1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	I	S	L	V	A	H	Q	P	I	P	H	V	E	R	P	M	A	D	P	P	R	L	Q	L	A	R	R	R	R	S	A	A	G	P	G	G	N	E	D	S	L	M	G	V	A	L	L	A	G	P	A	N	V	I	M	E	L	A
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?		?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	P	G	V	G	Y	G	V	L	E	S	R	V	E	S	G	R	L	D	R	H	P	I	K	R	A	R	T	T	F	T	Y	V	A	V	A	V	A	G	S	D	D	Q	K	A	A	F	R	R	A	V	N	K	V	H	A	Q	V	Y	S
Secondary structure
SS confidence
Disorder																?	?	?																																									?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	P	E	S	P	V	S	Y	H	A	F	D	P	E	L	Q	L	W	V	A	A	C	L	Y	K	G	G	V	D	V	Y	R	T	F	V	G	E	M	D	D	E	E	A	D	H	H	Y	R	A	G	M	A	M	G	T	T	L	Q	V	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		P	Q	M	W	P	P	D	R	A	A	F	D	R	Y	W	R	Q	S	L	D	R	V	H	I	D	D	V	V	R	D	Y	L	Y	P	I	V	A	L	R	I	R	G	I	A	L	P	G	P	L	R	R	L	S	E	G	I	A	L	L	I
Secondary structure
SS confidence
Disorder																																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	T	G	F	L	P	Q	R	F	R	D	E	M	R	L	P	W	D	A	T	K	Q	R	R	F	D	A	L	M	A	V	L	R	T	V	N	R	L	M	P	R	F	V	R	E	F	P	F	N	L	M	L	W	D	L	D	R	R	M	R
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.	.	.	.	.	.
Sequence		R	G	R	P	L	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 18%) Alpha helix ( 70%) Beta strand ( 0%) TM helix ( 10%) (View membrane topology prediction)

Rank Aligned region

PDB 5o1m chain A Region: 46 - 280 Aligned: 224 Modelled: 235 Confidence: 99.1% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:rubber oxygenase; PDBTitle: structure of latex clearing protein lcp in the closed state Phyre2 PDB 1unh chain D Region: 130 - 197 Aligned: 68 Modelled: 68 Confidence: 34.9% Identity: 13% PDB header:cell cycle Chain: D: PDB Molecule:cyclin-dependent kinase 5 activator 1; PDBTitle: structural mechanism for the inhibition of cdk5-p25 by2 roscovitine, aloisine and indirubin. Phyre2 PDB 1unl chain D Region: 130 - 177 Aligned: 48 Modelled: 48 Confidence: 33.5% Identity: 15% Fold: Cyclin-like Superfamily: Cyclin-like Family: Cyclin Phyre2 PDB 3wkg chain A Region: 64 - 168 Aligned: 104 Modelled: 104 Confidence: 27.1% Identity: 14% PDB header:isomerase Chain: A: PDB Molecule:cellobiose 2-epimerase; PDBTitle: crystal structure of cellobiose 2-epimerase in complex with2 glucosylmannose Phyre2 PDB 1nb4 chain A Region: 72 - 128 Aligned: 57 Modelled: 57 Confidence: 26.6% Identity: 7% Fold: DNA/RNA polymerases Superfamily: DNA/RNA polymerases Family: RNA-dependent RNA-polymerase Phyre2 PDB 2ru8 chain A Region: 168 - 197 Aligned: 30 Modelled: 30 Confidence: 26.6% Identity: 13% PDB header:replication Chain: A: PDB Molecule:primosomal protein 1; PDBTitle: dnat c-terminal domain Phyre2 PDB 2vh3 chain B Region: 86 - 135 Aligned: 50 Modelled: 50 Confidence: 22.0% Identity: 20% PDB header:unknown function Chain: B: PDB Molecule:ranasmurfin; PDBTitle: ranasmurfin Phyre2 PDB 1u5t chain A domain 1 Region: 189 - 206 Aligned: 18 Modelled: 18 Confidence: 19.2% Identity: 17% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Vacuolar sorting protein domain Phyre2 PDB 4z4l chain A Region: 67 - 168 Aligned: 101 Modelled: 102 Confidence: 18.9% Identity: 14% PDB header:isomerase Chain: A: PDB Molecule:cellobiose 2-epimerase; PDBTitle: