1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	P	E	L	N	T	A	R	G	P	I	D	T	A	D	L	G	V	T	L	M	H	E	H	V	F	I	M	T	T	E	I	A	Q	N	Y	P	E	A	W	G	D	E	D	K	R	V	A	G	A	I	A	R	L	G	E	L	K	A	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	D	T	I	V	D	L	T	V	I	G	L	G	R	Y	I	P	R	I	A	R	V	A	A	A	T	E	L	N	I	V	V	A	T	G	L	Y	T	Y	N	D	V	P	F	Y	F	H	Y	L	G	P	G	A	Q	L	D	G	P	E
Secondary structure
SS confidence
Disorder																																																					?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	M	T	D	M	F	V	R	D	I	E	H	G	I	A	D	T	G	I	K	A	G	I	L	K	C	A	T	D	E	P	G	L	T	P	G	V	E	R	V	L	R	A	V	A	Q	A	H	K	R	T	G	A	P	I	S	T	H	T	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	G	L	R	R	G	L	D	Q	Q	R	I	F	A	E	E	G	V	D	L	S	R	V	V	I	G	H	C	G	D	S	T	D	V	G	Y	L	E	E	L	I	A	A	G	S	Y	L	G	M	D	R	F	G	V	D	V	I	S	P	F
Secondary structure
SS confidence
Disorder						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	D	R	V	N	I	V	A	R	M	C	E	R	G	H	A	D	K	M	V	L	S	H	D	A	C	C	Y	F	D	A	L	P	E	E	L	V	P	V	A	M	P	N	W	H	Y	L	H	I	H	N	D	V	I	P	A	L	K	Q	H
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.
Sequence		G	V	T	D	E	Q	L	H	T	M	L	V	D	N	P	R	R	I	F	E	R	Q	G	G	Y	Q
Secondary structure
SS confidence
Disorder																					?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 40%) Beta strand ( 13%)

Rank Aligned region

PDB 4if2 chain A Region: 2 - 325 Aligned: 323 Modelled: 324 Confidence: 100.0% Identity: 100% PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase homology protein; PDBTitle: structure of the phosphotriesterase from mycobacterium tuberculosis Phyre2 PDB 3k2g chain A Region: 3 - 322 Aligned: 306 Modelled: 320 Confidence: 100.0% Identity: 28% PDB header:resiniferatoxin binding protein Chain: A: PDB Molecule:resiniferatoxin-binding, phosphotriesterase- PDBTitle: crystal structure of a resiniferatoxin-binding protein from2 rhodobacter sphaeroides Phyre2 PDB 1i0d chain A Region: 2 - 322 Aligned: 311 Modelled: 312 Confidence: 100.0% Identity: 36% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Phosphotriesterase-like Phyre2 PDB 2d2j chain A domain 1 Region: 2 - 320 Aligned: 309 Modelled: 310 Confidence: 100.0% Identity: 37% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Phosphotriesterase-like Phyre2 PDB 2zc1 chain A Region: 4 - 320 Aligned: 314 Modelled: 316 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: organophosphorus hydrolase from deinococcus radiodurans Phyre2 PDB 3tn6 chain A Region: 2 - 320 Aligned: 316 Modelled: 318 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: crystal structure of gkap mutant r230h from geobacillus kaustophilus2 hta426 Phyre2 PDB 3f4c chain A Region: 3 - 320 Aligned: 315 Modelled: 317 Confidence: 100.0% Identity: 34% PDB header:hydrolase Chain: A: PDB Molecule:organophosphorus hydrolase; PDBTitle: crystal structure of organophosphorus hydrolase from geobacillus2 stearothermophilus strain 10, with glycerol bound Phyre2 PDB 3rhg chain A Region: 4 - 325 Aligned: 307 Modelled: 322 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:putative phophotriesterase; PDBTitle: crystal structure of amidohydrolase pmi1525 (target efi-500319) from2 proteus mirabilis hi4320 Phyre2 PDB 3pnz chain D Region: 4 - 322 Aligned: 313 Modelled: 319 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: D: PDB Molecule:phosphotriesterase family protein; PDBTitle: crystal structure of the lactonase lmo2620 from listeria monocytogenes Phyre2 PDB 1psc chain A Region: 2 - 322 Aligned: 311 Modelled: 311 Confidence: 100.0% Identity: 36% PDB header:hydrolase Chain: A: PDB Molecule:phosphotriesterase; PDBTitle: phosphotriesterase from pseudomonas diminuta Phyre2 PDB 4rdz chain A Region: 4 - 319 Aligned: 307 Modelled: 316 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:parathion hydrolase; PDBTitle: crystal structure of vmolac in p64 space group Phyre2 PDB 2vc7 chain A Region: 8 - 320 Aligned: 304 Modelled: 313 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:aryldialkylphosphatase; PDBTitle: structural basis for natural lactonase and promiscuous2 phosphotriesterase activities Phyre2 PDB 1bf6 chain A Region: 14 - 319 Aligned: 287 Modelled: 302 Confidence: 100.0% Identity: 31% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Phosphotriesterase-like Phyre2 PDB 3msr chain A Region: 2 - 324 Aligned: 319 Modelled: 323 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolases; PDBTitle: the crystal structure of an amidohydrolase from mycoplasma synoviae Phyre2 PDB 3e2v chain A Region: 18 - 320 Aligned: 288 Modelled: 297 Confidence: 99.9% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:3'-5'-exonuclease; PDBTitle: crystal structure of an uncharacterized amidohydrolase from2 saccharomyces cerevisiae Phyre2 PDB 2xio chain A Region: 16 - 319 Aligned: 269 Modelled: 291 Confidence: 99.9% Identity: 10% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn1; PDBTitle: structure of putative deoxyribonuclease tatdn1 isoform a Phyre2 PDB 3ipw chain A Region: 18 - 319 Aligned: 265 Modelled: 280 Confidence: 99.9% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase tatd family protein; PDBTitle: crystal structure of hydrolase tatd family protein from entamoeba2 histolytica Phyre2 PDB 2y1h chain A Region: 15 - 321 Aligned: 255 Modelled: 291 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyribonuclease tatdn3; PDBTitle: crystal structure of the human tatd-domain protein 3 (tatdn3) Phyre2 PDB 1zzm chain A domain 1 Region: 18 - 322 Aligned: 254 Modelled: 275 Confidence: 99.9% Identity: 13% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 PDB 1xwy chain A domain 1 Region: 18 - 322 Aligned: 258 Modelled: 272 Confidence: 99.9% Identity: 14% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 1 c4if2A_ 2 c3k2gA_ 3 d1i0da_ 4 d2d2ja1 5 c2zc1A_ 6 c3tn6A_ 7 c3f4cA_ 8 c3rhgA_ 9 c3pnzD_ 10 c1pscA_ 11 c4rdzA_ 12 c2vc7A_ 13 d1bf6a_ 14 c3msrA_ 15 c3e2vA_ 16 c2xioA_ 17 c3ipwA_ 18 c2y1hA_ 19 d1zzma1 20 d1xwya1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225