1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	T	P	A	L	L	P	G	V	D	L	A	A	F	A	A	A	L	A	A	R	L	R	D	A	G	I	P	V	S	A	S	G	Q	A	S	L	V	Q	A	L	Q	Q	L	V	P	R	T	P	A	A	L	Y	W	G	A	R	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	S	R	V	D	E	L	A	T	F	D	A	V	F	A	S	L	F	G	V	F	G	S	A	E	P	D	G	A	N	R	P	P	P	P	I	A	G	P	R	T	P	V	A	G	V	G	H	R	A	K	R	R	S	C	A	A	Q	A
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		Q	N	L	P	W	D	T	R	S	L	T	M	A	S	A	G	Q	G	G	P	S	R	T	L	P	D	V	L	P	S	R	I	V	A	R	A	D	E	P	F	D	Q	F	D	P	D	D	L	R	L	L	G	A	W	L	E	A	T	M	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	W	P	R	R	R	S	M	R	F	E	S	S	P	H	G	K	R	I	D	L	R	A	T	M	N	A	S	R	S	T	G	W	E	S	V	L	L	A	R	I	R	P	R	R	R	P	R	R	V	L	L	L	C	D	V	S	R	S	M
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?	?	?	?	?	?																						?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Q	P	Y	A	A	I	Y	L	R	L	M	R	A	A	V	L	R	R	A	G	G	H	P	E	V	F	A	F	S	T	S	L	T	R	L	T	S	V	L	S	H	R	S	A	E	M	A	L	H	R	A	N	A	R	V	T	D	R	Y	G
Secondary structure
SS confidence
Disorder																	?	?	?																																				?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	T	F	I	G	R	S	V	A	A	L	L	A	P	P	H	G	N	A	L	R	G	A	V	V	I	I	A	S	D	G	W	D	S	D	P	P	D	V	L	V	H	A	L	T	R	V	R	R	R	A	E	L	L	V	W	L	N	P	R
Secondary structure
SS confidence
Disorder																		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.
Sequence		A	A	H	P	E	F	Q	P	R	A	G	S	M	A	A	A	L	P	Y	C	D	L	F	L	P	A	H	S	L	A	G	L	H	Q	L	L	L	A	L	A	G	A	R
Secondary structure
SS confidence
Disorder																																								?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 30%) Alpha helix ( 51%) Beta strand ( 7%)

Rank Aligned region

PDB 4fx5 chain A Region: 212 - 355 Aligned: 144 Modelled: 144 Confidence: 99.2% Identity: 15% PDB header:blood clotting Chain: A: PDB Molecule:von willebrand factor type a; PDBTitle: von willebrand factor type a from catenulispora acidiphila Phyre2 PDB 3ibs chain A Region: 226 - 357 Aligned: 130 Modelled: 132 Confidence: 99.2% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein batb; PDBTitle: crystal structure of conserved hypothetical protein batb from2 bacteroides thetaiotaomicron Phyre2 PDB 6fpz chain A Region: 224 - 352 Aligned: 129 Modelled: 129 Confidence: 99.1% Identity: 14% PDB header:structural protein Chain: A: PDB Molecule:inter-alpha-trypsin inhibitor heavy chain h1; PDBTitle: inter-alpha-inhibitor heavy chain 1, d298a Phyre2 PDB 5iy7 chain 0 Region: 223 - 401 Aligned: 172 Modelled: 179 Confidence: 99.1% Identity: 9% PDB header:transcription, transferase/dna Chain: 0: PDB Molecule:general transcription factor iih subunit 2; PDBTitle: human holo-pic in the open state Phyre2 PDB 4wfq chain A Region: 223 - 400 Aligned: 171 Modelled: 178 Confidence: 99.0% Identity: 11% PDB header:transcription Chain: A: PDB Molecule:suppressor of stem-loop protein 1; PDBTitle: crystal structure of tfiih subunit Phyre2 PDB 2i6s chain A Region: 219 - 349 Aligned: 130 Modelled: 131 Confidence: 99.