1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	R	M	A	A	P	V	S	L	D	V	H	G	R	Q	V	I	V	T	H	P	G	R	V	V	F	P	A	H	N	D	R	K	G	Y	T	K	F	D	L	V	R	Y	Y	L	A	V	A	E	G	A	M	R	G	V	A	G	R	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	I	L	K	R	F	V	K	G	I	S	A	E	A	V	F	Q	K	R	A	P	A	N	R	P	D	W	V	D	V	A	E	L	H	Y	A	S	G	R	S	A	A	E	A	V	I	H	D	A	A	G	L	A	W	V	I	N	L	G	C
Secondary structure
SS confidence
Disorder																																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	D	L	N	P	H	P	V	L	A	G	D	L	D	H	P	D	E	L	R	V	D	L	D	P	M	P	G	V	A	W	Q	R	V	V	E	V	A	L	V	V	R	E	V	L	E	D	Y	G	L	T	A	W	P	K	T	S	G	S	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	F	H	V	Y	A	R	I	A	P	C	W	S	F	P	Q	V	R	L	A	A	Q	T	V	A	R	E	V	E	R	R	L	P	D	A	A	T	S	R	W	W	K	E	E	R	E	G	V	F	V	D	F	N	Q	N	A	K	D	R	T
Secondary structure
SS confidence
Disorder																																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	A	S	A	Y	S	V	R	A	T	P	D	A	R	V	S	T	P	L	H	W	E	E	V	P	G	C	D	P	A	V	F	T	M	A	T	V	P	S	R	L	A	D	I	G	D	P	W	A	G	M	D	D	A	V	G	R	L	D	R
Secondary structure
SS confidence
Disorder																														?																								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	L	M	L	A	E	E	L	G	P	P	Q	K	A	Q	S	A	K	P	L	I	E	I	A	R	A	K	T	R	A	E	A	M	A	A	L	D	I	W	R	D	R	Y	P	G	A	A	A	L	L	R	P	A	D	V	L	V	D	G	M
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?															?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.
Sequence		R	G	P	S	S	I	W	Y	R	I	R	I	N	L	Q	H	V	P	A	D	Q	R	P	P	Q	E	E	L	I	A	D	Y	S	P	W	P	R
Secondary structure
SS confidence
Disorder																			?	?	?	?	?	?	?	?						?		?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 15%) Alpha helix ( 34%) Beta strand ( 23%)

Rank Aligned region

PDB 5op0 chain B Region: 8 - 319 Aligned: 308 Modelled: 312 Confidence: 100.0% Identity: 48% PDB header:transferase Chain: B: PDB Molecule:dna polymerase ligd, polymerase domain; PDBTitle: structure of prim-polc from mycobacterium smegmatis Phyre2 PDB 5dmu chain A Region: 2 - 301 Aligned: 295 Modelled: 300 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:nhej polymerase; PDBTitle: structure of the nhej polymerase from methanocella paludicola Phyre2 PDB 2fao chain B Region: 9 - 303 Aligned: 288 Modelled: 295 Confidence: 100.0% Identity: 27% PDB header:hydrolase/transferase Chain: B: PDB Molecule:probable atp-dependent dna ligase; PDBTitle: crystal structure of pseudomonas aeruginosa ligd polymerase2 domain Phyre2 PDB 2iru chain A Region: 12 - 292 Aligned: 276 Modelled: 281 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:putative dna ligase-like protein rv0938/mt0965; PDBTitle: crystal structure of the polymerase domain from mycobacterium2 tuberculosis ligase d Phyre2 PDB 1zt2 chain A domain 1 Region: 30 - 204 Aligned: 146 Modelled: 146 Confidence: 97.8% Identity: 23% Fold: Prim-pol domain Superfamily: Prim-pol domain Family: PriA-like Phyre2 PDB 1v33 chain A Region: 36 - 186 Aligned: 101 Modelled: 98 Confidence: 97.1% Identity: 22% Fold: Prim-pol domain Superfamily: Prim-pol domain Family: PriA-like Phyre2 PDB 4bpx chain C Region: 89 - 186 Aligned: 98 Modelled: 98 Confidence: 96.8% Identity: 17% PDB header:transferase Chain: C: PDB