1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	R	T	R	S	G	S	L	A	A	G	G	L	N	W	A	S	L	P	L	K	L	F	A	G	G	N	A	K	F	W	H	P	A	D	I	D	F	T	R	D	R	A	D	W	E	K	L	S	D	D	E	R	D	Y	A	T	R	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?		?																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		C	T	Q	F	I	A	G	E	E	A	V	T	E	D	I	Q	P	F	M	S	A	M	R	A	E	G	R	L	A	D	E	M	Y	L	T	Q	F	A	F	E	E	A	K	H	T	Q	V	F	R	M	W	L	D	A	V	G	I	S	E	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	H	R	Y	L	D	D	L	P	A	Y	R	Q	I	F	Y	A	E	L	P	E	C	L	N	A	L	S	A	D	P	S	P	A	A	Q	V	R	A	S	V	T	Y	N	H	I	V	E	G	M	L	A	L	T	G	Y	Y	A	W	H	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	C	V	E	R	A	I	L	P	G	M	Q	E	L	V	R	R	I	G	D	D	E	R	R	H	M	A	W	G	T	F	T	C	R	R	H	V	A	A	D	D	A	N	W	T	V	F	E	T	R	M	N	E	L	I	P	L	A	L	R
Secondary structure
SS confidence
Disorder																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	I	E	E	G	F	A	L	Y	G	D	Q	P	P	F	D	L	S	K	D	D	F	L	Q	Y	S	T	D	K	G	M	R	R	F	G	T	I	S	N	A	R	G	R	P	V	A	E	I	D	V	D	Y	S	P	A	Q	L	E	D	T
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?		?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.
Sequence		F	A	D	E	D	R	R	T	L	A	A	A	S	A
Secondary structure
SS confidence
Disorder												?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 7%) Alpha helix ( 79%) Beta strand ( 0%) TM helix ( 7%) (View membrane topology prediction)

Rank Aligned region

PDB 3ee4 chain A Region: 2 - 290 Aligned: 289 Modelled: 289 Confidence: 100.0% Identity: 100% PDB header:oxidoreductase Chain: A: PDB Molecule:probable ribonucleoside-diphosphate reductase; PDBTitle: r2-like ligand binding mn/fe oxidase from m. tuberculosis Phyre2 PDB 2rcc chain C Region: 2 - 289 Aligned: 282 Modelled: 288 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: C: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of putative class i ribonucleotide reductase2 (np_241368.1) from bacillus halodurans at 1.90 a resolution Phyre2 PDB 1yfd chain A Region: 2 - 289 Aligned: 282 Modelled: 288 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase 1 beta chain; PDBTitle: crystal structure of the y122h mutant of ribonucleotide reductase r22 protein from e. coli Phyre2 PDB 4bmt chain B Region: 13 - 288 Aligned: 273 Modelled: 276 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of ribonucleotide reductase di-iron nrdf2 from bacillus cereus Phyre2 PDB 6cwq chain A Region: 8 - 304 Aligned: 288 Modelled: 294 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleotide reductase; PDBTitle: x-ray crystal structure of flavobacterium johnsoniae dimanganese(ii)2 ribonucleotide reductase beta subunit (as-isolated) Phyre2 PDB 1mxr chain A Region: 3 - 289 Aligned: 281 Modelled: 287 Confidence: 100.0% Identity: 18% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4hr0 chain A Region: 1 - 281 Aligned: 279 Modelled: 280 Confidence: 100.0% Identity: 34% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonuleotide reductase small subunit; PDBTitle: r2-like ligand-binding oxidase with aerobically reconstituted metal2 cofactor Phyre2 PDB 1r2f chain A Region: 12 - 294 Aligned: 274 Modelled: 283 Confidence: 100.0% Identity: 17% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 5olk chain D Region: 5 - 295 Aligned: 282 Modelled: 291 Confidence: 100.0% Identity: 16% PDB header:oxidoreductase Chain: D: PDB Molecule:ribonucleoside-diphosphate reductase, beta subunit 1; PDBTitle: crystal structure of the atp-cone-containing nrdb from2 leeuwenhoekiella blandensis Phyre2 PDB 1jk0 chain A Region: 9 - 289 Aligned: 268 Modelled: 268 Confidence: 100.0% Identity: 15% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1uzr chain A Region: 10 - 288 Aligned: 270 Modelled: 279 Confidence: 100.0% Identity: 17% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1sms chain A Region: 6 - 311 Aligned: 282 Modelled: 303 Confidence: 100.0% Identity: 15% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1r2f chain B Region: 12 - 290 Aligned: 270 Modelled: 279 Confidence: 100.0% Identity: 15% PDB header:oxidoreductase Chain: B: PDB Molecule:protein (ribonucleotide reductase r2); PDBTitle: ribonucleotide reductase r2f protein from salmonella2 typhimurium Phyre2 PDB 1syy chain A Region: 3 - 288 Aligned: 280 Modelled: 286 Confidence: 100.0% Identity: 22% PDB header:replication,oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase beta chain; PDBTitle: crystal structure of the r2 subunit of ribonucleotide reductase from2 chlamydia trachomatis Phyre2 PDB 1syy chain A Region: 3 - 288 Aligned: 280 Modelled: 286 Confidence: 100.0% Identity: 22% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1oqu chain C Region: 13 - 301 Aligned: 278 Modelled: 287 Confidence: 100.0% Identity: 16% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 4n83 chain F Region: 13 - 289 Aligned: 268 Modelled: 277 Confidence: 100.0% Identity: 13% PDB header:oxidoreductase Chain: F: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: x-ray crystal structure of streptococcus sanguinis dimanganese(ii)-2 nrdf Phyre2 PDB 4dr0 chain A Region: 13 - 288 Aligned: 272 Modelled: 276 Confidence: 100.0% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase subunit beta; PDBTitle: crystal structure of bacillus subtilis dimanganese(ii) nrdf Phyre2 PDB 3dhz chain A domain 1 Region: 12 - 289 Aligned: 269 Modelled: 278 Confidence: 100.0% Identity: 16% Fold: Ferritin-like Superfamily: Ferritin-like Family: Ribonucleotide reductase-like Phyre2 PDB 1h0o chain A Region: 9 - 289 Aligned: 268 Modelled: 273 Confidence: 100.0% Identity: 18% PDB header:oxidoreductase Chain: A: PDB Molecule:ribonucleoside-diphosphate reductase; PDBTitle: cobalt substitution of mouse r2 ribonucleotide reductase to2 model the reactive diferrous state Phyre2 1 c3ee4A_ 2 c2rccC_ 3 c1yfdA_ 4 c4bmtB_ 5 c6cwqA_ 6 d1mxra_ 7 c4hr0A_ 8 d1r2fa_ 9 c5olkD_ 10 d1jk0a_ 11 d1uzra_ 12 d1smsa_ 13 c1r2fB_ 14 c1syyA_ 15 d1syya_ 16 d1oquc_ 17 c4n83F_ 18 c4dr0A_ 19 d3dhza1 20 c1h0oA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102