crystal structure of cellobiose 2-epimerase from caldicellulosiruptor2 saccharolyticus dsm 8903 Phyre2 PDB 5cuv chain B Region: 147 - 195 Aligned: 40 Modelled: 49 Confidence: 17.4% Identity: 5% PDB header:metal binding protein Chain: B: PDB Molecule:acidocalcisomal pyrophosphatase; PDBTitle: crystal structure of trypanosoma cruzi vacuolar soluble2 pyrophosphatases in apo form Phyre2 PDB 6aly chain A Region: 158 - 190 Aligned: 31 Modelled: 33 Confidence: 15.8% Identity: 6% PDB header:transcription Chain: A: PDB Molecule:mediator of rna polymerase ii transcription subunit 15; PDBTitle: solution structure of yeast med15 abd2 residues 277-368 Phyre2 PDB 3m20 chain A Region: 155 - 184 Aligned: 30 Modelled: 30 Confidence: 15.0% Identity: 3% PDB header:isomerase Chain: A: PDB Molecule:4-oxalocrotonate tautomerase, putative; PDBTitle: crystal structure of dmpi from archaeoglobus fulgidus determined to2 2.37 angstroms resolution Phyre2 PDB 4ou6 chain A Region: 168 - 197 Aligned: 30 Modelled: 30 Confidence: 13.7% Identity: 13% PDB header:replication/dna Chain: A: PDB Molecule:primosomal protein 1; PDBTitle: crystal structure of dnat84-153-dt10 ssdna complex form 1 Phyre2 PDB 1v7b chain A domain 2 Region: 93 - 173 Aligned: 73 Modelled: 81 Confidence: 13.4% Identity: 10% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 1g73 chain A Region: 146 - 169 Aligned: 24 Modelled: 24 Confidence: 12.7% Identity: 25% Fold: Spectrin repeat-like Superfamily: Smac/diablo Family: Smac/diablo Phyre2 PDB 3s6j chain C Region: 142 - 215 Aligned: 74 Modelled: 74 Confidence: 11.5% Identity: 3% PDB header:hydrolase Chain: C: PDB Molecule:hydrolase, haloacid dehalogenase-like family; PDBTitle: the crystal structure of a hydrolase from pseudomonas syringae Phyre2 PDB 5zhb chain B Region: 67 - 168 Aligned: 101 Modelled: 102 Confidence: 11.5% Identity: 14% PDB header:isomerase Chain: B: PDB Molecule:cellobiose 2-epimerase; PDBTitle: structure of cellobiose 2-epimerase from bacillus thermoamylovorans2 b4167 Phyre2 PDB 16vp chain A Region: 163 - 177 Aligned: 15 Modelled: 15 Confidence: 11.4% Identity: 33% Fold: Conserved core of transcriptional regulatory protein vp16 Superfamily: Conserved core of transcriptional regulatory protein vp16 Family: Conserved core of transcriptional regulatory protein vp16 Phyre2 PDB 1gyx chain A Region: 154 - 184 Aligned: 31 Modelled: 31 Confidence: 10.5% Identity: 13% Fold: Tautomerase/MIF Superfamily: Tautomerase/MIF Family: 4-oxalocrotonate tautomerase-like Phyre2 PDB 3mb2 chain J Region: 156 - 184 Aligned: 29 Modelled: 29 Confidence: 10.4% Identity: 10% PDB header:isomerase Chain: J: PDB Molecule:4-oxalocrotonate tautomerase family enzyme - beta subunit; PDBTitle: kinetic and structural characterization of a heterohexamer 4-2 oxalocrotonate tautomerase from chloroflexus aurantiacus j-10-fl:3 implications for functional and structural diversity in the4 tautomerase superfamily Phyre2 1 c5o1mA_ 2 c1unhD_ 3 d1unld_ 4 c3wkgA_ 5 d1nb4a_ 6 c2ru8A_ 7 c2vh3B_ 8 d1u5ta1 9 c4z4lA_ 10 c5cuvB_ 11 c6alyA_ 12 c3m20A_ 13 c4ou6A_ 14 d1v7ba2 15 d1g73a_ 16 c3s6jC_ 17 c5zhbB_ 18 d16vpa_ 19 d1gyxa_ 20 c3mb2J_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51