1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	T	A	V	T	A	M	P	D	I	L	D	P	M	Y	W	L	G	A	N	G	V	F	G	S	A	V	L	P	G	I	L	I	I	V	F	I	E	T	G	L	L	F	P	L	L	P	G	E	S	L	L	F	T	G	G	L	L	S
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	S	P	A	P	P	V	T	I	G	V	L	A	P	C	V	A	L	V	A	V	L	G	D	Q	T	A	Y	F	I	G	R	R	I	G	P	A	L	F	K	K	E	D	S	R	F	F	K	K	H	Y	V	T	E	S	H	A	F	F	E
Secondary structure
SS confidence
Disorder																																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	Y	G	K	W	T	I	I	L	A	R	F	V	P	I	A	R	T	F	V	P	V	I	A	G	V	S	Y	M	R	Y	P	V	F	L	G	F	D	I	V	G	G	V	A	W	G	A	G	V	T	L	A	G	Y	F	L	G	S	V	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.
Sequence		F	V	H	M	N	F	Q	L	I	I	L	A	I	V	F	V	S	L	L	P	A	L	V	S	A	A	R	V	Y	R	A	R	R	N	A	P	Q	S	D	P	D	P	L	V	L	P	E
Secondary structure
SS confidence
Disorder																																?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 10%) Alpha helix ( 80%) Beta strand ( 0%) TM helix ( 54%) (View membrane topology prediction)

Rank Aligned region

PDB 4dji chain A Region: 148 - 227 Aligned: 80 Modelled: 80 Confidence: 55.5% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:probable glutamate/gamma-aminobutyrate antiporter; PDBTitle: structure of glutamate-gaba antiporter gadc Phyre2 PDB 6adq chain P Region: 145 - 214 Aligned: 62 Modelled: 70 Confidence: 50.4% Identity: 21% PDB header:electron transport Chain: P: PDB Molecule:prokaryotic respiratory supercomplex associate factor 1 PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 6nbx chain G Region: 176 - 227 Aligned: 52 Modelled: 52 Confidence: 43.4% Identity: 15% PDB header:oxidoreductase Chain: G: PDB Molecule:nadh-quinone oxidoreductase subunit j; PDBTitle: t.elongatus ndh (data-set 2) Phyre2 PDB 1fft chain B domain 2 Region: 177 - 221 Aligned: 45 Modelled: 45 Confidence: 29.5% Identity: 20% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 4ev6 chain E Region: 153 - 210 Aligned: 58 Modelled: 58 Confidence: 28.6% Identity: 10% PDB header:metal transport Chain: E: PDB Molecule:magnesium transport protein cora; PDBTitle: the complete structure of cora magnesium transporter from2 methanocaldococcus jannaschii Phyre2 PDB 3ukx chain C Region: 209 - 224 Aligned: 16 Modelled: 16 Confidence: 27.7% Identity: 25% PDB header:protein transport/inhibitor Chain: C: PDB Molecule:bimax2 peptide; PDBTitle: mouse importin alpha: bimax2 peptide complex Phyre2 PDB 2knc chain A Region: 187 - 221 Aligned: 35 Modelled: 35 Confidence: 27.5% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2jln chain A Region: 66 - 226 Aligned: 153 Modelled: 161 Confidence: 24.4% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 5n9y chain B Region: 109 - 210 Aligned: 101 Modelled: 102 Confidence: 20.8% Identity: 13% PDB header:membrane protein Chain: B: PDB Molecule:zinc transport protein zntb; PDBTitle: the full-length structure of zntb Phyre2 PDB 2na6 chain A Region: 190 - 214 Aligned: 25 Modelled: 25 Confidence: 19.3% Identity: 32% PDB header:apoptosis Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 2na6 chain B Region: 190 - 214 Aligned: 25 Modelled: 25 Confidence: 19.3% Identity: 32% PDB header:apoptosis Chain: B: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 2na6 chain C Region: 190 - 214 Aligned: 25 Modelled: 25 Confidence: 19.3% Identity: 32% PDB header:apoptosis Chain: C: PDB Molecule:tumor necrosis factor receptor superfamily member 6; PDBTitle: transmembrane domain of mouse fas/cd95 death receptor Phyre2 PDB 4q2e chain A Region: 70 - 222 Aligned: 110 Modelled: 113 Confidence: 18.5% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:phosphatidate cytidylyltransferase; PDBTitle: crystal structure of an intramembrane cdp-dag synthetase central for2 phospholipid biosynthesis (s200c/s258c, active mutant) Phyre2 PDB 2vv5 chain A domain 3 Region: 76 - 146 Aligned: 70 Modelled: 71 Confidence: 16.4% Identity: 16% Fold: Mechanosensitive channel protein MscS (YggB), transmembrane region Superfamily: Mechanosensitive channel protein MscS (YggB), transmembrane region Family: Mechanosensitive channel protein MscS (YggB), transmembrane region Phyre2 PDB 2bbj chain B Region: 112 - 210 Aligned: 67 Modelled: 67 Confidence: 16.1% Identity: 15% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 2jp3 chain A Region: 185 - 225 Aligned: 41 Modelled: 41 Confidence: 14.6% Identity: 17% PDB header:transcription Chain: A: PDB Molecule:fxyd domain-containing ion transport regulator 4; PDBTitle: solution structure of the human fxyd4 (chif) protein in sds2 micelles Phyre2 PDB 5xsy chain B Region: 188 - 218 Aligned: 31 Modelled: 31 Confidence: 14.2% Identity: 6% PDB header:membrane protein Chain: B: PDB Molecule:voltage-gated sodium channel beta subunit 1; PDBTitle: structure of the nav1.4-beta1 complex from electric eel Phyre2 PDB 2oar chain A domain 1 Region: 155 - 227 Aligned: 73 Modelled: 73 Confidence: 12.9% Identity: 8% Fold: Gated mechanosensitive channel Superfamily: Gated mechanosensitive channel Family: Gated mechanosensitive channel Phyre2 PDB 3dtu chain B domain 2 Region: 177 - 219 Aligned: 43 Modelled: 43 Confidence: 11.0% Identity: 16% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 6hwh chain L Region: 177 - 221 Aligned: 45 Modelled: 45 Confidence: 10.8% Identity: 7% PDB header:electron transport Chain: L: PDB Molecule:cytochrome c oxidase subunit 2; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 1 c4djiA_ 2 c6adqP_ 3 c6nbxG_ 4 d1fftb2 5 c4ev6E_ 6 c3ukxC_ 7 c2kncA_ 8 c2jlnA_ 9 c5n9yB_ 10 c2na6A_ 11 c2na6B_ 12 c2na6C_ 13 c4q2eA_ 14 d2vv5a3 15 c2bbjB_ 16 c2jp3A_ 17 c5xsyB_ 18 d2oara1 19 d3dtub2 20 c6hwhL_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41