1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	R	A	A	F	A	C	L	A	A	T	V	V	V	A	G	W	W	T	P	P	A	W	A	I	G	P	P	V	V	D	A	A	A	Q	P	P	S	G	D	P	G	P	V	A	P	M	E	Q	R	G	A	C	S	V	S	G	V	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?										?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	G	T	D	P	G	V	P	T	P	S	Q	T	M	L	N	L	P	A	A	W	Q	F	S	R	G	E	G	Q	L	V	A	I	I	D	T	G	V	Q	P	G	P	R	L	P	N	V	D	A	G	G	D	F	V	E	S	T	D	G	L
Secondary structure
SS confidence
Disorder		?	?	?	?																																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	D	C	D	G	H	G	T	L	V	A	G	I	V	A	G	Q	P	G	N	D	G	F	S	G	V	A	P	A	A	R	L	L	S	I	R	A	M	S	T	K	F	S	P	R	T	S	G	G	D	P	Q	L	A	Q	A	T	L	D	V
Secondary structure
SS confidence
Disorder																			?																										?	?	?	?	?	?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	L	A	G	A	I	V	H	A	A	D	L	G	A	K	V	I	N	V	S	T	I	T	C	L	P	A	D	R	M	V	D	Q	A	A	L	G	A	A	I	R	Y	A	A	V	D	K	D	A	V	I	V	A	A	A	G	N	T	G
Secondary structure
SS confidence
Disorder																											?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	S	G	S	V	S	A	S	C	D	S	N	P	L	T	D	L	S	R	P	D	D	P	R	N	W	A	G	V	T	S	V	S	I	P	S	W	W	Q	P	Y	V	L	S	V	A	S	L	T	S	A	G	Q	P	S	K	F	S	M	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?				?	?	?	?		?	?											?	?																					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	P	W	V	G	I	A	A	P	G	E	N	I	A	S	V	S	N	S	G	D	G	A	L	A	N	G	L	P	D	A	H	Q	K	L	V	A	L	S	G	T	S	Y	A	A	G	Y	V	S	G	V	A	A	L	V	R	S	R	Y	P
Secondary structure
SS confidence
Disorder																														?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	L	N	A	T	E	V	V	R	R	L	T	A	T	A	H	R	G	A	R	E	S	S	N	I	V	G	A	G	N	L	D	A	V	A	A	L	T	W	Q	L	P	A	E	P	G	G	G	A	A	P	A	K	P	V	A	D	P	P	V
Secondary structure
SS confidence
Disorder																	?	?	?		?																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.
Sequence		P	A	P	K	D	T	T	P	R	N	V	A	F	A	G	A	A	A	L	S	V	L	V	G	L	T	A	A	T	V	A	I	A	R	R	R	R	E	P	T	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?					?														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 26%) Beta strand ( 14%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 4j94 chain A Region: 26 - 410 Aligned: 375 Modelled: 385 Confidence: 100.0% Identity: 45% PDB header:hydrolase Chain: A: PDB Molecule:membrane-anchored mycosin mycp1; PDBTitle: crystal structure of mycp1 from the esx-1 type vii secretion system Phyre2 PDB 1r6v chain A Region: 20 - 406 Aligned: 344 Modelled: 359 Confidence: 100.0% Identity: 24% Fold: Subtilisin-like Superfamily: Subtilisin-like Family: Subtilases Phyre2 PDB 4kg7 chain A Region: 26 - 399 Aligned: 368 Modelled: 374 Confidence: 100.0% Identity: 65% PDB header:hydrolase Chain: A: PDB Molecule:peptidase s8 and s53, subtilisin, kexin, sedolisin; PDBTitle: structure of mycp3 protease from the type vii (esx-3) secretion2 system. Phyre2 PDB 4tr2 chain A Region: 59 - 404 Aligned: 301 Modelled: 321 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:subtilisin-like 1 serine protease; PDBTitle: crystal structure of pvsub1 Phyre2 PDB 2oxa chain A Region: 41 - 398 Aligned: 338 Modelled: 345 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:extracellular serine protease; PDBTitle: crystal structure of serine protease of aeromonas sobria Phyre2 PDB 3vta chain B Region: 72 - 401 Aligned: 309 Modelled: 311 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:cucumisin; PDBTitle: crystal structure of cucumisin, a subtilisin-like endoprotease from2 cucumis melo l Phyre2 PDB 1r64 chain A Region: 62 - 397 Aligned: 286 Modelled: 295 Confidence: 100.0% Identity: 22% PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:kexin; PDBTitle: the 2.2 a crystal structure of kex2 protease in complex with ac-arg-2 