1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	R	S	Q	E	P	S	R	G	L	L	D	P	V	A	K	M	L	R	L	P	F	G	T	P	D	F	I	E	K	I	V	T	G	S	V	N	Q	V	G	R	R	T	L	Y	V	L	I	T	T	W	D	A	A	G	G	G	P	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	S	A	I	A	T	T	G	L	A	K	T	A	E	I	V	Q	S	M	F	I	G	P	V	F	N	P	L	L	K	M	L	G	A	D	K	I	A	I	R	A	S	L	C	A	A	Q	L	V	G	L	G	I	M	R	Y	G	V	R
Secondary structure
SS confidence
Disorder									?	?																									?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Sequence		S	E	P	L	H	S	M	S	V	E	M	L	V	D	A	I	G	P	T	M	Q	R	Y	L	V	G	D	I	G	R	G
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 13%) Alpha helix ( 73%) Beta strand ( 0%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 2np3 chain A Region: 13 - 146 Aligned: 128 Modelled: 134 Confidence: 100.0% Identity: 23% PDB header:transcription Chain: A: PDB Molecule:putative tetr-family regulator; PDBTitle: crystal structure of tetr-family regulator (sco0857) from streptomyces2 coelicolor a3. Phyre2 PDB 2np3 chain A domain 2 Region: 38 - 146 Aligned: 103 Modelled: 109 Confidence: 100.0% Identity: 24% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 2guh chain A Region: 10 - 146 Aligned: 135 Modelled: 137 Confidence: 99.0% Identity: 15% PDB header:transcription Chain: A: PDB Molecule:putative tetr-family transcriptional regulator; PDBTitle: crystal structure of the putative tetr-family transcriptional2 regulator from rhodococcus sp. rha1 Phyre2 PDB 2fq4 chain A domain 2 Region: 35 - 136 Aligned: 102 Modelled: 102 Confidence: 96.8% Identity: 20% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 2id3 chain A domain 2 Region: 34 - 136 Aligned: 103 Modelled: 103 Confidence: 95.4% Identity: 14% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 5d1w chain D Region: 13 - 143 Aligned: 130 Modelled: 131 Confidence: 93.6% Identity: 12% PDB header:transcription Chain: D: PDB Molecule:rv3249c transcriptional regulator; PDBTitle: crystal structure of mycobacterium tuberculosis rv3249c2 transcriptional regulator. Phyre2 PDB 5ydp chain C Region: 27 - 148 Aligned: 118 Modelled: 122 Confidence: 91.7% Identity: 14% PDB header:gene regulation Chain: C: PDB Molecule:tetr transcriptional regulatory protein; PDBTitle: crystal structure of tetr family repressor alkx from dietzia sp.2 strain dq12-45-1b implicated in biodegradation of n-alkanes Phyre2 PDB 2np5 chain A domain 2 Region: 35 - 147 Aligned: 109 Modelled: 113 Confidence: 91.2% Identity: 22% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 5x5i chain C Region: 34 - 139 Aligned: 101 Modelled: 106 Confidence: 90.0% Identity: 8% PDB header:transcription Chain: C: PDB Molecule:hth-type transcriptional regulator rcda; PDBTitle: the x-ray crystal structure of a tetr family transcription regulator2 rcda involved in the regulation of biofilm formation in escherichia3 coli Phyre2 PDB 1t56 chain A domain 2 Region: 34 - 147 Aligned: 109 Modelled: 114 Confidence: 87.6% Identity: 10% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 3g56 chain A Region: 25 - 140 Aligned: 116 Modelled: 116 Confidence: 82.3% Identity: 7% PDB header:dna binding protein Chain: A: PDB Molecule:regulator of macrolide 2'-phosphotransferase i; PDBTitle: structure of the macrolide biosensor protein, mphr(a) Phyre2 PDB 2zb9 chain A Region: 34 - 136 Aligned: 103 Modelled: 103 Confidence: 68.3% Identity: 20% PDB header:transcription Chain: A: PDB Molecule:putative transcriptional regulator; PDBTitle: crystal structure of tetr family transcription regulator2 sco0332 Phyre2 PDB 6g8h chain C Region: 9 - 150 Aligned: 130 Modelled: 142 Confidence: 67.5% Identity: 12% PDB header:transcription Chain: C: PDB Molecule:tetr/acrr family transcriptional regulator; PDBTitle: flavonoid-responsive regulator frra in complex with naringenin Phyre2 PDB 2id3 chain A Region: 34 - 144 Aligned: 111 Modelled: 111 Confidence: 55.5% Identity: 13% PDB header:transcription Chain: A: PDB Molecule:putative transcriptional regulator; PDBTitle: crystal structure of transcriptional regulator sco5951 from2 streptomyces coelicolor a3(2) Phyre2 PDB 2gen chain A domain 2 Region: 42 - 137 Aligned: 95 Modelled: 96 Confidence: 52.0% Identity: 8% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 1t33 chain A domain 2 Region: 42 - 146 Aligned: 105 Modelled: 105 Confidence: 51.7% Identity: 9% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 2qib chain A Region: 34 - 144 Aligned: 110 Modelled: 110 Confidence: 50.1% Identity: 12% PDB header:transcription Chain: A: PDB Molecule:tetr-family transcriptional regulator; PDBTitle: crystal structure of tetr-family transcriptional regulator from2 streptomyces coelicolor Phyre2 PDB 5mru chain A Region: 34 - 146 Aligned: 104 Modelled: 113 Confidence: 42.1% Identity: 11% PDB header:transcription Chain: A: PDB Molecule:tetracycline repressor, class a; PDBTitle: tetr(class a) in complex with 5a,6-anhydrotetracycline and magnesium Phyre2 PDB 1t33 chain B Region: 36 - 146 Aligned: 111 Modelled: 111 Confidence: 40.4% Identity: 7% PDB header:transcription Chain: B: PDB Molecule:putative transcriptional repressor (tetr/acrr family); PDBTitle: structural genomics, the crystal structure of a putative2 transcriptional repressor (tetr/acrr family) from salmonella3 typhimurim lt2 Phyre2 PDB 2fq4 chain A Region: 34 - 136 Aligned: 103 Modelled: 103 Confidence: 35.9% Identity: 20% PDB header:transcription regulator Chain: A: PDB Molecule:transcriptional regulator, tetr family; PDBTitle: the crystal structure of the transcriptional regulator (tetr family)2 from bacillus cereus Phyre2 1 c2np3A_ 2 d2np3a2 3 c2guhA_ 4 d2fq4a2 5 d2id3a2 6 c5d1wD_ 7 c5ydpC_ 8 d2np5a2 9 c5x5iC_ 10 d1t56a2 11 c3g56A_ 12 c2zb9A_ 13 c6g8hC_ 14 c2id3A_ 15 d2gena2 16 d1t33a2 17 c2qibA_ 18 c5mruA_ 19 c1t33B_ 20 c2fq4A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70