1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	L	L	S	D	R	D	L	R	A	E	I	S	S	G	R	L	G	I	D	P	F	D	D	T	L	V	Q	P	S	S	I	D	V	R	L	D	C	L	F	R	V	F	N	N	T	R	Y	T	H	I	D	P	A	K	Q	Q	D	E	L
Secondary structure
SS confidence
Disorder		?	?	?	?																																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		T	S	L	V	Q	P	V	D	G	E	P	F	V	L	H	P	G	E	F	V	L	G	S	T	L	E	L	F	T	L	P	D	N	L	A	G	R	L	E	G	K	S	S	L	G	R	L	G	L	L	T	H	S	T	A	G	F	I	D	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	F	S	G	H	I	T	L	E	L	S	N	V	A	N	L	P	I	T	L	W	P	G	M	K	I	G	Q	L	C	M	L	R	L	T	S	P	S	E	H	P	Y	G	S	S	R	A	G	S	K	Y	Q	G	Q	R	G	P	T	P	S
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190
Sequence		R	S	Y	Q	N	F	I	R	S	T
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 10%) Beta strand ( 39%)

Rank Aligned region

PDB 2qxx chain A Region: 1 - 189 Aligned: 189 Modelled: 189 Confidence: 100.0% Identity: 99% PDB header:hydrolase Chain: A: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase: dutpase from mycobacterium tuberculosis2 in complex with dttp Phyre2 PDB 1xs1 chain A Region: 1 - 185 Aligned: 184 Modelled: 185 Confidence: 100.0% Identity: 43% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 4xjc chain D Region: 1 - 185 Aligned: 175 Modelled: 185 Confidence: 100.0% Identity: 37% PDB header:hydrolase Chain: D: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: dctp deaminase-dutpase from bacillus halodurans Phyre2 PDB 2qlp chain C Region: 1 - 159 Aligned: 159 Modelled: 159 Confidence: 100.0% Identity: 99% PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase:dutpase from mycobacterium tuberculosis,2 apo form Phyre2 PDB 2r9q chain D Region: 2 - 156 Aligned: 154 Modelled: 155 Confidence: 100.0% Identity: 25% PDB header:hydrolase Chain: D: PDB Molecule:2'-deoxycytidine 5'-triphosphate deaminase; PDBTitle: crystal structure of 2'-deoxycytidine 5'-triphosphate deaminase from2 agrobacterium tumefaciens Phyre2 PDB 1pkh chain A Region: 1 - 166 Aligned: 165 Modelled: 166 Confidence: 100.0% Identity: 35% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2yzj chain B Region: 2 - 177 Aligned: 158 Modelled: 176 Confidence: 100.0% Identity: 25% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:167aa long hypothetical dutpase; PDBTitle: crystal structure of dctp deaminase from sulfolobus tokodaii Phyre2 PDB 3km3 chain B Region: 2 - 152 Aligned: 145 Modelled: 151 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: B: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: crystal structure of eoxycytidine triphosphate deaminase from2 anaplasma phagocytophilum at 2.1a resolution Phyre2 PDB 4dhk chain B Region: 2 - 152 Aligned: 145 Modelled: 151 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: crystal structure of a deoxycytidine triphosphate deaminase (dctp2 deaminase) from burkholderia thailandensis Phyre2 PDB 1dun chain A Region: 20 - 166 Aligned: 113 Modelled: 115 Confidence: 99.9% Identity: 28% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3mbq chain C Region: 28 - 169 Aligned: 114 Modelled: 114 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form Phyre2 PDB 1f7r chain A Region: 24 - 177 Aligned: 120 Modelled: 122 Confidence: 99.9% Identity: 32% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3ehw chain A Region: 28 - 176 Aligned: 116 Modelled: 117 Confidence: 99.9% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:dutp pyrophosphatase; PDBTitle: human dutpase in complex with alpha,beta-imido-dutp and mg2+:2 visualization of the full-length c-termini in all monomers and3 suggestion for an additional metal ion binding site Phyre2 PDB 1six chain A Region: 28 - 176 Aligned: 117 Modelled: 117 Confidence: 99.9% Identity: 29% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 6mai chain A Region: 28 - 157 Aligned: 100 Modelled: 100 Confidence: 99.9% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5'-triphosphate nucleotidohydrolase2 from legionella pneumophila philadelphia 1 Phyre2 PDB 3tqz chain A Region: 28 - 157 Aligned: 100 Modelled: 100 Confidence: 99.9% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii Phyre2 PDB 3so2 chain A Region: 28 - 176 Aligned: 116 Modelled: 117 Confidence: 99.9% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: chlorella dutpase Phyre2 PDB 3ca9 chain A Region: 15 - 157 Aligned: 109 Modelled: 111 Confidence: 99.9% Identity: 25% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 1euw chain A Region: 16 - 157 Aligned: 112 Modelled: 112 Confidence: 99.9% Identity: 24% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1rnj chain A Region: 28 - 157 Aligned: 100 Modelled: 100 Confidence: 99.9% Identity: 26% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 1 c2qxxA_ 2 d1xs1a_ 3 c4xjcD_ 4 c2qlpC_ 5 c2r9qD_ 6 d1pkha_ 7 c2yzjB_ 8 c3km3B_ 9 c4dhkB_ 10 d1duna_ 11 c3mbqC_ 12 d1f7ra_ 13 c3ehwA_ 14 d1sixa_ 15 c6maiA_ 16 c3tqzA_ 17 c3so2A_ 18 c3ca9A_ 19 d1euwa_ 20 d1rnja_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86