1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	N	L	A	L	W	S	R	P	V	W	D	V	E	P	W	D	R	W	L	R	D	F	F	G	P	A	A	T	T	D	W	Y	R	P	V	A	G	D	F	T	P	A	A	E	I	V	K	D	G	D	D	A	V	V	R	L	E	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	I	D	V	D	K	D	V	N	V	E	L	D	P	G	Q	P	V	S	R	L	V	I	R	G	E	H	R	D	E	H	T	Q	D	A	G	D	K	D	G	R	T	L	R	E	I	R	Y	G	S	F	R	R	S	F	R	L	P	A
Secondary structure
SS confidence
Disorder																				?										?	?	?	?	?	?	?	?	?	?	?	?											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.
Sequence		H	V	T	S	E	A	I	A	A	S	Y	D	A	G	V	L	T	V	R	V	A	G	A	Y	K	A	P	A	E	T	Q	A	Q	R	I	A	I	T	K
Secondary structure
SS confidence
Disorder																							?	?	?	?	?	?	?	?	?	?	?					?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 33%) Alpha helix ( 13%) Beta strand ( 43%)

Rank Aligned region

PDB 1gme chain A Region: 1 - 158 Aligned: 147 Modelled: 158 Confidence: 99.9% Identity: 23% Fold: HSP20-like chaperones Superfamily: HSP20-like chaperones Family: HSP20 Phyre2 PDB 3w1z chain A Region: 20 - 158 Aligned: 130 Modelled: 139 Confidence: 99.9% Identity: 28% PDB header:chaperone Chain: A: PDB Molecule:heat shock protein 16; PDBTitle: heat shock protein 16.0 from schizosaccharomyces pombe Phyre2 PDB 2ygd chain V Region: 5 - 159 Aligned: 137 Modelled: 151 Confidence: 99.9% Identity: 26% PDB header:chaperone Chain: V: PDB Molecule: PDBTitle: molecular architectures of the 24meric eye lens chaperone alphab-2 crystallin elucidated by a triple hybrid approach Phyre2 PDB 5mb8 chain J Region: 1 - 158 Aligned: 142 Modelled: 158 Confidence: 99.9% Identity: 19% PDB header:chaperone Chain: J: PDB Molecule:25.3 kda heat shock protein, chloroplastic; PDBTitle: hsp21 dodecamer, structural model based on cryo-em and homology2 modelling Phyre2 PDB 6dv5 chain T Region: 4 - 158 Aligned: 136 Modelled: 151 Confidence: 99.9% Identity: 22% PDB header:chaperone Chain: T: PDB Molecule:heat shock protein beta-1; PDBTitle: oligomeric complex of a hsp27 24-mer at 3.6 a resolution Phyre2 PDB 3w1z chain D Region: 40 - 158 Aligned: 110 Modelled: 119 Confidence: 99.9% Identity: 31% PDB header:chaperone Chain: D: PDB Molecule:heat shock protein 16; PDBTitle: heat shock protein 16.0 from schizosaccharomyces pombe Phyre2 PDB 1gme chain B Region: 42 - 158 Aligned: 108 Modelled: 117 Confidence: 99.9% Identity: 30% Fold: HSP20-like chaperones Superfamily: HSP20-like chaperones Family: HSP20 Phyre2 PDB 1shs chain A Region: 38 - 158 Aligned: 110 Modelled: 117 Confidence: 99.9% Identity: 23% Fold: HSP20-like chaperones Superfamily: HSP20-like chaperones Family: HSP20 Phyre2 PDB 1shs chain D Region: 38 - 158 Aligned: 110 Modelled: 117 Confidence: 99.9% Identity: 23% PDB header:heat shock protein Chain: D: PDB Molecule:small heat shock protein; PDBTitle: small heat shock protein from methanococcus jannaschii Phyre2 PDB 3gla chain A Region: 39 - 143 Aligned: 97 Modelled: 102 Confidence: 99.9% Identity: 33% PDB