1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	I	L	V	A	W	A	T	C	G	A	V	V	L	S	G	L	T	G	C	S	G	S	S	H	S	G	R	T	Y	G	A	Q	S	A	R	T	G	E	S	L	A	V	L	G	W	N	M	S	V	S	N	L	R	W	S	G	D	Y
Secondary structure
SS confidence
Disorder		?						?			?										?	?	?						?		?			?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	L	I	D	V	D	A	S	P	T	D	P	H	A	P	H	A	K	P	E	D	I	R	F	G	L	Y	G	A	L	A	H	P	M	E	S	A	A	L	G	S	C	G	D	A	M	A	H	V	R	D	V	V	S	P	L	S	A	P	A
Secondary structure
SS confidence
Disorder									?		?	?	?	?	?	?	?	?	?																				?	?		?										?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	R	L	T	G	T	V	C	L	G	P	L	K	E	R	S	A	V	R	G	V	Y	T	Y	S	P	R	D	R	I	P	G	T	A	A	A	Y	P	A	A	F	P	V	G	M	L	P	T	N	Q	N	D	A	G	L	V	V	K	T	T
Secondary structure
SS confidence
Disorder		?												?	?																	?	?	?		?																									?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	V	S	A	W	R	A	D	G	M	Q	L	G	K	P	Q	L	G	D	P	V	A	F	T	G	N	G	Y	M	L	L	G	L	E	V	D	A	V	P	D	R	Y	R	D	D	S	A	A	R	G	G	P	M	M	L	L	A	A	P	T
Secondary structure
SS confidence
Disorder		?	?	?	?		?	?	?		?	?	?	?	?	?	?	?																											?	?	?	?	?									?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	P	G	R	G	L	S	P	A	C	A	T	Y	G	S	S	V	L	I	L	P	D	A	L	L	D	A	V	H	I	S	A	S	L	C	T	Q	G	E	I	N	E	A	L	L	Y	A	T	V	A	T	V	G	T	H	A	A	L	W	T
Secondary structure
SS confidence
Disorder		?	?	?	?																			?		?					?						?															?					?	?	?	?	?
Disorder confidence
		.	.
Sequence		S	R
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 8%) Beta strand ( 49%)

Rank Aligned region

PDB 3c0n chain A domain 2 Region: 54 - 118 Aligned: 63 Modelled: 65 Confidence: 46.5% Identity: 25% Fold: Aerolisin/ETX pore-forming domain Superfamily: Aerolisin/ETX pore-forming domain Family: (Pro)aerolysin, pore-forming lobe Phyre2 PDB 1urz chain C Region: 21 - 91 Aligned: 67 Modelled: 70 Confidence: 32.5% Identity: 18% PDB header:virus/viral protein Chain: C: PDB Molecule:envelope protein; PDBTitle: low ph induced, membrane fusion conformation of the2 envelope protein of tick-borne encephalitis virus Phyre2 PDB 4iao chain B Region: 39 - 111 Aligned: 52 Modelled: 59 Confidence: 24.7% Identity: 37% PDB header:hydrolase/transcription Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of sir2 c543s mutant in complex with sid domain of2 sir4 Phyre2 PDB 1ok8 chain A domain 2 Region: 21 - 91 Aligned: 66 Modelled: 70 Confidence: 14.8% Identity: 20% Fold: Viral glycoprotein, central and dimerisation domains Superfamily: Viral glycoprotein, central and dimerisation domains Family: Viral glycoprotein, central and dimerisation domains Phyre2 PDB 1qcs chain A domain 1 Region: 57 - 86 Aligned: 30 Modelled: 30 Confidence: 13.3% Identity: 27% Fold: Double psi beta-barrel Superfamily: ADC-like Family: Cdc48 N-terminal domain-like Phyre2 PDB 1svb chain A domain 2 Region: 21 - 91 Aligned: 67 Modelled: 70 Confidence: 11.7% Identity: 21% Fold: Viral glycoprotein, central and dimerisation domains Superfamily: Viral glycoprotein, central and dimerisation domains Family: Viral glycoprotein, central and dimerisation domains Phyre2 PDB 5ire chain A Region: 21 - 91 Aligned: 67 Modelled: 70 Confidence: 11.5% Identity: 22% PDB header:virus Chain: A: PDB Molecule:e protein; PDBTitle: the cryo-em structure of zika virus Phyre2 PDB 6bi6 chain A Region: 53 - 120 Aligned: 55 Modelled: 68 Confidence: 8.4% Identity: 24% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein yejg; PDBTitle: solution nmr structure of uncharacterized protein yejg Phyre2 PDB 1i40 chain A Region: 148 - 205 Aligned: 41 Modelled: 41 Confidence: 7.3% Identity: 29% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 4o4d chain A Region: 253 - 287 Aligned: 35 Modelled: 35 Confidence: 7.