1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	A	T	P	N	A	V	E	L	T	V	D	N	A	W	F	I	A	E	T	I	G	A	G	T	F	P	W	V	L	A	I	T	M	P	Y	S	D	A	A	Q	R	G	A	F	V	D	R	Q	R	D	E	L	T	R	M	G	L	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																														?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	P	Q	G	V	I	N	P	A	V	A	D	W	I	K	V	V	C	F	P	D	R	W	L	D	L	R	Y	V	G	P	A	S	A	D	G	A	C	E	L	L	R	G	I	V	A	L	R	T	G	T	G	K	T	S	N	K	T	G	N
Secondary structure
SS confidence
Disorder		?	?	?	?																											?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	V	V	A	L	R	N	A	Q	L	V	T	F	T	A	M	D	I	D	D	P	R	A	L	V	P	I	L	G	V	G	L	A	H	R	P	P	A	R	F	D	E	F	S	L	P	T	R	V	G	A	R	A	D	E	R	L	R	S	G
Secondary structure
SS confidence
Disorder										?									?		?										?				?	?	?	?	?	?	?	?	?	?	?	?	?	?					?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	P	L	G	E	V	V	D	Y	L	G	I	P	A	S	A	R	P	V	V	E	S	V	F	S	G	P	R	S	Y	V	E	I	V	A	G	C	N	R	D	G	R	H	T	T	T	E	V	G	L	S	I	V	D	T	S	A	G	R	V
Secondary structure
SS confidence
Disorder		?	?	?							?	?	?	?	?	?											?	?	?												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.
Sequence		L	V	S	P	S	R	A	F	D	G	E	W	V	S	T	F	S	P	G	T	P	F	A	I	A	V	A	I	Q	T	L	T	A	C	L	P	D	G	Q	W	F	P	G	Q	R	V	S	R	D	F	S	T	Q	S	S
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?																											?	?	?	?	?					?		?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 33%) Beta strand ( 23%)

Rank Aligned region

PDB 4w4i chain A Region: 6 - 277 Aligned: 269 Modelled: 272 Confidence: 100.0% Identity: 100% PDB header:protein transport Chain: A: PDB Molecule:esx-3 secretion-associated protein espg3; PDBTitle: crystal structure of espg3 from the esx-3 type vii secretion system of2 m. tuberculosis Phyre2 PDB 4l4w chain B Region: 5 - 281 Aligned: 263 Modelled: 263 Confidence: 100.0% Identity: 60% PDB header:protein transport Chain: B: PDB Molecule:espg3; PDBTitle: structure of espg3 chaperone from the type vii (esx-3) secretion2 system Phyre2 PDB 4kxr chain C Region: 6 - 283 Aligned: 264 Modelled: 278 Confidence: 100.0% Identity: 20% PDB header:protein transport Chain: C: PDB Molecule:espg5; PDBTitle: structure of the mycobacterium tuberculosis type vii secretion system2 chaperone espg5 in complex with pe25-ppe41 dimer Phyre2 PDB 4rcl chain B Region: 5 - 281 Aligned: 234 Modelled: 234 Confidence: 100.0% Identity: 62% PDB header:chaperone Chain: B: PDB Molecule:espg3; PDBTitle: structure of espg3 chaperone from the type vii (esx-3) secretion2 system, space group p43212 Phyre2 PDB 5vba chain A Region: 7 - 281 Aligned: 237 Modelled: 258 Confidence: 100.0% Identity: 30% PDB header:chaperone, hydrolase Chain: A: PDB Molecule:lysozyme, esx-1 secretion-associated protein espg1 chimera; PDBTitle: structure of espg1 chaperone from the type vii (esx-1) secretion2 system determined with the assistance of n-terminal t4 lysozyme3 fusion Phyre2 PDB 1qnt chain A domain 1 Region: 265 - 288 Aligned: 24 Modelled: 24 Confidence: 27.6% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 4rdk chain B Region: 230 - 264 Aligned: 33 Modelled: 35 Confidence: 17.6% Identity: 27% PDB header:viral protein Chain: B: PDB Molecule:capsid; PDBTitle: crystal structure of norovirus boxer p domain in complex with lewis b2 tetrasaccharide Phyre2 PDB 2kim chain A Region: 264 - 288 Aligned: 25 Modelled: 25 Confidence: 15.2% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:o6-methylguanine-dna methyltransferase; PDBTitle: 1.7-mm microcryoprobe solution nmr structure of