header:chaperone Chain: A: PDB Molecule:low molecular weight heat shock protein; PDBTitle: crystal structure of the hspa from xanthomonas axonopodis Phyre2 PDB 3l1e chain A Region: 42 - 159 Aligned: 103 Modelled: 118 Confidence: 99.9% Identity: 24% PDB header:chaperone Chain: A: PDB Molecule:alpha-crystallin a chain; PDBTitle: bovine alphaa crystallin zinc bound Phyre2 PDB 4fei chain A Region: 38 - 148 Aligned: 98 Modelled: 111 Confidence: 99.9% Identity: 31% PDB header:chaperone Chain: A: PDB Molecule:heat shock protein-related protein; PDBTitle: hsp17.7 from deinococcus radiodurans Phyre2 PDB 4ydz chain A Region: 21 - 159 Aligned: 120 Modelled: 139 Confidence: 99.9% Identity: 23% PDB header:chaperone Chain: A: PDB Molecule:stress-induced protein 1; PDBTitle: stress-induced protein 1 from caenorhabditis elegans Phyre2 PDB 5mb8 chain L Region: 42 - 158 Aligned: 102 Modelled: 110 Confidence: 99.8% Identity: 25% PDB header:chaperone Chain: L: PDB Molecule:25.3 kda heat shock protein, chloroplastic; PDBTitle: hsp21 dodecamer, structural model based on cryo-em and homology2 modelling Phyre2 PDB 2bol chain A Region: 1 - 151 Aligned: 135 Modelled: 151 Confidence: 99.8% Identity: 17% PDB header:heat shock protein Chain: A: PDB Molecule:small heat shock protein; PDBTitle: crystal structure and assembly of tsp36, a metazoan small heat shock2 protein Phyre2 PDB 6ewn chain A Region: 40 - 145 Aligned: 98 Modelled: 106 Confidence: 99.8% Identity: 32% PDB header:chaperone Chain: A: PDB Molecule:hspa; PDBTitle: hspa from thermosynechococcus vulcanus in the presence of 2m urea with2 initial stages of denaturation Phyre2 PDB 2h50 chain A domain 1 Region: 44 - 142 Aligned: 92 Modelled: 99 Confidence: 99.8% Identity: 32% Fold: HSP20-like chaperones Superfamily: HSP20-like chaperones Family: HSP20 Phyre2 PDB 5ds1 chain B Region: 42 - 140 Aligned: 89 Modelled: 99 Confidence: 99.8% Identity: 30% PDB header:chaperone Chain: B: PDB Molecule:17.1 kda class ii heat shock protein; PDBTitle: core domain of the class ii small heat-shock protein hsp 17.7 from2 pisum sativum Phyre2 PDB 4zjd chain F Region: 42 - 142 Aligned: 91 Modelled: 101 Confidence: 99.8% Identity: 31% PDB header:chaperone Chain: F: PDB Molecule:aggregation suppressing protein; PDBTitle: small heat shock protein agsa from salmonella typhimurium: truncations2 at n- and c- termini Phyre2 PDB 3aab chain A Region: 32 - 151 Aligned: 109 Modelled: 120 Confidence: 99.8% Identity: 25% PDB header:chaperone Chain: A: PDB Molecule:putative uncharacterized protein st1653; PDBTitle: small heat shock protein hsp14.0 with the mutations of i120f and i122f2 in the form i crystal Phyre2 1 d1gmea_ 2 c3w1zA_ 3 c2ygdV_ 4 c5mb8J_ 5 c6dv5T_ 6 c3w1zD_ 7 d1gmeb_ 8 d1shsa_ 9 c1shsD_ 10 c3glaA_ 11 c3l1eA_ 12 c4feiA_ 13 c4ydzA_ 14 c5mb8L_ 15 c2bolA_ 16 c6ewnA_ 17 d2h50a1 18 c5ds1B_ 19 c4zjdF_ 20 c3aabA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99