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:complement c2a fragment; PDBTitle: complement component c2a Phyre2 PDB 1yvr chain A domain 2 Region: 224 - 356 Aligned: 125 Modelled: 129 Confidence: 99.0% Identity: 19% Fold: vWA-like Superfamily: vWA-like Family: RoRNP C-terminal domain-like Phyre2 PDB 2ok5 chain A domain 1 Region: 215 - 352 Aligned: 136 Modelled: 135 Confidence: 99.0% Identity: 15% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 1rs0 chain A Region: 229 - 349 Aligned: 120 Modelled: 121 Confidence: 98.9% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: crystal structure analysis of the bb segment of factor b2 complexed with di-isopropyl-phosphate (dip) Phyre2 PDB 2x31 chain F Region: 223 - 343 Aligned: 118 Modelled: 121 Confidence: 98.9% Identity: 12% PDB header:ligase Chain: F: PDB Molecule:magnesium-chelatase 60 kda subunit; PDBTitle: modelling of the complex between subunits bchi and bchd of magnesium2 chelatase based on single-particle cryo-em reconstruction at 7.5 ang Phyre2 PDB 6o9l chain 6 Region: 228 - 355 Aligned: 128 Modelled: 128 Confidence: 98.9% Identity: 10% PDB header:transcription/dna Chain: 6: PDB Molecule:general transcription factor iih subunit 2; PDBTitle: human holo-pic in the closed state Phyre2 PDB 6nmi chain E Region: 228 - 355 Aligned: 128 Modelled: 128 Confidence: 98.9% Identity: 11% PDB header:transcription Chain: E: PDB Molecule:general transcription factor iih subunit 2, p44; PDBTitle: cryo-em structure of the human tfiih core complex Phyre2 PDB 2ok5 chain A Region: 229 - 352 Aligned: 122 Modelled: 121 Confidence: 98.9% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:complement factor b; PDBTitle: human complement factor b Phyre2 PDB 2nvo chain A Region: 224 - 357 Aligned: 126 Modelled: 134 Confidence: 98.8% Identity: 17% PDB header:rna binding protein Chain: A: PDB Molecule:ro sixty-related protein, rsr; PDBTitle: crystal structure of deinococcus radiodurans ro (rsr) protein Phyre2 PDB 4rck chain B Region: 226 - 357 Aligned: 129 Modelled: 132 Confidence: 98.8% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:hypothetical membrane spanning protein; PDBTitle: crystal structure of uncharacterized membrane spanning protein from2 vibrio fischeri Phyre2 PDB 5a8j chain A Region: 225 - 338 Aligned: 106 Modelled: 114 Confidence: 98.8% Identity: 16% PDB header:transcription Chain: A: PDB Molecule:vwa2; PDBTitle: crystal structure of the arnb paralog vwa2 from2 sulfolobus acidocaldarius Phyre2 PDB 4hqn chain B Region: 225 - 355 Aligned: 130 Modelled: 131 Confidence: 98.8% Identity: 16% PDB header:cell adhesion Chain: B: PDB Molecule:sporozoite surface protein 2; PDBTitle: crystal structure of manganese-loaded plasmodium vivax trap protein Phyre2 PDB 4oku chain A Region: 225 - 355 Aligned: 130 Modelled: 131 Confidence: 98.8% Identity: 15% PDB header:cell adhesion Chain: A: PDB Molecule:micronemal protein mic2; PDBTitle: structure of toxoplasma gondii promic2 Phyre2 PDB 1v7p chain C Region: 229 - 355 Aligned: 126 Modelled: 127 Confidence: 98.7% Identity: 14% Fold: vWA-like Superfamily: vWA-like Family: Integrin A (or I) domain Phyre2 PDB 2xgg chain B Region: 225 - 355 Aligned: 130 Modelled: 131 Confidence: 98.7% Identity: 15% PDB header:hydrolase Chain: B: PDB Molecule:microneme protein 2; PDBTitle: structure of toxoplasma gondii micronemal protein 2 a_i2 domain Phyre2 1 c4fx5A_ 2 c3ibsA_ 3 c6fpzA_ 4 c5iy70_ 5 c4wfqA_ 6 c2i6sA_ 7 d1yvra2 8 d2ok5a1 9 c1rs0A_ 10 c2x31F_ 11 c6o9l6_ 12 c6nmiE_ 13 c2ok5A_ 14 c2nvoA_ 15 c4rckB_ 16 c5a8jA_ 17 c4hqnB_ 18 c4okuA_ 19 d1v7pc_ 20 c2xggB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131