1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	D	A	S	V	H	P	D	E	L	D	P	E	Y	H	H	H	G	G	F	P	E	Y	G	P	A	S	P	G	A	G	F	G	Q	F	V	A	T	M	R	R	L	Q	D	L	A	V	A	A	D	P	G	D	A	V	W	D	E	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?					?					?	?	?	?		?			?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	E	R	A	A	A	L	V	E	L	L	S	P	F	E	A	D	E	G	K	A	P	A	G	R	T	P	G	L	P	G	M	G	S	L	L	L	P	P	W	T	V	T	R	Y	G	T	D	G	V	E	M	R	G	S	F	S	R	F	H
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?	?		?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	G	G	N	S	A	V	H	G	G	V	L	P	L	L	F	D	H	M	F	G	M	I	S	H	A	A	G	R	P	I	S	R	T	A	F	L	H	V	D	Y	R	R	I	T	P	I	D	V	P	L	I	V	R	G	R	V	T	N	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.
Sequence		E	G	R	K	A	F	V	C	A	E	L	F	D	S	D	E	T	L	L	A	E	G	N	G	L	M	V	R	L	L	P	G	Q	P
Secondary structure
SS confidence
Disorder																															?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 26%) Beta strand ( 30%) TM helix ( 7%) (View membrane topology prediction)

Rank Aligned region

PDB 2ov9 chain A domain 1 Region: 13 - 208 Aligned: 195 Modelled: 196 Confidence: 100.0% Identity: 24% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 4ae7 chain A Region: 43 - 213 Aligned: 169 Modelled: 171 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:thioesterase superfamily member 5; PDBTitle: crystal structure of human them5 Phyre2 PDB 4ae8 chain D Region: 43 - 210 Aligned: 164 Modelled: 165 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: D: PDB Molecule:thioesterase superfamily member 4; PDBTitle: crystal structure of human them4 Phyre2 PDB 2hbo chain A domain 1 Region: 99 - 214 Aligned: 115 Modelled: 116 Confidence: 99.9% Identity: 21% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 3f1t chain B Region: 99 - 208 Aligned: 110 Modelled: 110 Confidence: 99.9% Identity: 21% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein q9i3c8_pseae; PDBTitle: crystal structure of the q9i3c8_pseae protein from pseudomonas2 aeruginosa. northeast structural genomics consortium target par319a. Phyre2 PDB 2qwz chain B Region: 99 - 211 Aligned: 112 Modelled: 113 Confidence: 99.9% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:phenylacetic acid degradation-related protein; PDBTitle: crystal structure of a putative thioesterase (tm1040_1390) from2 silicibacter sp. tm1040 at 2.15 a resolution Phyre2 PDB 2f0x chain A domain 1 Region: 99 - 206 Aligned: 108 Modelled: 108 Confidence: 99.9% Identity: 15% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 4i82 chain A Region: 97 - 210 Aligned: 113 Modelled: 114 Confidence: 99.9% Identity: 13% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of hypothetical thioesterase protein sp_1851 from2 streptococcus pneumoniae tigr4 Phyre2 PDB 1wlu chain A domain 1 Region: 99 - 209 Aligned: 108 Modelled: 111 Confidence: 99.9% Identity: 24% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 2pim chain A Region: 96 - 207 Aligned: 110 Modelled: 111 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:phenylacetic acid degradation-related protein; PDBTitle: crystal structure of a putative thioesterase, phenylacetic acid2 degradation-related protein (reut_b4779) from ralstonia eutropha3 jmp134 at 2.20 a resolution Phyre2 PDB 3lbe chain A Region: 95 - 210 Aligned: 115 Modelled: 116 Confidence: 99.9% Identity: 15% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein smu.793; PDBTitle: the crystal structure of smu.793 from streptococcus mutans ua159 bound2 to acetyl coa Phyre2 PDB 2h4u chain A domain 1 Region: 94 - 206 Aligned: 113 Modelled: 113 Confidence: 99.9% Identity: 16% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 3e8p chain A Region: 99 - 207 Aligned: 108 Modelled: 108 Confidence: 99.9% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the protein q8e9m7 from shewanella oneidensis2 related to thioesterase superfamily. northeast structural genomics3 consortium target sor246. Phyre2 PDB 2fs2 chain A domain 1 Region: 99 - 208 Aligned: 109 Modelled: 110 Confidence: 99.9% Identity: 16% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 1zki chain A domain 1 Region: 89 - 209 Aligned: 119 Modelled: 120 Confidence: 99.9% Identity: 22% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 3nwz chain D Region: 105 - 209 Aligned: 104 Modelled: 105 Confidence: 99.9% Identity: 17% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:bh2602 protein; PDBTitle: crystal structure of bh2602 protein from bacillus halodurans with coa,2 northeast structural genomics consortium target bhr199 Phyre2 PDB 3hdu chain B Region: 100 - 209 Aligned: 109 Modelled: 110 Confidence: 99.9% Identity: 20% PDB header:hydrolase Chain: B: PDB Molecule:putative thioesterase; PDBTitle: crystal structure of a putative thioesterase (syn_01977) from2 syntrophus aciditrophicus sb at 2.50 a resolution Phyre2 PDB 2cy9 chain A domain 1 Region: 92 - 206 Aligned: 112 Modelled: 115 Confidence: 99.9% Identity: 15% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: PaaI/YdiI-like Phyre2 PDB 5hmc chain A Region: 99 - 210 Aligned: 112 Modelled: 112 Confidence: 99.9% Identity: 14% PDB header:hydrolase Chain: A: PDB Molecule:azi13; PDBTitle: crystal structure of s. sahachiroi azig complexed with 5-methyl2 naphthoic acid Phyre2 PDB 3e29 chain C Region: 99 - 207 Aligned: 108 Modelled: 107 Confidence: 99.9% Identity: 25% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein q7we92_borbr; PDBTitle: x-ray structure of the protein q7we92_borbr from thioesterase2 superfamily. northeast structural genomics consortium target bor214a. Phyre2 1 d2ov9a1 2 c4ae7A_ 3 c4ae8D_ 4 d2hboa1 5 c3f1tB_ 6 c2qwzB_ 7 d2f0xa1 8 c4i82A_ 9 d1wlua1 10 c2pimA_ 11 c3lbeA_ 12 d2h4ua1 13 c3e8pA_ 14 d2fs2a1 15 d1zkia1 16 c3nwzD_ 17 c3hduB_ 18 d2cy9a1 19 c5hmcA_ 20 c3e29C_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185