1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	P	S	C	P	P	A	Y	S	E	Q	V	R	G	D	G	D	G	W	V	V	S	D	S	G	V	A	Y	W	G	R	Y	G	A	A	G	L	L	L	R	A	P	R	P	D	G	T	P	A	V	L	L	Q	H	R	A	L	W	S	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	G	G	T	W	G	L	P	G	G	A	R	D	S	H	E	T	P	E	Q	T	A	V	R	E	S	S	E	E	A	G	L	S	A	E	R	L	E	V	R	A	T	V	V	T	A	E	V	C	G	V	D	D	T	H	W	T	Y	T	T
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	A	D	A	G	E	L	L	D	T	V	P	N	R	E	S	A	E	L	R	W	V	A	E	N	E	V	A	D	L	P	L	H	P	G	F	A	A	S	W	Q	R	L	R	T	A	P	A	T	V	P	L	A	R	C	D	E	R	R
Secondary structure
SS confidence
Disorder																																																							?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.
Sequence		Q	R	L	P	R	T	I	Q	I	E	A	G	V	F	L	W	C	T	P	G	D	A	D	Q	A	P	S	P	L	G	R	R	I	S	S	L	L
Secondary structure
SS confidence
Disorder					?	?																?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 21%) Beta strand ( 26%) TM helix ( 7%) (View membrane topology prediction)

Rank Aligned region

PDB 2gb5 chain B Region: 2 - 161 Aligned: 148 Modelled: 160 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: B: PDB Molecule:nadh pyrophosphatase; PDBTitle: crystal structure of nadh pyrophosphatase (ec 3.6.1.22) (1790429) from2 escherichia coli k12 at 2.30 a resolution Phyre2 PDB 6o3p chain A Region: 2 - 165 Aligned: 154 Modelled: 164 Confidence: 99.9% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:peroxisomal nadh pyrophosphatase nudt12; PDBTitle: crystal structure of the catalytic domain of mouse nudt12 in complex2 with amp and 3 mg2+ ions Phyre2 PDB 3cng chain C Region: 2 - 165 Aligned: 152 Modelled: 163 Confidence: 99.9% Identity: 25% PDB header:hydrolase Chain: C: PDB Molecule:nudix hydrolase; PDBTitle: crystal structure of nudix hydrolase from nitrosomonas europaea Phyre2 PDB 5gg7 chain A Region: 34 - 170 Aligned: 126 Modelled: 137 Confidence: 99.8% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:hydrolase, nudix family protein; PDBTitle: crystal structure of mycobacterium smegmatis mutt1 in complex with 8-2 oxo-dgtp, 8-oxo-dgmp and pyrophosphate (i) Phyre2 PDB 1ktg chain A Region: 34 - 165 Aligned: 128 Modelled: 132 Confidence: 99.8% Identity: 21% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 3gz8 chain C Region: 23 - 165 Aligned: 140 Modelled: 143 Confidence: 99.8% Identity: 19% PDB header:dna binding protein Chain: C: PDB Molecule:mutt/nudix family protein; PDBTitle: cocrystal structure of nudix domain of shewanella oneidensis nrtr2 complexed with adp ribose Phyre2 PDB 3hhj chain A Region: 34 - 165 Aligned: 128 Modelled: 132 Confidence: 99.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:mutator mutt protein; PDBTitle: crystal structure of mutator mutt from bartonella henselae Phyre2 PDB 3fk9 chain B Region: 31 - 191 Aligned: 152 Modelled: 161 Confidence: 99.8% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:mutator mutt protein; PDBTitle: crystal structure of mmutator mutt protein from bacillus halodurans Phyre2 PDB 2pq1 chain B Region: 34 - 165 Aligned: 121 Modelled: 132 Confidence: 99.8% Identity: 26% PDB header:hydrolase Chain: B: PDB Molecule:ap4a hydrolase; PDBTitle: crystal structure of ap4a hydrolase complexed with amp and2 atp (aq_158) from aquifex aeolicus vf5 Phyre2 PDB 1sjy chain A Region: 22 - 164 Aligned: 136 Modelled: 142 Confidence: 99.8% Identity: 24% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 2rrk chain A Region: 35 - 172 Aligned: 128 Modelled: 138 Confidence: 99.8% Identity: 24% PDB header:hydrolase Chain: A: PDB Molecule:ctp pyrophosphohydrolase; PDBTitle: solution structure of the e. coli orf135 protein Phyre2 PDB 3exq chain A Region: 30 - 164 Aligned: 131 Modelled: 135 Confidence: 99.8% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:nudix family hydrolase; PDBTitle: crystal structure of a nudix family hydrolase from2 lactobacillus brevis Phyre2 PDB 2fb1 chain A domain 2 Region: 34 - 153 Aligned: 116 Modelled: 120 Confidence: 99.8% Identity: 19% Fold: Nudix Superfamily: Nudix Family: BT0354 N-terminal domain-like Phyre2 PDB 3q4i chain A Region: 30 - 164 Aligned: 125 Modelled: 129 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:phosphohydrolase (mutt/nudix family protein); PDBTitle: crystal structure of cdp-chase in complex with gd3+ Phyre2 PDB 3i9x chain A Region: 35 - 163 Aligned: 129 Modelled: 129 Confidence: 99.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of a mutt/nudix family protein from listeria innocua Phyre2 PDB 2fb1 chain A Region: 34 - 165 Aligned: 128 Modelled: 129 Confidence: 99.8% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of protein bt0354 from bacteroides thetaiotaomicron Phyre2 PDB 1nqz chain A Region: 30 - 153 Aligned: 115 Modelled: 124 Confidence: 99.8% Identity: 30% Fold: Nudix Superfamily: Nudix Family: MutT-like Phyre2 PDB 5cfi chain C Region: 34 - 165 Aligned: 123 Modelled: 132 Confidence: 99.8% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:bis(5'-nucleosyl)-tetraphosphatase (diadenosine PDBTitle: structural and functional attributes of malaria parasite ap4a2 hydrolase Phyre2 PDB 3fjy chain B Region: 34 - 175 Aligned: 138 Modelled: 141 Confidence: 99.8% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:probable mutt1 protein; PDBTitle: crystal structure of a probable mutt1 protein from bifidobacterium2 adolescentis Phyre2 PDB 3ef5 chain A Region: 34 - 165 Aligned: 120 Modelled: 132 Confidence: 99.8% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:probable pyrophosphohydrolase; PDBTitle: structure of the rna pyrophosphohydrolase bdrpph in complex with dgtp Phyre2 1 c2gb5B_ 2 c6o3pA_ 3 c3cngC_ 4 c5gg7A_ 5 d1ktga_ 6 c3gz8C_ 7 c3hhjA_ 8 c3fk9B_ 9 c2pq1B_ 10 d1sjya_ 11 c2rrkA_ 12 c3exqA_ 13 d2fb1a2 14 c3q4iA_ 15 c3i9xA_ 16 c2fb1A_ 17 d1nqza_ 18 c5cfiC_ 19 c3fjyB_ 20 c3ef5A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129