned: 32 Modelled: 32 Confidence: 5.5% Identity: 25% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Terpene synthases Phyre2 PDB 2kog chain A Region: 2 - 47 Aligned: 39 Modelled: 46 Confidence: 5.3% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:vesicle-associated membrane protein 2; PDBTitle: lipid-bound synaptobrevin solution nmr structure Phyre2 1 c4djiA_ 2 c6cfwI_ 3 c2kncA_ 4 c6mjpF_ 5 d1y6ia2 6 c2wwbB_ 7 c1f8vA_ 8 c2f9jP_ 9 c4gn0D_ 10 d2oara1 11 c2oarA_ 12 d1rhzb_ 13 c5jefA_ 14 c2k1aA_ 15 c3aygA_ 16 d1z3xa2 17 d1w6ka2 18 c2kogA_