Molecule:dna primase small subunit; PDBTitle: crystal structure of human primase in complex with the primase-2 binding motif of dna polymerase alpha Phyre2 PDB 4lim chain A Region: 139 - 204 Aligned: 66 Modelled: 66 Confidence: 96.6% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:dna primase small subunit; PDBTitle: crystal structure of the catalytic subunit of yeast primase Phyre2 PDB 1g71 chain A Region: 139 - 204 Aligned: 65 Modelled: 65 Confidence: 95.7% Identity: 20% Fold: Prim-pol domain Superfamily: Prim-pol domain Family: PriA-like Phyre2 PDB 1k1s chain A domain 2 Region: 44 - 182 Aligned: 137 Modelled: 139 Confidence: 82.7% Identity: 13% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1im4 chain A Region: 44 - 182 Aligned: 136 Modelled: 139 Confidence: 77.7% Identity: 13% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 1ro0 chain A Region: 137 - 186 Aligned: 43 Modelled: 50 Confidence: 76.1% Identity: 14% Fold: Prim-pol domain Superfamily: Prim-pol domain Family: Bifunctional DNA primase/polymerase N-terminal domain Phyre2 PDB 6a9w chain A Region: 137 - 186 Aligned: 45 Modelled: 50 Confidence: 71.9% Identity: 20% PDB header:replication Chain: A: PDB Molecule:primase; PDBTitle: structure of the bifunctional dna primase-polymerase from phage nrs-1 Phyre2 PDB 5gl6 chain A Region: 150 - 221 Aligned: 72 Modelled: 72 Confidence: 67.9% Identity: 6% PDB header:ribosomal protein Chain: A: PDB Molecule:ribosome maturation factor rimp; PDBTitle: msmeg rimp Phyre2 PDB 1jx4 chain A domain 2 Region: 40 - 180 Aligned: 139 Modelled: 141 Confidence: 63.8% Identity: 15% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: Lesion bypass DNA polymerase (Y-family), catalytic domain Phyre2 PDB 2xj9 chain B Region: 140 - 173 Aligned: 34 Modelled: 34 Confidence: 54.4% Identity: 24% PDB header:replication Chain: B: PDB Molecule:mipz; PDBTitle: dimer structure of the bacterial cell division regulator mipz Phyre2 PDB 5yrz chain D Region: 162 - 184 Aligned: 23 Modelled: 23 Confidence: 47.3% Identity: 30% PDB header:antitoxin/hydrolase Chain: D: PDB Molecule:hica; PDBTitle: toxin-antitoxin complex from streptococcus pneumoniae Phyre2 PDB 5yrz chain B Region: 162 - 184 Aligned: 23 Modelled: 23 Confidence: 47.0% Identity: 30% PDB header:antitoxin/hydrolase Chain: B: PDB Molecule:hica; PDBTitle: toxin-antitoxin complex from streptococcus pneumoniae Phyre2 PDB 2r7k chain A domain 2 Region: 166 - 206 Aligned: 35 Modelled: 41 Confidence: 46.0% Identity: 31% Fold: ATP-grasp Superfamily: Glutathione synthetase ATP-binding domain-like Family: PurP ATP-binding domain-like Phyre2 PDB 5kod chain A Region: 173 - 216 Aligned: 43 Modelled: 44 Confidence: 44.6% Identity: 12% PDB header:ligase Chain: A: PDB Molecule:indole-3-acetic acid-amido synthetase gh3.5; PDBTitle: crystal structure of gh3.5 acyl acid amido synthetase from arabidopsis2 thaliana Phyre2 1 c5op0B_ 2 c5dmuA_ 3 c2faoB_ 4 c2iruA_ 5 d1zt2a1 6 d1v33a_ 7 c4bpxC_ 8 c4limA_ 9 d1g71a_ 10 d1k1sa2 11 d1im4a_ 12 d1ro0a_ 13 c6a9wA_ 14 c5gl6A_ 15 d1jx4a2 16 c2xj9B_ 17 c5yrzD_ 18 c5yrzB_ 19 d2r7ka2 20 c5kodA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99