an o6-methylguanine2 dna methyltransferase family protein from vibrio parahaemolyticus.3 northeast structural genomics consortium target vpr247. Phyre2 PDB 2l3a chain A Region: 2 - 23 Aligned: 22 Modelled: 22 Confidence: 13.9% Identity: 5% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of homodimer protein sp_0782 (7-79) from2 streptococcus pneumoniae northeast structural genomics consortium3 target spr104 . Phyre2 PDB 1mgt chain A domain 1 Region: 264 - 288 Aligned: 25 Modelled: 25 Confidence: 13.8% Identity: 12% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 3ilk chain B Region: 1 - 75 Aligned: 74 Modelled: 75 Confidence: 13.1% Identity: 14% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized trna/rrna methyltransferase hi0380; PDBTitle: the structure of a probable methylase family protein from haemophilus2 influenzae rd kw20 Phyre2 PDB 3pm7 chain A Region: 2 - 23 Aligned: 22 Modelled: 19 Confidence: 12.3% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of ef_3132 protein from enterococcus faecalis at the2 resolution 2a, northeast structural genomics consortium target efr184 Phyre2 PDB 2ltd chain A Region: 2 - 23 Aligned: 22 Modelled: 22 Confidence: 11.1% Identity: 9% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ydbc; PDBTitle: solution nmr structure of apo ydbc from lactococcus lactis, northeast2 structural genomics consortium (nesg) target kr150 Phyre2 PDB 4zye chain A Region: 259 - 288 Aligned: 28 Modelled: 30 Confidence: 10.6% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:methylated-dna--protein-cysteine methyltransferase; PDBTitle: crystal structure of sulfolobus solfataricus o6-methylguanine2 methyltransferase Phyre2 PDB 3gx4 chain X Region: 264 - 288 Aligned: 25 Modelled: 25 Confidence: 10.3% Identity: 12% PDB header:dna binding protein/dna Chain: X: PDB Molecule:alkyltransferase-like protein 1; PDBTitle: crystal structure analysis of s. pombe atl in complex with dna Phyre2 PDB 3u5g chain K Region: 9 - 32 Aligned: 24 Modelled: 24 Confidence: 9.4% Identity: 17% PDB header:ribosome Chain: K: PDB Molecule:40s ribosomal protein s10-a; PDBTitle: the structure of the eukaryotic ribosome at 3.0 a resolution. this2 entry contains proteins of the 40s subunit, ribosome b Phyre2 PDB 3jcm chain K Region: 19 - 53 Aligned: 35 Modelled: 35 Confidence: 8.5% Identity: 17% PDB header:transcription Chain: K: PDB Molecule:u4/u6 small nuclear ribonucleoprotein prp3; PDBTitle: cryo-em structure of the spliceosomal u4/u6.u5 tri-snrnp Phyre2 PDB 1sfe chain A domain 1 Region: 264 - 295 Aligned: 32 Modelled: 32 Confidence: 8.4% Identity: 9% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 2ly2 chain A Region: 244 - 283 Aligned: 40 Modelled: 40 Confidence: 7.3% Identity: 23% PDB header:rna binding protein Chain: A: PDB Molecule:tudor domain-containing protein 7; PDBTitle: nmr structure of the second and third lotus domains of tudor domain-2 containing protein 7 (nmr ensemble overlay for lotus #3) Phyre2 PDB 2v4o chain B Region: 251 - 280 Aligned: 30 Modelled: 30 Confidence: 7.0% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:multifunctional protein sur e; PDBTitle: crystal structure of salmonella typhimurium sure at 2.752 angstrom resolution in monoclinic form Phyre2 1 c4w4iA_ 2 c4l4wB_ 3 c4kxrC_ 4 c4rclB_ 5 c5vbaA_ 6 d1qnta1 7 c4rdkB_ 8 c2kimA_ 9 c2l3aA_ 10 d1mgta1 11 c3ilkB_ 12 c3pm7A_ 13 c2ltdA_ 14 c4zyeA_ 15 c3gx4X_ 16 c3u5gK_ 17 c3jcmK_ 18 d1sfea1 19 c2ly2A_ 20 c2v4oB_ 21 22 23 24 25 26 27 28 29 30