1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	A	I	V	L	I	G	A	Q	W	G	D	E	G	K	G	K	A	T	D	L	L	G	G	R	V	Q	W	V	V	R	Y	Q	G	G	N	N	A	G	H	T	V	V	L	P	T	G	E	N	F	A	L	H	L	I	P	S	G	V
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	T	P	G	V	T	N	V	I	G	N	G	V	V	I	D	P	G	V	L	L	N	E	L	R	G	L	Q	D	R	G	V	D	T	A	K	L	L	I	S	A	D	A	H	L	L	M	P	Y	H	I	A	I	D	K	V	T	E	R	Y
Secondary structure
SS confidence
Disorder																															?					?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	G	S	K	K	I	G	T	T	G	R	G	I	G	P	C	Y	Q	D	K	I	A	R	I	G	I	R	V	A	D	V	L	D	P	E	Q	L	T	H	K	V	E	A	A	C	E	F	K	N	Q	V	L	V	K	I	Y	N	R	K	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	D	P	A	Q	V	V	D	A	L	L	E	Q	A	E	G	F	K	H	R	I	A	D	T	R	L	L	L	N	A	A	L	E	A	G	E	T	V	L	L	E	G	S	Q	G	T	L	L	D	V	D	H	G	T	Y	P	Y	V	T	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	N	P	T	A	G	G	A	A	V	G	S	G	I	G	P	T	R	I	G	T	V	L	G	I	L	K	A	Y	T	T	R	V	G	S	G	P	F	P	T	E	L	F	D	E	H	G	E	Y	L	S	K	T	G	R	E	F	G	V	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	G	R	R	R	R	C	G	W	F	D	A	V	I	A	R	Y	A	A	R	V	N	G	I	T	D	Y	F	L	T	K	L	D	V	L	S	S	L	E	S	V	P	V	C	V	G	Y	E	I	D	G	R	R	T	R	D	M	P	M	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Q	R	D	L	C	R	A	K	P	V	Y	E	E	L	P	G	W	W	E	D	I	S	G	A	R	E	F	D	D	L	P	A	K	A	R	D	Y	V	L	R	L	E	Q	L	A	G	A	P	V	S	C	I	G	V	G	P	G	R	E	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.
Sequence		T	I	V	R	R	D	V	L	Q	D	R	P
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 5%) Alpha helix ( 39%) Beta strand ( 18%)

Rank Aligned region

PDB 1qf5 chain A Region: 2 - 429 Aligned: 427 Modelled: 428 Confidence: 100.0% Identity: 51% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 1dj3 chain A Region: 1 - 424 Aligned: 423 Modelled: 424 Confidence: 100.0% Identity: 46% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 1dj2 chain A Region: 1 - 424 Aligned: 423 Modelled: 424 Confidence: 100.0% Identity: 44% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 1iwe chain A Region: 1 - 424 Aligned: 419 Modelled: 424 Confidence: 100.0% Identity: 44% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 1iwe chain B Region: 1 - 424 Aligned: 419 Modelled: 424 Confidence: 100.0% Identity: 44% PDB header:ligase Chain: B: PDB Molecule:adenylosuccinate synthetase; PDBTitle: imp complex of the recombinant mouse-muscle adenylosuccinate2 synthetase Phyre2 PDB 1p9b chain A Region: 2 - 425 Aligned: 417 Modelled: 424 Confidence: 100.0% Identity: 41% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 4m0g chain B Region: 1 - 429 Aligned: 416 Modelled: 428 Confidence: 100.0% Identity: 49% PDB header:ligase Chain: B: PDB Molecule:adenylosuccinate synthetase; PDBTitle: the crystal structure of an adenylosuccinate synthetase from bacillus2 anthracis str. ames ancestor. Phyre2 PDB 5i34 chain B Region: 3 - 424 Aligned: 407 Modelled: 422 Confidence: 100.0% Identity: 43% PDB header:ligase Chain: B: PDB Molecule:adenylosuccinate synthetase; PDBTitle: adenylosuccinate synthetase from cryptococcus neoformans complexed2 with gdp and imp Phyre2 PDB 3ue9 chain A Region: 2 - 429 Aligned: 411 Modelled: 428 Confidence: 100.0% Identity: 46% PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of adenylosuccinate synthetase (ampsase) (pura) from2 burkholderia thailandensis Phyre2 PDB 3r7t chain A Region: 2 - 424 Aligned: 406 Modelled: 423 Confidence: 100.0% Identity: 45% PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of adenylosuccinate synthetase from campylobacter2 jejuni Phyre2 PDB 6bs7 chain A Region: 1 - 428 Aligned: 386 Modelled: 398 Confidence: 100.0% Identity: 46% PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of adenylosuccinate synthetase from legionella2 pneumophila philadelphia 1 Phyre2 PDB 2d7u chain A Region: 1 - 426 Aligned: 319 Modelled: 323 Confidence: 100.0% Identity: 43% PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of hypothetical adenylosuccinate synthetase, ph04382 from pyrococcus horikoshii ot3 Phyre2 PDB 6fm0 chain A Region: 2 - 427 Aligned: 290 Modelled: 301 Confidence: 100.0% Identity: 27% PDB header:biosynthetic protein Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: deoxyguanylosuccinate synthase (dgss) and atp structure at 1.72 angstrom resolution Phyre2 PDB 1a0i chain A domain 1 Region: 6 - 39 Aligned: 34 Modelled: 34 Confidence: 89.4% Identity: 24% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: DNA ligase/mRNA capping enzyme postcatalytic domain Phyre2 PDB 3knu chain D Region: 70 - 151 Aligned: 77 Modelled: 82 Confidence: 68.1% Identity: 17% PDB header:transferase Chain: D: PDB Molecule:trna (guanine-n(1)-)-methyltransferase; PDBTitle: crystal structure of trna (guanine-n1)-methyltransferase from2 anaplasma phagocytophilum Phyre2 PDB 1p9p chain A Region: 70 - 151 Aligned: 77 Modelled: 77 Confidence: 59.1% Identity: 21% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: tRNA(m1G37)-methyltransferase TrmD Phyre2 PDB 1ual chain A Region: 70 - 151 Aligned: 77 Modelled: 77 Confidence: 55.8% Identity: 22% Fold: alpha/beta knot Superfamily: alpha/beta knot Family: tRNA(m1G37)-methyltransferase TrmD Phyre2 PDB 1zgx chain A Region: 380 - 403 Aligned: 24 Modelled: 24 Confidence: 51.3% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:guanyl-specific ribonuclease sa; PDBTitle: crystal structure of ribonuclease mutant Phyre2 PDB 1qwd chain A Region: 14 - 103 Aligned: 86 Modelled: 90 Confidence: 48.1% Identity: 19% Fold: Lipocalins Superfamily: Lipocalins Family: Retinol binding protein-like Phyre2 PDB 2f09 chain A domain 1 Region: 20 - 60 Aligned: 38 Modelled: 41 Confidence: 45.5% Identity: 16% Fold: Streptavidin-like Superfamily: YdhA-like Family: YdhA-like Phyre2 1 d1qf5a_ 2 d1dj3a_ 3 d1dj2a_ 4 d1iwea_ 5 c1iweB_ 6 d1p9ba_ 7 c4m0gB_ 8 c5i34B_ 9 c3ue9A_ 10 c3r7tA_ 11 c6bs7A_ 12 c2d7uA_ 13 c6fm0A_ 14 d1a0ia1 15 c3knuD_ 16 d1p9pa_ 17 d1uala_ 18 c1zgxA_ 19 d1qwda_ 20 d2f09a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99