1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	L	I	L	T	A	H	G	T	R	R	P	S	G	V	A	M	I	A	D	I	A	A	Q	V	S	A	L	V	D	R	T	V	Q	V	A	F	V	D	V	L	G	P	S	P	S	E	V	L	S	A	L	S	C	R	P	A	I	V
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	P	A	F	L	S	R	G	Y	H	V	R	T	D	L	P	A	H	V	A	A	S	A	H	P	H	V	T	V	T	P	A	L	G	P	C	R	E	I	A	Q	I	V	T	Q	Q	L	V	E	S	G	W	R	P	G	D	S	V	I	L
Secondary structure
SS confidence
Disorder																								?																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	A	G	A	S	D	R	R	A	R	A	D	L	H	T	T	R	T	L	V	S	E	L	T	G	S	W	V	D	M	G	F	A	G	T	G	G	P	D	V	R	T	A	V	Q	R	A	R	D	R	A	E	A	N	R	G	A	R	R
Secondary structure
SS confidence
Disorder									?																																												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	A	V	A	S	F	L	L	A	E	G	L	F	Q	E	R	L	R	A	S	G	A	D	V	V	T	R	P	L	G	T	H	P	G	L	A	Q	L	V	A	N	R	F	R	S	A	V	A	R	Q	Q	R	L	H	R	W	H	G	T	P
Secondary structure
SS confidence
Disorder																																																	?			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.
Sequence		T	P	V	T	L	D	L
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 48%) Beta strand ( 18%)

Rank Aligned region

PDB 5zt7 chain A Region: 2 - 238 Aligned: 232 Modelled: 237 Confidence: 100.0% Identity: 19% PDB header:biosynthetic protein Chain: A: PDB Molecule:sirohydrochlorin ferrochelatase; PDBTitle: sirb from bacillus subtilis with co2+ Phyre2 PDB 2jh3 chain C Region: 2 - 233 Aligned: 222 Modelled: 226 Confidence: 100.0% Identity: 24% PDB header:ribosomal protein Chain: C: PDB Molecule:ribosomal protein s2-related protein; PDBTitle: the crystal structure of dr2241 from deinococcus2 radiodurans at 1.9 a resolution reveals a multi-domain3 protein with structural similarity to chelatases but also4 with two additional novel domains Phyre2 PDB 2xvz chain A Region: 2 - 231 Aligned: 222 Modelled: 228 Confidence: 100.0% Identity: 21% PDB header:metal binding protein Chain: A: PDB Molecule:chelatase, putative; PDBTitle: cobalt chelatase cbik (periplasmatic) from desulvobrio2 vulgaris hildenborough (co-crystallized with cobalt) Phyre2 PDB 1qgo chain A Region: 2 - 227 Aligned: 217 Modelled: 226 Confidence: 100.0% Identity: 18% Fold: Chelatase-like Superfamily: Chelatase Family: Cobalt chelatase CbiK Phyre2 PDB 4ccs chain A Region: 2 - 228 Aligned: 211 Modelled: 227 Confidence: 100.0% Identity: 21% PDB header:unknown function Chain: A: PDB Molecule:cbix; PDBTitle: the structure of cbix, the terminal enzyme for biosynthesis2 of siroheme in denitrifying bacteria Phyre2 PDB 1tjn chain A Region: 2 - 111 Aligned: 110 Modelled: 110 Confidence: 99.9% Identity: 22% PDB header:lyase Chain: A: PDB Molecule:sirohydrochlorin cobaltochelatase; PDBTitle: crystal structure of hypothetical protein af0721 from archaeoglobus2 fulgidus Phyre2 PDB 1tjn chain A Region: 2 - 111 Aligned: 110 Modelled: 110 Confidence: 99.9% Identity: 22% Fold: Chelatase-like Superfamily: Chelatase Family: CbiX-like Phyre2 PDB 2hk6 chain A domain 1 Region: 1 - 229 Aligned: 224 Modelled: 229 Confidence: 99.9% Identity: 16% Fold: Chelatase-like Superfamily: Chelatase Family: Ferrochelatase Phyre2 PDB 3lyh chain B Region: 2 - 116 Aligned: 113 Modelled: 115 Confidence: 99.9% Identity: 21% PDB header:lyase Chain: B: PDB Molecule:cobalamin (vitamin b12) biosynthesis cbix protein; PDBTitle: crystal structure of putative cobalamin (vitamin b12) biosynthesis2 cbix protein (yp_958415.1) from marinobacter aquaeolei vt8 at 1.60 a3 resolution Phyre2 PDB 2hrc chain A domain 1 Region: 2 - 229 Aligned: 221 Modelled: 228 Confidence: 99.8% Identity: 14% Fold: Chelatase-like Superfamily: Chelatase Family: Ferrochelatase Phyre2 PDB 1lbq chain A Region: 9 - 228 Aligned: 212 Modelled: 220 Confidence: 99.5% Identity: 12% Fold: Chelatase-like Superfamily: Chelatase Family: Ferrochelatase Phyre2 PDB 3ct6 chain A domain 1 Region: 1 - 61 Aligned: 58 Modelled: 61 Confidence: 54.1% Identity: 9% Fold: PTS system fructose IIA component-like Superfamily: PTS system fructose IIA component-like Family: DhaM-like Phyre2 PDB 2dji chain A domain 1 Region: 91 - 157 Aligned: 57 Modelled: 67 Confidence: 44.0% Identity: 14% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 3b48 chain A domain 1 Region: 1 - 61 Aligned: 58 Modelled: 61 Confidence: 42.2% Identity: 14% Fold: PTS system fructose IIA component-like Superfamily: PTS system fructose IIA component-like Family: DhaM-like Phyre2 PDB 2eh6 chain A Region: 92 - 211 Aligned: 108 Modelled: 120 Confidence: 35.0% Identity: 14% PDB header:transferase Chain: A: PDB Molecule:acetylornithine aminotransferase; PDBTitle: crystal structure of acetylornithine aminotransferase from aquifex2 aeolicus vf5 Phyre2 PDB 1ybh chain A domain 1 Region: 92 - 157 Aligned: 56 Modelled: 66 Confidence: 34.0% Identity: 21% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 2uwj chain E Region: 210 - 240 Aligned: 31 Modelled: 31 Confidence: 30.1% Identity: 19% PDB header:chaperone Chain: E: PDB Molecule:type iii export protein psce; PDBTitle: structure of the heterotrimeric complex which regulates type iii2 secretion needle formation Phyre2 PDB 2ji7 chain A domain 1 Region: 95 - 141 Aligned: 43 Modelled: 47 Confidence: 29.4% Identity: 12% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1pvd chain A domain 1 Region: 95 - 141 Aligned: 47 Modelled: 47 Confidence: 29.3% Identity: 21% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 PDB 1q6z chain A domain 1 Region: 95 - 141 Aligned: 43 Modelled: 47 Confidence: 27.0% Identity: 14% Fold: DHS-like NAD/FAD-binding domain Superfamily: DHS-like NAD/FAD-binding domain Family: Pyruvate oxidase and decarboxylase, middle domain Phyre2 1 c5zt7A_ 2 c2jh3C_ 3 c2xvzA_ 4 d1qgoa_ 5 c4ccsA_ 6 c1tjnA_ 7 d1tjna_ 8 d2hk6a1 9 c3lyhB_ 10 d2hrca1 11 d1lbqa_ 12 d3ct6a1 13 d2djia1 14 d3b48a1 15 c2eh6A_ 16 d1ybha1 17 c2uwjE_ 18 d2ji7a1 19 d1pvda1 20 d1q6za1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99