1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	W	F	S	A	P	E	Y	W	L	G	R	L	A	L	E	R	G	T	A	I	I	Y	L	I	A	F	V	A	A	A	Q	Q	F	R	P	L	I	G	E	H	G	M	L	P	V	P	R	Y	L	A	G	Q	S	F	W	R	T	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	I	F	H	F	R	Y	S	D	R	V	F	A	G	V	C	W	L	G	A	V	L	S	A	A	V	V	A	G	A	A	S	F	V	P	L	W	A	T	M	L	I	W	L	T	L	W	V	L	Y	L	S	I	V	N	V	G	Q	A	W
Secondary structure
SS confidence
Disorder																																		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Y	S	F	G	W	E	S	L	L	L	E	T	G	F	L	M	I	F	L	G	N	E	R	T	A	P	P	I	L	T	L	L	L	A	R	W	L	L	F	R	V	E	F	G	A	G	L	I	K	M	R	G	D	S	C	W	R	S	L	T
Secondary structure
SS confidence
Disorder																								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		C	L	Y	Y	H	H	E	T	Q	P	M	P	G	P	L	S	W	F	F	H	H	L	P	K	P	L	H	R	I	E	V	A	G	N	H	F	A	Q	L	V	V	P	F	G	L	F	T	P	Q	P	A	A	S	I	A	A	A	I	I	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	T	Q	L	W	L	V	A	S	G	N	F	S	W	L	N	W	L	T	I	L	L	A	C	S	A	I	D	T	S	S	A	A	A	L	L	P	M	P	A	Q	P	A	L	S	A	P	P	Q	W	F	A	G	L	V	V	V	F	T	A
Secondary structure
SS confidence
Disorder																																			?			?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	V	L	L	L	S	Y	W	P	A	R	N	L	L	S	S	H	Q	R	M	N	M	S	F	N	P	F	H	L	V	N	T	Y	G	A	F	G	S	I	C	R	T	R	R	E	V	V	I	E	G	T	D	E	S	P	I	T	E	Q	T
Secondary structure
SS confidence
Disorder											?	?	?			?							?												?																			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	W	K	A	Y	E	F	K	G	K	P	G	D	P	R	R	L	P	R	Q	W	A	P	Y	H	L	R	L	D	W	L	M	W	F	A	A	I	S	P	G	Y	A	L	P	W	M	T	P	F	L	N	R	L	L	R	N	D	P	A	T
Secondary structure
SS confidence
Disorder																																						?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	K	L	L	R	H	N	P	F	P	Q	S	P	P	R	Y	V	R	A	Q	L	Y	Q	Y	R	F	T	T	V	A	E	L	R	R	D	R	A	W	W	H	R	T	L	I	G	R	Y	V	P	P	M	S	L	R	K	V	A	S	P	P
Secondary structure
SS confidence
Disorder								?	?																					?			?	?	?	?	?	?	?															?	?	?	?	?	?	?	?
Disorder confidence
		.	.
Sequence		A	D
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 57%) Beta strand ( 10%) TM helix ( 38%) (View membrane topology prediction)

Rank Aligned region

PDB 2dmo chain A Region: 430 - 480 Aligned: 50 Modelled: 51 Confidence: 35.4% Identity: 28% PDB header:signaling protein Chain: A: PDB Molecule:neutrophil cytosol factor 2; PDBTitle: refined solution structure of the 1st sh3 domain from human2 neutrophil cytosol factor 2 (ncf-2) Phyre2 PDB 4rdb chain A Region: 346 - 403 Aligned: 46 Modelled: 58 Confidence: 28.2% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:immunoreactive 32 kda antigen pg49; PDBTitle: crystal structure of an immunoreactive 32 kda antigen pg49 (pg_0181)2 from porphyromonas gingivalis w83 at 1.45 a resolution (psi community3 target, nakayama) Phyre2 PDB 1tvx chain A Region: 400 - 417 Aligned: 18 Modelled: 18 Confidence: 25.9% Identity: 17% Fold: IL8-like Superfamily: Interleukin 8-like chemokines Family: Interleukin 8-like chemokines Phyre2 PDB 2eqi chain A Region: 430 - 480 Aligned: 50 Modelled: 51 Confidence: 24.0% Identity: 30% PDB header:immune system, hydrolase Chain: A: PDB Molecule:phospholipase c, gamma 2; PDBTitle: solution structure of the sh3 domain from phospholipase c,2 gamma 2 Phyre2 PDB 3hx6 chain A Region: 321 - 354 Aligned: 34 Modelled: 34 Confidence: 21.6% Identity: 21% PDB header:cell adhesion Chain: A: PDB Molecule:type 4 fimbrial biogenesis protein pily1; PDBTitle: crystal structure of pseudomonas aeruginosa pily1 c-terminal2 domain Phyre2 PDB 1ue9 chain A Region: 431 - 480 Aligned: 49 Modelled: 50 Confidence: 21.5% Identity: 27% Fold: SH3-like barrel Superfamily: SH3-domain Family: SH3-domain Phyre2 PDB 2dbk chain A Region: 428 - 482 Aligned: 54 Modelled: 