1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	A	A	L	A	C	T	V	L	D	Y	G	D	H	A	L	M	L	Q	C	D	S	T	A	D	A	M	A	W	T	D	A	L	R	A	A	A	L	P	G	V	V	D	I	V	A	A	S	R	T	V	L	V	K	L	D	A	P	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	Q	G	V	T	R	Q	R	L	R	R	L	R	V	T	P	E	A	V	A	A	A	D	H	R	C	D	L	V	I	D	V	V	Y	D	G	P	D	L	A	E	V	A	R	C	T	G	L	T	T	A	A	V	I	N	A	H	T	A	T
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	W	R	A	G	F	S	G	S	A	P	G	F	A	Y	L	I	D	G	D	P	S	L	R	V	P	R	R	P	E	R	R	T	S	M	P	P	G	S	V	A	L	A	D	G	F	S	A	I	Y	P	S	Q	A	P	S	D	W	Q	I
Secondary structure
SS confidence
Disorder																											?					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence		I	G	H	T	D	A	V	L	W	D	V	D	R	P	Q	P	A	L	L	T	P	G	M	W	V	Q	F	R	A	A
Secondary structure
SS confidence
Disorder																															?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 23%) Beta strand ( 29%) TM helix ( 8%) (View membrane topology prediction)

Rank Aligned region

PDB 3mml chain D Region: 7 - 209 Aligned: 203 Modelled: 203 Confidence: 100.0% Identity: 64% PDB header:hydrolase Chain: D: PDB Molecule:allophanate hydrolase subunit 1; PDBTitle: allophanate hydrolase complex from mycobacterium smegmatis, msmeg0435-2 msmeg0436 Phyre2 PDB 2phc chain B Region: 9 - 209 Aligned: 199 Modelled: 201 Confidence: 100.0% Identity: 27% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein ph0987; PDBTitle: crystal structure of conserved uncharacterized protein ph0987 from2 pyrococcus horikoshii Phyre2 PDB 3oep chain A Region: 15 - 210 Aligned: 185 Modelled: 196 Confidence: 100.0% Identity: 35% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha0988; PDBTitle: crystal structure of ttha0988 in space group p43212 Phyre2 PDB 5dud chain B Region: 6 - 209 Aligned: 189 Modelled: 204 Confidence: 100.0% Identity: 32% PDB header:unknown function Chain: B: PDB Molecule:ybgj; PDBTitle: crystal structure of e. coli ybgjk Phyre2 PDB 2phc chain B domain 1 Region: 88 - 209 Aligned: 122 Modelled: 122 Confidence: 100.0% Identity: 34% Fold: Cyclophilin-like Superfamily: Cyclophilin-like Family: PH0987 C-terminal domain-like Phyre2 PDB 2zp2 chain B Region: 86 - 209 Aligned: 115 Modelled: 124 Confidence: 100.0% Identity: 37% PDB header:transferase inhibitor Chain: B: PDB Molecule:kinase a inhibitor; PDBTitle: c-terminal domain of kipi from bacillus subtilis Phyre2 PDB 5i8i chain D Region: 2 - 208 Aligned: 206 Modelled: 207 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: D: PDB Molecule:urea amidolyase; PDBTitle: crystal structure of the k. lactis urea amidolyase Phyre2 PDB 3va7 chain A Region: 8 - 209 Aligned: 201 Modelled: 202 Confidence: 100.0% Identity: 18% PDB header:ligase Chain: A: PDB Molecule:klla0e08119p; PDBTitle: crystal structure of the kluyveromyces lactis urea carboxylase Phyre2 PDB 2kwa chain A Region: 4 - 85 Aligned: 82 Modelled: 82 Confidence: 99.5% Identity: 18% PDB header:transferase inhibitor Chain: A: PDB Molecule:kinase a inhibitor; PDBTitle: 1h, 13c and 15n backbone and side chain resonance assignments of the2 n-terminal domain of the histidine kinase inhibitor kipi from3 bacillus subtilis Phyre2 PDB 2phc chain B domain 2 Region: 9 - 85 Aligned: 77 Modelled: 77 Confidence: 99.4% Identity: 14% Fold: DCoH-like Superfamily: PH0987 N-terminal domain-like Family: PH0987 N-terminal domain-like Phyre2 PDB 2qf7 chain A Region: 98 - 189 Aligned: 89 Modelled: 92 Confidence: 97.0% Identity: 15% PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase protein; PDBTitle: crystal structure of a complete multifunctional pyruvate carboxylase2 from rhizobium etli Phyre2 PDB 3bg5 chain B Region: 98 - 203 Aligned: 95 Modelled: 99 Confidence: 95.8% Identity: 13% PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of staphylococcus aureus pyruvate carboxylase Phyre2 PDB 5vz0 chain D Region: 98 - 184 Aligned: 86 Modelled: 87 Confidence: 95.5% Identity: 16% PDB header:ligase Chain: D: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of lactococcus lactis pyruvate carboxylase g746a2 mutant in complex with cyclic-di-amp Phyre2 PDB 3hbl chain A Region: 98 - 203 Aligned: 95 Modelled: 106 Confidence: 95.3% Identity: 13% PDB header:ligase Chain: A: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of s. aureus pyruvate carboxylase t908a mutant Phyre2 PDB 4hnv chain B Region: 98 - 196 Aligned: 95 Modelled: 99 Confidence: 90.1% Identity: 11% PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of r54e mutant of s. aureus pyruvate carboxylase Phyre2 PDB 3tw6 chain B Region: 98 - 190 Aligned: 92 Modelled: 93 Confidence: 89.6% Identity: 10% PDB header:ligase/activator Chain: B: PDB Molecule:pyruvate carboxylase protein; PDBTitle: structure of rhizobium etli pyruvate carboxylase t882a with the2 allosteric activator, acetyl coenzyme-a Phyre2 PDB 4qsk chain B Region: 98 - 189 Aligned: 85 Modelled: 92 Confidence: 74.9% Identity: 14% PDB header:ligase Chain: B: PDB Molecule:pyruvate carboxylase; PDBTitle: crystal structure of l. monocytogenes pyruvate carboxylase in complex2 with cyclic-di-amp Phyre2 PDB 1nza chain A Region: 17 - 107 Aligned: 87 Modelled: 91 Confidence: 73.5% Identity: 14% Fold: Ferredoxin-like Superfamily: GlnB-like Family: Divalent ion tolerance proteins CutA (CutA1) Phyre2 PDB 3mml chain E Region: 136 - 208 Aligned: 68 Modelled: 73 Confidence: 70.3% Identity: 24% PDB header:hydrolase Chain: E: PDB Molecule:allophanate hydrolase subunit 2; PDBTitle: allophanate hydrolase complex from mycobacterium smegmatis, msmeg0435-2 msmeg0436 Phyre2 PDB 1nwa chain A Region: 30 - 106 Aligned: 77 Modelled: 77 Confidence: 62.6% Identity: 18% Fold: Ferredoxin-like Superfamily: Peptide methionine sulfoxide reductase Family: Peptide methionine sulfoxide reductase Phyre2 1 c3mmlD_ 2 c2phcB_ 3 c3oepA_ 4 c5dudB_ 5 d2phcb1 6 c2zp2B_ 7 c5i8iD_ 8 c3va7A_ 9 c2kwaA_ 10 d2phcb2 11 c2qf7A_ 12 c3bg5B_ 13 c5vz0D_ 14 c3hblA_ 15 c4hnvB_ 16 c3tw6B_ 17 c4qskB_ 18 d1nzaa_ 19 c3mmlE_ 20 d1nwaa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99