1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	P	I	P	S	W	P	G	R	G	R	V	T	L	V	L	L	A	V	V	P	V	A	L	A	Y	P	W	Q	S	T	R	D	Y	V	L	L	G	V	A	A	A	V	V	I	G	L	F	G	F	W	R	G	L	Y	F	T	T	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	R	R	G	L	A	I	L	R	R	R	R	R	I	A	E	P	A	T	C	T	R	T	T	V	L	V	W	V	G	P	P	A	S	D	T	N	V	L	P	L	T	L	I	A	R	Y	L	D	R	Y	G	I	R	A	D	T	I	R	I
Secondary structure
SS confidence
Disorder								?	?	?	?	?	?	?	?	?	?	?	?	?													?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		T	S	R	V	T	A	S	G	D	C	R	T	W	V	G	L	T	V	V	A	D	D	N	L	A	A	L	Q	A	R	S	A	R	I	P	L	Q	E	T	A	Q	V	A	A	R	R	L	A	D	H	L	R	E	I	G	W	E	A	G	T
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?											?	?	?	?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	P	D	E	I	P	A	L	V	A	A	D	S	R	E	T	W	R	G	M	R	H	T	D	S	D	Y	V	A	A	Y	R	V	S	A	N	A	E	L	P	D	T	L	P	A	I	R	S	R	P	A	Q	E	T	W	I	A	L	E
Secondary structure
SS confidence
Disorder		?		?	?	?	?	?					?	?	?	?	?		?			?		?	?																	?								?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	A	Y	A	A	G	S	S	T	R	Y	T	V	A	A	A	C	A	L	R	T	D	W	R	P	G	G	T	A	P	V	A	G	L	L	P	Q	H	G	N	H	V	P	A	L	T	A	L	D	P	R	S	T	R	R	L	D	G	H	T
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?														?	?	?	?	?	?		?				?	?	?			?		?	?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.
Sequence		D	A	P	A	D	L	L	T	R	L	H	W	P	T	P	T	A	G	A	H	R	A	P	L	T	N	A	V	S	R	T
Secondary structure
SS confidence
Disorder						?											?	?	?	?	?				?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 35%) Alpha helix ( 39%) Beta strand ( 19%) TM helix ( 6%) (View membrane topology prediction)

Rank Aligned region

PDB 2k42 chain B Region: 163 - 176 Aligned: 14 Modelled: 14 Confidence: 33.6% Identity: 50% PDB header:signaling protein Chain: B: PDB Molecule:espfu; PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector Phyre2 PDB 2lnh chain C Region: 163 - 176 Aligned: 14 Modelled: 14 Confidence: 28.7% Identity: 50% PDB header:signaling protein/protein binding Chain: C: PDB Molecule:secreted effector protein espf(u); PDBTitle: enterohaemorrhagic e. coli (ehec) exploits a tryptophan switch to2 hijack host f-actin assembly Phyre2 PDB 2iea chain A domain 3 Region: 98 - 119 Aligned: 22 Modelled: 22 Confidence: 12.9% Identity: 18% Fold: TK C-terminal domain-like Superfamily: TK C-terminal domain-like Family: Transketolase C-terminal domain-like Phyre2 PDB 5cdj chain A Region: 200 - 215 Aligned: 15 Modelled: 16 Confidence: 10.9% Identity: 33% PDB header:chaperone Chain: A: PDB Molecule:rubisco large subunit-binding protein subunit alpha, PDBTitle: apical domain of chloroplast chaperonin 60a Phyre2 PDB 2lgx chain A Region: 108 - 117 Aligned: 10 Modelled: 10 Confidence: 10.3% Identity: 70% PDB header:cell adhesion Chain: A: PDB Molecule:fermitin family homolog 2; PDBTitle: nmr structure for kindle-2 n-terminus Phyre2 PDB 2lzs chain E Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 10.3% Identity: 38% PDB header:protein transport Chain: E: PDB Molecule:sec-independent protein translocase protein tata; PDBTitle: tata oligomer Phyre2 PDB 1sjp chain A domain 2 Region: 200 - 215 Aligned: 15 Modelled: 16 Confidence: 10.2% Identity: 47% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 1kid chain A Region: 196 - 215 Aligned: 19 Modelled: 20 Confidence: 10.1% Identity: 26% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 1iok chain A domain 2 Region: 200 - 215 Aligned: 15 Modelled: 16 Confidence: 9.5% Identity: 40% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 1dk7 chain A Region: 200 - 215 Aligned: 15 Modelled: 16 Confidence: 9.3% Identity: 33% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 1srv chain A Region: 200 - 226 Aligned: 26 Modelled: 27 Confidence: 9.3% Identity: 23% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 1oel chain A domain 2 Region: 200 - 215 Aligned: 15 Modelled: 16 Confidence: 9.0% Identity: 33% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 1we3 chain A domain 2 Region: 200 - 215 Aligned: 15 Modelled: 16 Confidence: 8.4% Identity: 33% Fold: The "swivelling" beta/beta/alpha domain Superfamily: GroEL apical domain-like Family: GroEL-like chaperone, apical domain Phyre2 PDB 3m6c chain A Region: 200 - 226 Aligned: 26 Modelled: 27 Confidence: 8.2% Identity: 23% PDB header:chaperone Chain: A: PDB Molecule:60 kda chaperonin 1; PDBTitle: crystal structure of mycobacterium tuberculosis groel1 apical domain Phyre2 PDB 2i2x chain D Region: 87 - 181 Aligned: 79 Modelled: 79 Confidence: 7.8% Identity: 25% PDB header:transferase Chain: D: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri Phyre2 PDB 2kmc chain A Region: 108 - 116 Aligned: 9 Modelled: 9 Confidence: 7.1% Identity: 56% PDB header:cell adhesion Chain: A: PDB Molecule:fermitin family homolog 1; PDBTitle: solution structure of the n-terminal domain of kindlin-1 Phyre2 PDB 1zj8 chain A domain 2 Region: 86 - 123 Aligned: 36 Modelled: 38 Confidence: 6.7% Identity: 17% Fold: Ferredoxin-like Superfamily: Nitrite/Sulfite reductase N-terminal domain-like Family: Duplicated SiR/NiR-like domains 1 and 3 Phyre2 PDB 2hjj chain A domain 1 Region: 104 - 116 Aligned: 13 Modelled: 13 Confidence: 6.2% Identity: 46% Fold: dsRBD-like Superfamily: YcfA/nrd intein domain Family: YkfF-like Phyre2 PDB 2hjj chain A Region: 104 - 116 Aligned: 13 Modelled: 13 Confidence: 6.2% Identity: 46% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ykff; PDBTitle: solution nmr structure of protein ykff from escherichia coli.2 northeast structural genomics target er397. Phyre2 PDB 1ccw chain A Region: 87 - 177 Aligned: 75 Modelled: 75 Confidence: 5.9% Identity: 19% Fold: Flavodoxin-like Superfamily: Cobalamin (vitamin B12)-binding domain Family: Cobalamin (vitamin B12)-binding domain Phyre2 1 c2k42B_ 2 c2lnhC_ 3 d2ieaa3 4 c5cdjA_ 5 c2lgxA_ 6 c2lzsE_ 7 d1sjpa2 8 d1kida_ 9 d1ioka2 10 d1dk7a_ 11 d1srva_ 12 d1oela2 13 d1we3a2 14 c3m6cA_ 15 c2i2xD_ 16 c2kmcA_ 17 d1zj8a2 18 d2hjja1 19 c2hjjA_ 20 d1ccwa_ 21 22