1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	K	E	K	I	S	V	T	V	D	A	A	V	L	A	A	I	D	A	D	A	R	A	A	G	L	N	R	S	E	M	I	E	Q	A	L	R	N	E	H	L	R	V	A	L	R	D	Y	T	A	K	T	V	P	A	L	D	I	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?													?	?		?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.
Sequence		A	Y	A	Q	R	V	Y	Q	A	N	R	A	A	G	S
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 27%) Alpha helix ( 69%) Beta strand ( 9%)

Rank Aligned region

PDB 6g1n chain B Region: 5 - 40 Aligned: 36 Modelled: 36 Confidence: 95.0% Identity: 28% PDB header:antitoxin Chain: B: PDB Molecule:antitoxin hicb; PDBTitle: crystal structure of the burkholderia pseudomallei antitoxin hicb Phyre2 PDB 4p7d chain A Region: 5 - 40 Aligned: 36 Modelled: 36 Confidence: 94.9% Identity: 28% PDB header:toxin Chain: A: PDB Molecule:antitoxin hicb3; PDBTitle: antitoxin hicb3 crystal structure Phyre2 PDB 1q5v chain B Region: 4 - 40 Aligned: 37 Modelled: 37 Confidence: 94.5% Identity: 32% PDB header:transcription Chain: B: PDB Molecule:nickel responsive regulator; PDBTitle: apo-nikr Phyre2 PDB 2ca9 chain B Region: 5 - 40 Aligned: 36 Modelled: 36 Confidence: 94.3% Identity: 25% PDB header:transcription Chain: B: PDB Molecule:putative nickel-responsive regulator; PDBTitle: apo-nikr from helicobacter pylori in closed trans-2 conformation Phyre2 PDB 2bj3 chain D Region: 5 - 39 Aligned: 35 Modelled: 35 Confidence: 94.3% Identity: 29% PDB header:transcription Chain: D: PDB Molecule:nickel responsive regulator; PDBTitle: nikr-apo Phyre2 PDB 2hza chain A domain 1 Region: 3 - 48 Aligned: 46 Modelled: 45 Confidence: 94.2% Identity: 28% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2hza chain B domain 1 Region: 3 - 40 Aligned: 38 Modelled: 37 Confidence: 93.0% Identity: 32% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2bj7 chain A domain 1 Region: 1 - 40 Aligned: 40 Modelled: 40 Confidence: 92.8% Identity: 28% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 4me7 chain E Region: 2 - 38 Aligned: 37 Modelled: 37 Confidence: 92.7% Identity: 24% PDB header:hydrolase/hydrolase inhibitor Chain: E: PDB Molecule:antitoxin endoai; PDBTitle: crystal structure of bacillus subtilis toxin mazf in complex with2 cognate antitoxin maze Phyre2 PDB 3h87 chain D Region: 10 - 43 Aligned: 34 Modelled: 34 Confidence: 71.8% Identity: 35% PDB header:toxin/antitoxin Chain: D: PDB Molecule:putative uncharacterized protein; PDBTitle: rv0301 rv0300 toxin antitoxin complex from mycobacterium tuberculosis Phyre2 PDB 2mdv chain B Region: 8 - 39 Aligned: 32 Modelled: 32 Confidence: 70.0% Identity: 34% PDB header:de novo protein Chain: B: PDB Molecule:designed protein; PDBTitle: nmr structure of beta alpha alpha 38 Phyre2 PDB 5yrz chain C Region: 18 - 40 Aligned: 23 Modelled: 23 Confidence: 51.9% Identity: 30% PDB header:antitoxin/hydrolase Chain: C: PDB Molecule:hicb; PDBTitle: toxin-antitoxin complex from streptococcus pneumoniae Phyre2 PDB 6ajn chain F Region: 3 - 48 Aligned: 46 Modelled: 46 Confidence: 44.9% Identity: 13% PDB header:toxin Chain: F: PDB Molecule:duf1778 domain-containing protein; PDBTitle: crystal structure of atatr bound with accoa Phyre2 PDB 2k5j chain B Region: 6 - 39 Aligned: 34 Modelled: 34 Confidence: 39.1% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein yiif; PDBTitle: solution structure of protein yiif from shigella flexneri2 serotype 5b (strain 8401) . northeast structural genomics3 consortium target sft1 Phyre2 PDB 1ea4 chain K Region: 3 - 39 Aligned: 37 Modelled: 37 Confidence: 32.6% Identity: 38% PDB header:gene regulation/dna Chain: K: PDB Molecule:transcriptional repressor copg; PDBTitle: transcriptional repressor copg/22bp dsdna complex Phyre2 PDB 2cpg chain A Region: 3 - 39 Aligned: 37 Modelled: 37 Confidence: 32.6% Identity: 38% Fold: Ribbon-helix-helix Superfamily: Ribbon-helix-helix Family: CopG-like Phyre2 PDB 2k29 chain A Region: 1 - 38 Aligned: 36 Modelled: 38 Confidence: 26.1% Identity: 25% PDB header:transcription Chain: A: PDB Molecule:antitoxin relb; PDBTitle: structure of the dbd domain of e. coli antitoxin relb Phyre2 PDB 2qrv chain A Region: 42 - 70 Aligned: 29 Modelled: 29 Confidence: 24.9% Identity: 14% PDB header:transferase/transferase regulator Chain: A: PDB Molecule:dna (cytosine-5)-methyltransferase 3a; PDBTitle: structure of dnmt3a-dnmt3l c-terminal domain complex Phyre2 PDB 6gts chain C Region: 3 - 64 Aligned: 58 Modelled: 62 Confidence: 21.1% Identity: 12% PDB header:transcription Chain: C: PDB Molecule:duf1778 domain-containing protein; PDBTitle: structure of the atat-atar complex bound dna Phyre2 PDB 2c7p chain A domain 1 Region: 42 - 70 Aligned: 29 Modelled: 29 Confidence: 18.9% Identity: 41% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: C5 cytosine-specific DNA methylase, DCM Phyre2 1 c6g1nB_ 2 c4p7dA_ 3 c1q5vB_ 4 c2ca9B_ 5 c2bj3D_ 6 d2hzaa1 7 d2hzab1 8 d2bj7a1 9 c4me7E_ 10 c3h87D_ 11 c2mdvB_ 12 c5yrzC_ 13 c6ajnF_ 14 c2k5jB_ 15 c1ea4K_ 16 d2cpga_ 17 c2k29A_ 18 c2qrvA_ 19 c6gtsC_ 20 d2c7pa1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57