55 Confidence: 20.6% Identity: 20% PDB header:signaling protein Chain: A: PDB Molecule:crk-like protein; PDBTitle: solution structures of the sh3 domain of human crk-like2 protein Phyre2 PDB 1tvx chain B Region: 400 - 417 Aligned: 18 Modelled: 18 Confidence: 20.0% Identity: 17% Fold: IL8-like Superfamily: Interleukin 8-like chemokines Family: Interleukin 8-like chemokines Phyre2 PDB 3wmm chain Y Region: 223 - 258 Aligned: 35 Modelled: 35 Confidence: 18.8% Identity: 23% PDB header:photosynthesis Chain: Y: PDB Molecule:lh1 alpha polypeptide; PDBTitle: crystal structure of the lh1-rc complex from thermochromatium tepidum2 in c2 form Phyre2 PDB 6et5 chain B Region: 223 - 258 Aligned: 36 Modelled: 36 Confidence: 18.8% Identity: 17% PDB header:photosynthesis Chain: B: PDB Molecule: PDBTitle: reaction centre light harvesting complex 1 from blc. virids Phyre2 PDB 2d8h chain A Region: 430 - 480 Aligned: 50 Modelled: 51 Confidence: 16.9% Identity: 24% PDB header:unknown function Chain: A: PDB Molecule:sh3yl1 protein; PDBTitle: solution structure of the sh3 domain of hypothetical2 protein sh3yl1 Phyre2 PDB 3h35 chain B Region: 411 - 460 Aligned: 42 Modelled: 50 Confidence: 16.8% Identity: 21% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein abo_0056; PDBTitle: structure of the uncharacterized protein abo_0056 from the2 hydrocarbon-degrading marine bacterium alcanivorax borkumensis sk2. Phyre2 PDB 2eyx chain A Region: 430 - 478 Aligned: 48 Modelled: 49 Confidence: 16.8% Identity: 25% PDB header:signaling protein Chain: A: PDB Molecule:v-crk sarcoma virus ct10 oncogene homolog PDBTitle: c-terminal sh3 domain of ct10-regulated kinase Phyre2 PDB 1xrd chain A Region: 223 - 258 Aligned: 36 Modelled: 36 Confidence: 16.8% Identity: 28% PDB header:membrane protein Chain: A: PDB Molecule:light-harvesting protein b-880, alpha chain; PDBTitle: light-harvesting complex 1 alfa subunit from wild-type2 rhodospirillum rubrum Phyre2 PDB 1xrd chain A domain 1 Region: 223 - 258 Aligned: 36 Modelled: 36 Confidence: 16.8% Identity: 28% Fold: Light-harvesting complex subunits Superfamily: Light-harvesting complex subunits Family: Light-harvesting complex subunits Phyre2 PDB 1w7c chain A domain 2 Region: 416 - 442 Aligned: 25 Modelled: 27 Confidence: 16.5% Identity: 32% Fold: Cystatin-like Superfamily: Amine oxidase N-terminal region Family: Amine oxidase N-terminal region Phyre2 PDB 4z8a chain A Region: 427 - 475 Aligned: 48 Modelled: 49 Confidence: 15.9% Identity: 27% PDB header:rim-binding protein Chain: A: PDB Molecule:rim-binding protein, isoform f; PDBTitle: sh3-iii of drosophila rim-binding protein bound to a cacophony derived2 peptide Phyre2 PDB 2k2m chain A Region: 428 - 465 Aligned: 37 Modelled: 38 Confidence: 15.6% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:eps8-like protein 1; PDBTitle: structural basis of pxxdy motif recognition in sh3 binding Phyre2 PDB 4d1i chain B Region: 412 - 444 Aligned: 28 Modelled: 33 Confidence: 14.4% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:beta-galactosidase, putative, bgl35a; PDBTitle: the structure of the gh35 beta-galactosidase bgl35a from2 cellvibrio japonicus Phyre2 PDB 4zad chain B Region: 345 - 380 Aligned: 36 Modelled: 36 Confidence: 14.2% Identity: 19% PDB header:lyase Chain: B: PDB Molecule:fdc1; PDBTitle: structure of c. dubliensis fdc1 with the prenylated-flavin cofactor in2 the iminium form. Phyre2 1 c2dmoA_ 2 c4rdbA_ 3 d1tvxa_ 4 c2eqiA_ 5 c3hx6A_ 6 d1ue9a_ 7 c2dbkA_ 8 d1tvxb_ 9 c3wmmY_ 10 c6et5b_ 11 c2d8hA_ 12 c3h35B_ 13 c2eyxA_ 14 c1xrdA_ 15 d1xrda1 16 d1w7ca2 17 c4z8aA_ 18 c2k2mA_ 19 c4d1iB_ 20 c4zadB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83