glu-lys-boroarg peptidyl boronic acid inhibitor Phyre2 PDB 3i74 chain B Region: 72 - 401 Aligned: 282 Modelled: 286 Confidence: 100.0% Identity: 32% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:subtilisin-like protease; PDBTitle: crystal structure of the plant subtilisin-like protease sbt3 in2 complex with a chloromethylketone inhibitor Phyre2 PDB 1p8j chain B Region: 59 - 397 Aligned: 291 Modelled: 297 Confidence: 100.0% Identity: 22% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:furin precursor; PDBTitle: crystal structure of the proprotein convertase furin Phyre2 PDB 1xf1 chain A Region: 72 - 397 Aligned: 283 Modelled: 290 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:c5a peptidase; PDBTitle: structure of c5a peptidase- a key virulence factor from2 streptococcus Phyre2 PDB 5xyr chain A Region: 65 - 397 Aligned: 305 Modelled: 332 Confidence: 100.0% Identity: 29% PDB header:lyase Chain: A: PDB Molecule:chemokine protease c; PDBTitle: crystal structure of a serine protease from streptococcus species Phyre2 PDB 5xxz chain B Region: 65 - 401 Aligned: 296 Modelled: 304 Confidence: 100.0% Identity: 26% PDB header:lyase Chain: B: PDB Molecule:chemokine protease c; PDBTitle: crystal structure of a serine protease from streptococcus species Phyre2 PDB 3qfh chain E Region: 49 - 400 Aligned: 322 Modelled: 322 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: E: PDB Molecule:epidermin leader peptide processing serine protease epip; PDBTitle: 2.05 angstrom resolution crystal structure of epidermin leader peptide2 processing serine protease (epip) from staphylococcus aureus. Phyre2 PDB 3t41 chain B Region: 49 - 400 Aligned: 322 Modelled: 337 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: B: PDB Molecule:epidermin leader peptide processing serine protease epip; PDBTitle: 1.95 angstrom resolution crystal structure of epidermin leader peptide2 processing serine protease (epip) s393a mutant from staphylococcus3 aureus Phyre2 PDB 6mw4 chain A Region: 69 - 397 Aligned: 305 Modelled: 329 Confidence: 100.0% Identity: 24% PDB header:signaling protein Chain: A: PDB Molecule:putative germination-specific protease; PDBTitle: structure of pseudoprotease cspc from clostridioides difficile Phyre2 PDB 3bps chain A Region: 67 - 428 Aligned: 293 Modelled: 320 Confidence: 100.0% Identity: 25% PDB header:hydrolase/lipid transport Chain: A: PDB Molecule:proprotein convertase subtilisin/kexin type 9; PDBTitle: pcsk9:egf-a complex Phyre2 PDB 4mzd chain A Region: 62 - 401 Aligned: 307 Modelled: 325 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:nisin leader peptide-processing serine protease nisp; PDBTitle: high resolution crystal structure of the nisin leader peptidase nisp2 from lactococcus lactis Phyre2 PDB 1wme chain A Region: 72 - 401 Aligned: 295 Modelled: 301 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:protease; PDBTitle: crystal structure of alkaline serine protease kp-43 from bacillus sp.2 ksm-kp43 (1.50 angstrom, 293 k) Phyre2 PDB 5vlp chain A Region: 85 - 377 Aligned: 227 Modelled: 251 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: A: PDB Molecule:proprotein convertase subtilisin/kexin type 9; PDBTitle: pcsk9 complex with ldlr antagonist peptide and fab7g7 Phyre2 PDB 1p8j chain A domain 2 Region: 59 - 400 Aligned: 294 Modelled: 300 Confidence: 100.0% Identity: 21% Fold: Subtilisin-like Superfamily: Subtilisin-like Family: Subtilases Phyre2 1 c4j94A_ 2 d1r6va_ 3 c4kg7A_ 4 c4tr2A_ 5 c2oxaA_ 6 c3vtaB_ 7 c1r64A_ 8 c3i74B_ 9 c1p8jB_ 10 c1xf1A_ 11 c5xyrA_ 12 c5xxzB_ 13 c3qfhE_ 14 c3t41B_ 15 c6mw4A_ 16 c3bpsA_ 17 c4mzdA_ 18 c1wmeA_ 19 c5vlpA_ 20 d1p8ja2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93