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:inositol hexakisphosphate kinase; PDBTitle: crystal structure of an inositol hexakisphosphate kinase ehip6ka in2 complexed with atp and ins(1,4,5)p3 Phyre2 PDB 2hjh chain B Region: 39 - 109 Aligned: 50 Modelled: 48 Confidence: 7.0% Identity: 32% PDB header:hydrolase Chain: B: PDB Molecule:nad-dependent histone deacetylase sir2; PDBTitle: crystal structure of the sir2 deacetylase Phyre2 PDB 2erl chain A Region: 273 - 279 Aligned: 7 Modelled: 7 Confidence: 7.0% Identity: 86% Fold: Protozoan pheromone-like Superfamily: Protozoan pheromone proteins Family: Protozoan pheromone proteins Phyre2 PDB 2cu9 chain A domain 1 Region: 112 - 133 Aligned: 22 Modelled: 22 Confidence: 6.8% Identity: 27% Fold: Immunoglobulin-like beta-sandwich Superfamily: ASF1-like Family: ASF1-like Phyre2 PDB 1roc chain A Region: 112 - 133 Aligned: 22 Modelled: 22 Confidence: 6.6% Identity: 23% Fold: Immunoglobulin-like beta-sandwich Superfamily: ASF1-like Family: ASF1-like Phyre2 PDB 4drb chain C Region: 144 - 186 Aligned: 40 Modelled: 43 Confidence: 6.5% Identity: 20% PDB header:dna binding protein/protein binding Chain: C: PDB Molecule:fanconi anemia group m protein; PDBTitle: the crystal structure of fancm bound mhf complex Phyre2 PDB 3uaj chain A Region: 21 - 91 Aligned: 67 Modelled: 71 Confidence: 6.5% Identity: 21% PDB header:viral protein/immune system Chain: A: PDB Molecule:envelope protein; PDBTitle: crystal structure of the envelope glycoprotein ectodomain from dengue2 virus serotype 4 in complex with the fab fragment of the chimpanzee3 monoclonal antibody 5h2 Phyre2 PDB 2z1c chain A domain 1 Region: 58 - 66 Aligned: 9 Modelled: 9 Confidence: 6.2% Identity: 33% Fold: OB-fold Superfamily: HupF/HypC-like Family: HupF/HypC-like Phyre2 PDB 2idc chain A Region: 112 - 133 Aligned: 22 Modelled: 22 Confidence: 6.1% Identity: 23% PDB header:replication/chaperone Chain: A: PDB Molecule:anti-silencing protein 1 and histone h3 chimera; PDBTitle: structure of the histone h3-asf1 chaperone interaction Phyre2 PDB 3j21 chain R Region: 58 - 68 Aligned: 11 Modelled: 11 Confidence: 5.9% Identity: 36% PDB header:ribosome Chain: R: PDB Molecule:50s ribosomal protein l21e; PDBTitle: promiscuous behavior of proteins in archaeal ribosomes revealed by2 cryo-em: implications for evolution of eukaryotic ribosomes (50s3 ribosomal proteins) Phyre2 PDB 5vqj chain A Region: 184 - 214 Aligned: 29 Modelled: 31 Confidence: 5.9% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:exo-beta-1,4-xylanase; PDBTitle: discovery of a first gh11 exo-1,4-beta-xylanase from a diverse2 microbial sugar cane bagasse composting community Phyre2 1 d3c0na2 2 c1urzC_ 3 c4iaoB_ 4 d1ok8a2 5 d1qcsa1 6 d1svba2 7 c5ireA_ 8 c6bi6A_ 9 d1i40a_ 10 c4o4dA_ 11 c2hjhB_ 12 d2erla_ 13 d2cu9a1 14 d1roca_ 15 c4drbC_ 16 c3uajA_ 17 d2z1ca1 18 c2idcA_ 19 c3j21R_ 20 c5vqjA_ 21 22 23 24 25 26 27 28 29 30 31 32 33